Intrinsic signalling factors associated with cancer cell-cell fusion.
Cancer cell fusion
Fusogens
Phosphatidylserine (PS)
Post-hybrid selection process (PHSP)
Pre-hybrid preparation program (PHPP)
Pro-fusogenic state
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
04 04 2023
04 04 2023
Historique:
received:
12
01
2023
accepted:
21
02
2023
medline:
6
4
2023
entrez:
4
4
2023
pubmed:
5
4
2023
Statut:
epublish
Résumé
Cellular fusion e.g. between cancer cells and normal cells represents a stepwise process that is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer cells are promoted to a pro-fusogenic state as a prerequisite to prepare a fusion process. A pro-fusogenic state requires significant changes including restructure of the cytoskeleton, e.g., by the formation of F-actin. Moreover, distinct plasma membrane lipids such as phosphatidylserine play an important role during cell fusion. In addition, the expression of distinct fusogenic factors such as syncytins and corresponding receptors are of fundamental importance to enable cellular mergers. Subsequent hybrid formation and fusion are followed by a post-hybrid selection process. Fusion among normal cells is important and often required during organismal development. Cancer cells fusion appears more rarely and is associated with the generation of new cancer hybrid cell populations. These cancer hybrid cells contribute to an elevated tumour plasticity by altered metastatic behaviour, changes in therapeutic and apoptotic responses, and even in the formation of cancer stem/ initiating cells. While many parts within this multi-step cascade are still poorly understood, this review article predominantly focusses on the intracellular necessities for fusion among cancer cells or with other cell populations of the tumour microenvironment. Video Abstract.
Identifiants
pubmed: 37016404
doi: 10.1186/s12964-023-01085-5
pii: 10.1186/s12964-023-01085-5
pmc: PMC10071245
doi:
Substances chimiques
Actins
0
Types de publication
Video-Audio Media
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
68Informations de copyright
© 2023. The Author(s).
Références
Sci Adv. 2018 Sep 12;4(9):eaat7828
pubmed: 30214939
J Cell Biol. 2023 Feb 6;222(2):
pubmed: 36394541
Adv Exp Med Biol. 2011;713:33-64
pubmed: 21432013
Trends Cancer. 2017 Mar;3(3):225-234
pubmed: 28718433
Science. 2017 Apr 21;356(6335):323-327
pubmed: 28386024
Dev Cell. 2018 Sep 24;46(6):767-780.e7
pubmed: 30197239
Placenta. 2005 Aug;26(7):556-62
pubmed: 15993705
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11211-6
pubmed: 22736793
Methods Mol Biol. 2015;1313:1-19
pubmed: 25947653
Int J Mol Sci. 2022 Nov 24;23(23):
pubmed: 36499015
Int J Mol Sci. 2015 Dec 19;16(12):30362-81
pubmed: 26703575
Nat Cell Biol. 2008 May;10(5):575-83
