MAPKs in the early steps of senescence implemEMTation.
MAPKs
epithelial-mesenchymal transition (EMT)
fibrosis
senescence
senescence-associated secretory phenotype
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
10
2022
accepted:
03
03
2023
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
epublish
Résumé
Evidence is accumulating that the earliest stages of the DNA damage response can direct cells toward senescence instead of other cell fates. In particular, tightly regulated signaling through Mitogen-Activated Protein Kinases (MAPKs) in early senescence can lead to a sustained pro-survival program and suppress a pro-apoptotic program. Importantly, an epithelial-to-mesenchymal Transition (EMT)-like program appears essential for preventing apoptosis and favoring senescence following DNA damage. In this review, we discuss how MAPKs might influence EMT features to promote a senescent phenotype that increases cell survival at the detriment of tissue function.
Identifiants
pubmed: 37009481
doi: 10.3389/fcell.2023.1083401
pii: 1083401
pmc: PMC10060890
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1083401Informations de copyright
Copyright © 2023 Anerillas, Altés and Gorospe.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
EMBO J. 2015 Aug 13;34(16):2162-81
pubmed: 26157010
Cell. 2006 Jun 2;125(5):957-69
pubmed: 16751104
Cell Death Differ. 2019 Jan;26(2):245-259
pubmed: 29786073
Cancer Lett. 2004 Sep 30;213(2):129-38
pubmed: 15327827
Cancer Metastasis Rev. 2009 Jun;28(1-2):15-33
pubmed: 19169796
J Cell Sci. 2005 Feb 1;118(Pt 3):485-96
pubmed: 15657080
Nat Cell Biol. 2015 Aug;17(8):1049-61
pubmed: 26147250
J Dermatol Sci. 2010 Nov;60(2):105-13
pubmed: 20851575
Cell. 2017 Jun 1;169(6):1000-1011
pubmed: 28575665
Cell Signal. 2008 Nov;20(11):2113-8
pubmed: 18760348
J Biol Chem. 2006 Nov 24;281(47):35965-74
pubmed: 17003042
Annu Rev Pathol. 2010;5:99-118
pubmed: 20078217
Cell. 2019 Oct 31;179(4):813-827
pubmed: 31675495
Front Cell Dev Biol. 2020 Dec 21;8:607483
pubmed: 33409282
Genes Dev. 2007 Mar 1;21(5):562-77
pubmed: 17344417
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Cell Rep. 2019 Apr 23;27(4):997-1007.e5
pubmed: 31018144
Oncotarget. 2017 May 29;8(33):55684-55714
pubmed: 28903453
Cells. 2021 Sep 22;10(10):
pubmed: 34685488
Nat Commun. 2022 Oct 20;13(1):6228
pubmed: 36266274
J Invest Dermatol. 2021 Apr;141(4S):1052-1062.e12
pubmed: 32931807
Cell. 2017 Mar 23;169(1):132-147.e16
pubmed: 28340339
Semin Cancer Biol. 2012 Jun;22(3):194-207
pubmed: 22406545
Science. 2021 Oct 29;374(6567):eabb3420
pubmed: 34709885
Oncotarget. 2016 Aug 11;9(2):1656-1672
pubmed: 29416721
J Signal Transduct. 2012;2012:294097
pubmed: 22545213
EMBO J. 2021 Sep 15;40(18):e108647
pubmed: 34459003
Cell Death Dis. 2017 Oct 26;8(10):e3147
pubmed: 29072694
Oncogene. 2021 Jun;40(23):3929-3941
pubmed: 33981002
EMBO J. 2004 Mar 10;23(5):1155-65
pubmed: 14976548
J Signal Transduct. 2012;2012:289243
pubmed: 22363839
EMBO Mol Med. 2014 Dec 30;7(1):102-23
