Macrophage Activation Syndrome (MAS): A Case Report and Narrative Review.
adult-onset still’s disease
adult-onset still’s disease (aosd)
hemophagocytic lymphohistiocytosis
hemophagocytic lymphohistiocytosis (hlh)
macrophage activation syndrome
macrophage activation syndrome (mas)
sepsis
uti
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
accepted:
01
03
2023
medline:
5
4
2023
entrez:
4
4
2023
pubmed:
5
4
2023
Statut:
epublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome of excessive inflammation and tissue destruction secondary to abnormal immune activation. The term macrophage activation syndrome (MAS) is used when HLH develops in the setting of systemic juvenile idiopathic arthritis (SJIA; formerly known as Still's disease), adult-onset Still's disease, or any other rheumatologic disorder. We present a case of a 21-year-old female with a known history of SJIA who presented to the hospital with fever, chills, myalgia, nausea, vomiting, and hypotension. Initial evaluation at the time of presentation suggested sepsis likely due to acute pyelonephritis, and the patient was started on antibiotics and intravenous fluid hydration. However, further workup suggested that her symptoms were non-infectious and were likely due to MAS, a rare complication of SJIA. We promptly diagnosed her, and she received a course of steroids and made an uneventful recovery.
Identifiants
pubmed: 37012949
doi: 10.7759/cureus.35670
pmc: PMC10065992
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e35670Informations de copyright
Copyright © 2023, Dilibe et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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