Interplay between endogenous and exogenous human retroviruses.
HERV expression
endogenous retroviruses
human T-lymphotropic virus
human immunodeficiency virus
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
17
01
2023
revised:
09
03
2023
accepted:
13
03
2023
medline:
17
8
2023
pubmed:
6
4
2023
entrez:
5
4
2023
Statut:
ppublish
Résumé
In humans, retroviruses thrive more as symbionts than as parasites. Apart from the only two modern exogenous human retroviruses (human T-cell lymphotropic and immunodeficiency viruses; HTLV and HIV, respectively), ~8% of the human genome is occupied by ancient retroviral DNA [human endogenous retroviruses (HERVs)]. Here, we review the recent discoveries about the interactions between the two groups, the impact of infection by exogenous retroviruses on the expression of HERVs, the effect of HERVs on the pathogenicity of HIV and HTLV and on the severity of the diseases caused by them, and the antiviral protection that HERVs can allegedly provide to the host. Tracing the crosstalk between contemporary retroviruses and their endogenized ancestors will provide better understanding of the retroviral world.
Identifiants
pubmed: 37019721
pii: S0966-842X(23)00088-4
doi: 10.1016/j.tim.2023.03.008
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
933-946Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors have no interests to declare.