Long-Term Exposure to Air Pollution and COVID-19 Vaccine Antibody Response in a General Population Cohort (COVICAT Study, Catalonia).
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
medline:
7
4
2023
entrez:
5
4
2023
pubmed:
6
4
2023
Statut:
ppublish
Résumé
Ambient air pollution has been associated with COVID-19 disease severity and antibody response induced by infection. We examined the association between long-term exposure to air pollution and vaccine-induced antibody response. This study was nested in an ongoing population-based cohort, COVICAT, the GCAT-Genomes for Life cohort, in Catalonia, Spain, with multiple follow-ups. We drew blood samples in 2021 from 1,090 participants of 2,404 who provided samples in 2020, and we included 927 participants in this analysis. We measured immunoglobulin M (IgM), IgG, and IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), and segment spike-protein (S2) triggered by vaccines available in Spain. We estimated prepandemic (2018-2019) exposure to fine particulate matter [PM Among vaccinated persons not infected by SARS-CoV-2 ( Exposure to air pollution was associated with lower COVID-19 vaccine antibody response. The implications of this association on the risk of breakthrough infections require further investigation. https://doi.org/10.1289/EHP11989.
Sections du résumé
BACKGROUND
Ambient air pollution has been associated with COVID-19 disease severity and antibody response induced by infection.
OBJECTIVES
We examined the association between long-term exposure to air pollution and vaccine-induced antibody response.
METHODS
This study was nested in an ongoing population-based cohort, COVICAT, the GCAT-Genomes for Life cohort, in Catalonia, Spain, with multiple follow-ups. We drew blood samples in 2021 from 1,090 participants of 2,404 who provided samples in 2020, and we included 927 participants in this analysis. We measured immunoglobulin M (IgM), IgG, and IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), and segment spike-protein (S2) triggered by vaccines available in Spain. We estimated prepandemic (2018-2019) exposure to fine particulate matter [PM
RESULTS
Among vaccinated persons not infected by SARS-CoV-2 (
DISCUSSION
Exposure to air pollution was associated with lower COVID-19 vaccine antibody response. The implications of this association on the risk of breakthrough infections require further investigation. https://doi.org/10.1289/EHP11989.
Identifiants
pubmed: 37017430
doi: 10.1289/EHP11989
pmc: PMC10075082
doi:
Substances chimiques
Air Pollutants
0
COVID-19 Vaccines
0
Particulate Matter
0
Nitrogen Dioxide
S7G510RUBH
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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