pubmed: 18425116
Bone Marrow Transplant. 2004 Jul;34(2):183-6
pubmed: 15195072
PLoS One. 2012;7(9):e44991
pubmed: 23028727
Int J Mol Sci. 2020 Mar 06;21(5):
pubmed: 32155721
Mol Cell Biol. 2003 May;23(10):3566-74
pubmed: 12724415
Biochim Biophys Acta. 2003 Aug 18;1641(2-3):175-81
pubmed: 12914958
Semin Cancer Biol. 2022 Jun;81:96-105
pubmed: 33713795
Sci Rep. 2021 Jul 1;11(1):13630
pubmed: 34211050
Int J Cancer. 1989 Oct 15;44(4):731-7
pubmed: 2793245
J Clin Invest. 2004 May;113(9):1266-70
pubmed: 15124017
Cell Res. 2008 Jul;18(7):705-7
pubmed: 18521104
PLoS One. 2009 Aug 06;4(8):e6530
pubmed: 19657387
Cancer Lett. 2009 Jul 18;280(1):44-9
pubmed: 19327884
J Mol Biol. 2009 Sep 18;392(2):301-18
pubmed: 19616006
Mol Cancer Res. 2008 Apr;6(4):555-67
pubmed: 18403635
Cell Commun Signal. 2018 Oct 13;16(1):67
pubmed: 30316300
Oncotarget. 2019 Apr 12;10(28):2660-2674
pubmed: 31105868
Clin Cancer Res. 2017 Oct 1;23(19):5892-5911
pubmed: 28679769
Int J Mol Sci. 2019 Feb 18;20(4):
pubmed: 30781614
Stem Cells. 2018 Jul;36(7):977-989
pubmed: 29569804
PLoS One. 2019 Jan 30;14(1):e0206713
pubmed: 30699112
PLoS One. 2013 Jun 26;8(6):e66731
pubmed: 23840523
BJOG. 2006 Feb;113(2):152-8
pubmed: 16411991
Cell Mol Life Sci. 2020 Apr;77(8):1551-1569
pubmed: 31642939
Cancers (Basel). 2020 Jul 29;12(8):
pubmed: 32751163
Nat Med. 2004 Jul;10(7):744-8
pubmed: 15195088
Physiol Rev. 2018 Jan 1;98(1):215-238
pubmed: 29212790
Dev Cell. 2007 Apr;12(4):557-69
pubmed: 17419994
J Mol Med (Berl). 2007 Jan;85(1):23-38
pubmed: 17066266
Int J Dev Biol. 2010;54(2-3):475-82
pubmed: 19876835
Front Immunol. 2021 Jul 23;12:709466
pubmed: 34367171
Development. 2012 Feb;139(4):641-56
pubmed: 22274696
Cancer Med. 2019 Jun;8(6):3047-3058
pubmed: 31025548
N Engl J Med. 1986 Dec 25;315(26):1650-9
pubmed: 3537791
Nat Rev Cancer. 2008 May;8(5):377-86
pubmed: 18385683
FASEB J. 2014 Aug;28(8):3703-19
pubmed: 24812088
Oncol Lett. 2021 Jul;22(1):530
pubmed: 34055095
Biol Open. 2017 Sep 15;6(9):1324-1328
pubmed: 28760733
Int J Mol Sci. 2022 Dec 16;23(24):
pubmed: 36555709
J Biol Chem. 2021 Jan-Jun;296:100411
pubmed: 33581114
Onco Targets Ther. 2018 Dec 17;12:31-40
pubmed: 30588028
BMC Cancer. 2015 Nov 20;15:922
pubmed: 26585897
Oncoimmunology. 2020 Jun 16;9(1):1773204
pubmed: 32923132
Nature. 2005 Mar 10;434(7030):234-8
pubmed: 15759005
Cell Death Discov. 2021 Jul 8;7(1):177
pubmed: 34238921
Curr Biol. 2020 Jul 6;30(13):R750-R754
pubmed: 32634411
Front Oncol. 2021 May 13;11:658489
pubmed: 34055625
Placenta. 2012 Nov;33(11):933-41
pubmed: 22999499
Placenta. 2009 Mar;30 Suppl A:S49-54
pubmed: 19027159
Tumour Biol. 2016 Apr;37(4):5025-30
pubmed: 26537586
Trends Cell Biol. 2009 Oct;19(10):514-22
pubmed: 19733078
Bone Marrow Transplant. 2005 May;35(10):1021-4
pubmed: 15778726
Nat Rev Cancer. 2005 Nov;5(11):899-904