pubmed: 25550395
PLoS One. 2011;6(10):e26514
pubmed: 22028892
Physiol Rev. 2019 Jan 1;99(1):665-706
pubmed: 30475656
Cell Cycle. 2017 Feb 16;16(4):319-334
pubmed: 27892764
J Lipid Res. 2022 Oct;63(10):100276
pubmed: 36089003
Cell Rep. 2020 Jun 9;31(10):107739
pubmed: 32521264
Nat Rev Mol Cell Biol. 2019 Apr;20(4):199-210
pubmed: 30824861
Aging (Albany NY). 2009 Dec 31;1(12):1008-16
pubmed: 20157583
J Transl Med. 2017 Sep 22;15(1):196
pubmed: 28938915
Cell Cycle. 2017 May 19;16(10):909-910
pubmed: 28459356
Nat Rev Mol Cell Biol. 2019 Feb;20(2):69-84
pubmed: 30459476
EMBO J. 2000 Apr 17;19(8):1745-54
pubmed: 10775259
Mech Ageing Dev. 2021 Sep;198:111528
pubmed: 34181964
Nat Med. 2015 Dec;21(12):1424-35
pubmed: 26646499
Burns Trauma. 2022 Apr 08;10:tkac011
pubmed: 35402628
Nat Cell Biol. 2016 Sep;18(9):979-92
pubmed: 27525720
Cell. 2008 May 30;133(5):878-90
pubmed: 18510931
Biochemistry. 2013 Feb 5;52(5):938-48
pubmed: 23298255
Nature. 2014 May 22;509(7501):439-46
pubmed: 24848057
Cancer Cell. 2005 Aug;8(2):111-8
pubmed: 16098464
FEBS J. 2020 Jul;287(13):2636-2646
pubmed: 32145148
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
Oncotarget. 2016 May 24;7(21):31563-71
pubmed: 26883196
Biomolecules. 2020 Dec 12;10(12):
pubmed: 33322749
Environ Toxicol. 2016 Nov;31(11):1407-1414
pubmed: 25873302
Nat Cell Biol. 2011 Mar;13(3):317-23
pubmed: 21336307
Cancer Res. 2013 Feb 15;73(4):1374-85
pubmed: 23393199
Oncogene. 2017 Jan 12;36(2):242-253
pubmed: 27270426
Mol Biol Cell. 2008 Nov;19(11):4738-49
pubmed: 18716062
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12072-7
pubmed: 11593017
Nat Med. 2015 Sep;21(9):975-7
pubmed: 26340117
EMBO J. 2011 Apr 20;30(8):1536-48
pubmed: 21399611
Int J Oncol. 2013 Apr;42(4):1139-50
pubmed: 23403951
J Biol Chem. 2004 Nov 12;279(46):47455-63
pubmed: 15345715
Nat Med. 2022 Aug;28(8):1556-1568
pubmed: 35953721
Aging (Albany NY). 2017 Nov 22;9(11):2411-2435
pubmed: 29176033
Nat Commun. 2018 May 9;9(1):1840
pubmed: 29743479
Cancer Sci. 2017 May;108(5):952-960
pubmed: 28247944
Front Mol Biosci. 2021 Nov 15;8:708779
pubmed: 34869579
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6766-6774
pubmed: 30877242
Oncotarget. 2016 Mar 8;7(10):11002-17
pubmed: 26716904
Cell Signal. 2014 Jul;26(7):1427-36
pubmed: 24613410
Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96
pubmed: 24556840
Oncogene. 2016 Feb 11;35(6):748-60
pubmed: 25961925
Genes Dev. 2020 Apr 1;34(7-8):489-494
pubmed: 32139422
Front Mol Biosci. 2022 Jun 23;9:928399
pubmed: 35813818
Trends Cell Biol. 2017 Nov;27(11):820-832
pubmed: 28822679
PLoS One. 2013 Aug 09;8(8):e69291
pubmed: 23950888
Cancer Res. 2012 Dec 15;72(24):6382-92
pubmed: 23222305
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):
pubmed: 27920038
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8532-7
pubmed: 12826611
PLoS Genet. 2017 Jul 13;13(7):e1006780
pubmed: 28704371
Sci Rep. 2019 Apr 11;9(1):5912
pubmed: 30976015
Sci Rep. 2017 Dec 11;7(1):17313
