Memory consolidation during sleep involves context reinstatement in humans.
CP: Neuroscience
context
contextual reinstatement
memory consolidation
sleep
targeted memory reactivation
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
31
10
2022
revised:
07
02
2023
accepted:
19
03
2023
medline:
4
10
2023
pubmed:
5
4
2023
entrez:
4
4
2023
Statut:
ppublish
Résumé
New memories are not quarantined from each other when first encoded; rather, they are interlinked with memories that were encoded in temporal proximity or that share semantic features. By selectively biasing memory processing during sleep, here we test whether context influences sleep consolidation. Participants first formed 18 idiosyncratic narratives, each linking four objects together. Before sleep, they also memorized an on-screen position for each object. During sleep, 12 object-specific sounds were unobtrusively presented, thereby cuing the corresponding spatial memories and impacting spatial recall as a function of initial memory strength. As hypothesized, we find that recall for non-cued objects contextually linked with cued objects also changed. Post-cue electrophysiological responses suggest that activity in the sigma band supports context reinstatement and predicts context-related memory benefits. Concurrently, context-specific electrophysiological activity patterns emerge during sleep. We conclude that reactivation of individual memories during sleep evokes reinstatement of their context, thereby impacting consolidation of associated knowledge.
Identifiants
pubmed: 37014750
pii: S2211-1247(23)00342-X
doi: 10.1016/j.celrep.2023.112331
pmc: PMC10545811
mid: NIHMS1895580
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
112331Subventions
Organisme : NIMH NIH HHS
ID : K99 MH122663
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH122663
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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