pubmed: 16327766
Cancer Res. 2013 Sep 1;73(17):5360-70
pubmed: 23856249
Sci Adv. 2020 May 06;6(19):eaba0310
pubmed: 32494719
Oncotarget. 2016 Dec 20;7(51):84093-84117
pubmed: 27557521
Cancers (Basel). 2021 Sep 06;13(17):
pubmed: 34503305
Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120507
pubmed: 23938756
Cell. 2002 Nov 15;111(4):589-601
pubmed: 12437931
Int J Gen Med. 2021 Mar 19;14:957-965
pubmed: 33776474
Nat Commun. 2016 Jul 15;7:12198
pubmed: 27416963
Bone. 2011 Apr 1;48(4):837-46
pubmed: 21111077
Front Cell Dev Biol. 2022 Feb 01;9:809668
pubmed: 35178400
JCI Insight. 2021 Dec 22;6(24):
pubmed: 34731091
Nat Cell Biol. 2003 Nov;5(11):959-66
pubmed: 14562057
Cancer Genet. 2021 Aug;256-257:162-164
pubmed: 34166887
AIDS. 2014 Nov 28;28(18):2659-70
pubmed: 25250834
PLoS One. 2015 Aug 12;10(8):e0134320
pubmed: 26267609
Crit Rev Microbiol. 2018 Nov;44(6):715-738
pubmed: 30318978
Annu Rev Cell Dev Biol. 2014;30:111-39
pubmed: 25000995
Cell Mol Life Sci. 2006 Aug;63(16):1906-11
pubmed: 16871371
PLoS Genet. 2009 Feb;5(2):e1000385
pubmed: 19229314
Nat Med. 2003 Dec;9(12):1520-7
pubmed: 14625546
Oncogene. 2014 Jul 24;33(30):3947-58
pubmed: 24013223
Biomed Res. 2022;43(4):107-114
pubmed: 35989286
PLoS One. 2013;8(1):e55572
pubmed: 23383228
Science. 2011 Sep 30;333(6051):1895-8
pubmed: 21960636
J Thorac Oncol. 2020 Sep;15(9):1460-1471
pubmed: 32416323
Nature. 2013 Jul 18;499(7458):301-5
pubmed: 23868259
Development. 2017 Dec 15;144(24):4481-4495
pubmed: 29254991
Mol Cell Biol. 2015 Dec 14;36(4):645-59
pubmed: 26667038
Nature. 2010 Oct 7;467(7316):707-10
pubmed: 20861837
Sci Rep. 2022 Jun 22;12(1):10552
pubmed: 35732788
Cell Commun Signal. 2012 Sep 03;10(1):26
pubmed: 22943670
J Cell Biol. 2019 May 6;218(5):1436-1451
pubmed: 30936162
Clin Exp Metastasis. 1998 May;16(4):299-312
pubmed: 9626809
Cancers (Basel). 2020 Dec 11;12(12):
pubmed: 33322354
Cancer Res. 2011 Feb 15;71(4):1497-505
pubmed: 21303980
J Cell Physiol. 2017 Jun;232(6):1396-1403
pubmed: 27714815
Hum Pathol. 2007 May;38(5):726-31
pubmed: 17306327
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
Lancet. 2001 Feb 17;357(9255):539-45
pubmed: 11229684
Oncol Lett. 2021 Feb;21(2):121
pubmed: 33552242
Nature. 2002 Apr 4;416(6880):542-5
pubmed: 11932747
Cancers (Basel). 2021 Oct 26;13(21):
pubmed: 34771528
J Exp Med. 1995 Nov 1;182(5):1545-56
pubmed: 7595224
Trends Cell Biol. 2017 Dec;27(12):917-930
pubmed: 28899600
Sci Rep. 2016 Nov 09;6:36863
pubmed: 27827439
Biomed Res Int. 2019 Jul 11;2019:5013592
pubmed: 31380426
FASEB J. 2015 Sep;29(9):4036-45
pubmed: 26085132
Int J Cancer. 2016 May 15;138(10):2322-33
pubmed: 26455580
Curr Biol. 2016 Jul 25;26(14):R661-2
pubmed: 27374339
Nat Cell Biol. 2011 Mar;13(3):199-201
pubmed: 21364569
Elife. 2022 Jun 07;11:
pubmed: 35670667
