HPV Integration Can Drive the Formation of Virus-Host Extrachromosomal DNA in Tumors.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
03 04 2023
03 04 2023
Historique:
medline:
4
4
2023
entrez:
3
4
2023
pubmed:
4
4
2023
Statut:
ppublish
Résumé
Human papillomavirus (HPV)-positive cancer cells contain virus and host DNA and exhibit marked genome instability. In this issue of Cancer Discovery, Akagi and colleagues characterize the remarkably complex landscape of virus-host DNA molecules in HPV-positive cells, providing evidence for diverse integrated and extrachromosomal virus-host hybrid DNAs with the potential to drive clonal evolution. See related article by Akagi et al., p. 910 (4).
Identifiants
pubmed: 37009703
pii: 724997
doi: 10.1158/2159-8290.CD-23-0097
doi:
Types de publication
Editorial
Research Support, N.I.H., Extramural
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
814-816Subventions
Organisme : NIAID NIH HHS
ID : R01 AI148431
Pays : United States
Commentaires et corrections
Type : CommentOn
Informations de copyright
©2023 American Association for Cancer Research.