pubmed: 29229918
Development. 2005 Jul;132(14):3151-61
pubmed: 15983400
Front Cell Dev Biol. 2019 Jul 19;7:135
pubmed: 31380370
Oncogene. 2017 Jul 13;36(28):3943-3956
pubmed: 28288132
Nat Commun. 2017 Feb 23;8:14532
pubmed: 28230051
Sci Rep. 2016 Oct 19;6:35483
pubmed: 27759037
Nat Cell Biol. 2015 Sep;17(9):1205-17
pubmed: 26280535
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
Int J Mol Sci. 2019 May 30;20(11):
pubmed: 31151270
Int J Mol Sci. 2021 Jun 29;22(13):
pubmed: 34209809
Nat Commun. 2018 May 17;9(1):1982
pubmed: 29773794
Cell. 2013 Nov 21;155(5):1119-30
pubmed: 24238961
Sci Rep. 2019 Jun 5;9(1):8295
pubmed: 31165775
Biomolecules. 2021 Jan 29;11(2):
pubmed: 33572742
Sci Adv. 2022 Apr 8;8(14):eabm0756
pubmed: 35394839
Nat Rev Nephrol. 2022 Oct;18(10):611-627
pubmed: 35922662
Science. 2006 Aug 18;313(5789):968-71
pubmed: 16917063
Mol Biol Cell. 2007 May;18(5):1943-52
pubmed: 17344479
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
pubmed: 21372320
Adv Exp Med Biol. 2013;793:1-19
pubmed: 24104470
Cancer Res. 2011 Jun 1;71(11):3980-90
pubmed: 21502402
Semin Immunol. 2018 Dec;40:101275
pubmed: 31088710
Oncogene. 2016 Nov 17;35(46):5977-5988
pubmed: 27292262
Clin Sci (Lond). 2020 Oct 30;134(20):2681-2706
pubmed: 33084883
Cancer Discov. 2016 Jun;6(6):612-29
pubmed: 27099234
FEBS Lett. 2012 Jul 4;586(14):1921-8
pubmed: 22710166
EMBO Rep. 2014 Nov;15(11):1139-53
pubmed: 25312810
Front Mol Biosci. 2021 May 05;8:593310
pubmed: 34026818
Int J Mol Sci. 2019 Jun 13;20(12):
pubmed: 31200510
Dev Cell. 2014 Dec 22;31(6):722-33
pubmed: 25499914
Nat Commun. 2018 Dec 21;9(1):5435
pubmed: 30575733
PLoS One. 2012;7(8):e42513
pubmed: 22880011
Geroscience. 2020 Apr;42(2):397-408
pubmed: 32300964
Cancer Cell. 2007 Oct;12(4):342-54
pubmed: 17936559
Sci Signal. 2011 Nov 01;4(197):ra71
pubmed: 22045851
Oncogene. 2007 Feb 22;26(8):1178-87
pubmed: 16924234
Elife. 2016 May 14;5:
pubmed: 27178982
EMBO J. 2020 Sep 1;39(17):e103209
pubmed: 32692442
EMBO J. 2002 Jul 15;21(14):3749-59
pubmed: 12110587
Cell. 2013 Nov 21;155(5):1104-18
pubmed: 24238962
Nat Cell Biol. 2019 Jan;21(1):94-101
pubmed: 30602768
Cell. 2016 Feb 25;164(5):840-2
pubmed: 26919422
Cell. 2003 May 2;113(3):301-14
pubmed: 12732139
Mol Oncol. 2016 May;10(5):663-76
pubmed: 26781944
Cancer Res. 2019 Aug 15;79(16):4135-4148
pubmed: 31209060
Science. 2020 Jun 19;368(6497):1371-1376
pubmed: 32439659
Mol Cancer Res. 2019 Jan;17(1):153-164
pubmed: 30131448
Cell Rep. 2017 Mar 7;18(10):2480-2493
pubmed: 28273461
Mol Syst Biol. 2010;6:347
pubmed: 20160708
Nat Commun. 2016 Apr 06;7:11190
pubmed: 27048913
Oral Oncol. 2015 Jan;51(1):64-70
pubmed: 25456007
Genes Dev. 2017 Jan 15;31(2):172-183
pubmed: 28143833
Nat Cell Biol. 2013 Aug;15(8):978-90
pubmed: 23770676
Development. 2011 May;138(9):1827-38
pubmed: 21447558
Cell Res. 2009 Jan;19(1):71-88
pubmed: 19002158
Sci Adv. 2020 May 06;6(19):eaay3909
pubmed: 32494696
Aging (Albany NY). 2010 Oct;2(10):735-41
pubmed: 20975209