Cell Biol Int. 1994 Mar;18(3):207-10
pubmed: 8019495
Cancers (Basel). 2019 Feb 05;11(2):
pubmed: 30764554
Nat Commun. 2017 Jun 01;8:15665
pubmed: 28569755
Int J Mol Sci. 2021 May 31;22(11):
pubmed: 34072967
Sci Rep. 2013;3:1462
pubmed: 23492904
Mol Cancer Res. 2019 Mar;17(3):806-820
pubmed: 30587522
Nat Commun. 2019 Oct 1;10(1):4456
pubmed: 31575859
J Gen Physiol. 2018 Nov 5;150(11):1498-1509
pubmed: 30257928
Cells. 2021 Jan 15;10(1):
pubmed: 33467484
Trends Cell Biol. 2021 Jan;31(1):62-74
pubmed: 33092941
Cancers (Basel). 2019 Sep 25;11(10):
pubmed: 31557960
Nat Rev Mol Cell Biol. 2008 Jul;9(7):543-56
pubmed: 18496517
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Cell Commun Signal. 2016 Sep 08;14(1):20
pubmed: 27608835
PLoS One. 2012;7(7):e41052
pubmed: 22829910
Semin Cell Dev Biol. 2016 Dec;60:121-126
pubmed: 27476112
Nat Ecol Evol. 2021 Mar;5(3):379-391
pubmed: 33462489
Chin Clin Oncol. 2021 Jan;10(5):45
pubmed: 34670374
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2088-93
pubmed: 12576546
PLoS One. 2017 Feb 1;12(2):e0168581
pubmed: 28146572
Adv Exp Med Biol. 2011;713:97-111
pubmed: 21432016
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12921-6
pubmed: 18728192
Cell Rep. 2019 Jun 25;27(13):3916-3926.e5
pubmed: 31242423
Cancer Biol Ther. 2016 Aug 2;17(8):859-69
pubmed: 27045201
Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6321-5
pubmed: 16606845
Cell Commun Signal. 2018 Jan 5;16(1):2
pubmed: 29329589
Stem Cells. 2018 Jul;36(7):951-968
pubmed: 29603861
Int J Mol Sci. 2020 Mar 09;21(5):
pubmed: 32182935
Int J Mol Sci. 2016 Jun 02;17(6):
pubmed: 27271591
Int J Mol Sci. 2020 Nov 06;21(21):
pubmed: 33172211
Cancer Cell. 2003 May;3(5):445-8
pubmed: 12781362
Int J Mol Sci. 2020 Dec 17;21(24):
pubmed: 33348862
Nature. 2003 Apr 24;422(6934):901-4
pubmed: 12665833
PLoS One. 2011 May 05;6(5):e19569
pubmed: 21573181
Nature. 2013 May 9;497(7448):263-7
pubmed: 23615608
Trends Cell Biol. 2019 Dec;29(12):964-973
pubmed: 31648852
Anim Cells Syst (Seoul). 2022 Jan 12;25(6):358-368
pubmed: 35059135
J Gen Virol. 2006 Jul;87(Pt 7):2067-2071
pubmed: 16760410
Nat Commun. 2016 Feb 15;7:10754
pubmed: 26876972
Cancers (Basel). 2021 Sep 16;13(18):
pubmed: 34572863
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9385-90
pubmed: 19458257
Cell. 2006 Nov 17;127(4):679-95
pubmed: 17110329
Trends Genet. 2013 Jul;29(7):427-37
pubmed: 23453622
Sci Rep. 2017 Jan 23;7:40983
pubmed: 28112190
Nature. 2003 Apr 24;422(6934):897-901
pubmed: 12665832
Oncotarget. 2016 Sep 20;7(38):60793-60806
pubmed: 27563823
J Virol. 2000 Apr;74(7):3321-9
pubmed: 10708449
PLoS Pathog. 2017 Jun 26;13(6):e1006451
pubmed: 28651004
Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C385-95
pubmed: 24336652
Retrovirology. 2017 Mar 17;14(1):20
pubmed: 28302141