Applications of artificial intelligence-machine learning for detection of stress: a critical overview.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
05 Apr 2023
Historique:
received: 12 10 2021
accepted: 20 03 2023
revised: 17 03 2023
entrez: 5 4 2023
pubmed: 6 4 2023
medline: 6 4 2023
Statut: aheadofprint

Résumé

Psychological distress is a major contributor to human physiology and pathophysiology, and it has been linked to several conditions, such as auto-immune diseases, metabolic syndrome, sleep disorders, and suicidal thoughts and inclination. Therefore, early detection and management of chronic stress is crucial for the prevention of several diseases. Artificial intelligence (AI) and Machine Learning (ML) have promoted a paradigm shift in several areas of biomedicine including diagnosis, monitoring, and prognosis of disease. Here, our review aims to present some of the AI and ML applications for solving biomedical issues related to psychological stress. We provide several lines of evidence from previous studies highlighting that AI and ML have been able to predict stress and detect the brain normal states vs. abnormal states (notably, in post-traumatic stress disorder (PTSD)) with accuracy around 90%. Of note, AI/ML-driven technology applied to identify ubiquitously present stress exposure may not reach its full potential, unless future analytics focus on detecting prolonged distress through such technology instead of merely assessing stress exposure. Moving forward, we propose that a new subcategory of AI methods called Swarm Intelligence (SI) can be used towards detecting stress and PTSD. SI involves ensemble learning techniques to efficiently solve a complex problem, such as stress detection, and it offers particular strength in clinical settings, such as privacy preservation. We posit that AI and ML approaches will be beneficial for the medical and patient community when applied to predict and assess stress levels. Last, we encourage additional research to bring AI and ML into the standard clinical practice for diagnostics in the not-too-distant future.

Identifiants

pubmed: 37020048
doi: 10.1038/s41380-023-02047-6
pii: 10.1038/s41380-023-02047-6
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

Références

Gupta R, Alam MA, Agarwal P. Modified support vector machine for detecting stress level using EEG signals. Comput Intell Neurosci. 2020;2020:8860841.
pubmed: 32802030 pmcid: 7416233 doi: 10.1155/2020/8860841
Tan SY, Yip A. Hans Selye (1907–1982): founder of the stress theory. Singap Med J. 2018;59:170.
doi: 10.11622/smedj.2018043
Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267:1244–52.
pubmed: 1538563 doi: 10.1001/jama.1992.03480090092034
Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5:374–81.
pubmed: 19488073 doi: 10.1038/nrendo.2009.106
Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialog Clin Neurosci. 2006;8:383.
doi: 10.31887/DCNS.2006.8.4/ssmith
Mastorakos G, Magiakou MA, Chrousos GP. Effects of the immune/inflammatory reaction on the hypothalamic-pituitary-adrenal axis. Ann NY Acad Sci. 1995;771:438–48.
pubmed: 8597420 doi: 10.1111/j.1749-6632.1995.tb44700.x
Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 1998;128:127–37.
pubmed: 9441573 doi: 10.7326/0003-4819-128-2-199801150-00009
Vgontzas AN, Bixler EO, Lin HM, Prolo P, Trakada G, Chrousos GP. IL-6 and its circadian secretion in humans. Neuroimmunomodulation. 2005;12:131–40.
pubmed: 15905620 doi: 10.1159/000084844
Koumantarou Malisiova E, Mourikis I, Darviri C, Nicolaides NC, Zervas IM, Papageorgiou C, et al. Hair cortisol concentrations in mental disorders: A systematic review. Physiol Behav. 2021;229:113244.
pubmed: 33181165 doi: 10.1016/j.physbeh.2020.113244
Bougea A, Anagnostouli M, Angelopoulou E, Spanou I, Chrousos G. Psychosocial and Trauma-Related Stress and Risk of Dementia: A Meta-Analytic Systematic Review of Longitudinal Studies. J Geriatr Psychiatry Neurol. 2022;35:24–37.
Hatzimanolis A, Avramopoulos D, Arking DE, Moes A, Bhatnagar P, Lencz T, et al. Stress-dependent association between polygenic risk for schizophrenia and schizotypal traits in young army recruits. Schizophr Bull. 2018;44:338–47.
pubmed: 29036523 doi: 10.1093/schbul/sbx074
Mentis AA, Dardiotis E, Efthymiou V, Chrousos GP. Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews. BMC Med. 2021;19:6.
pubmed: 33435977 pmcid: 7805241 doi: 10.1186/s12916-020-01873-7
Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016;19:1442–53.
pubmed: 27668389 pmcid: 5083142 doi: 10.1038/nn.4399
Hatzimanolis A, Bhatnagar P, Moes A, Wang R, Roussos P, Bitsios P, et al. Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood. Am J Med Genet B Neuropsychiatr Genet. 2015;168b:392–401.
pubmed: 25963331 doi: 10.1002/ajmg.b.32323
Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506:185–90.
pubmed: 24463508 pmcid: 4136494 doi: 10.1038/nature12975
Roussos P, Giakoumaki SG, Zouraraki C, Fullard JF, Karagiorga VE, Tsapakis EM, et al. The relationship of common risk variants and polygenic risk for schizophrenia to sensorimotor gating. Biol Psychiatry. 2016;79:988–96.
pubmed: 26212897 doi: 10.1016/j.biopsych.2015.06.019
Roussos P, Bitsios P, Giakoumaki SG, McClure MM, Hazlett EA, New AS, et al. CACNA1C as a risk factor for schizotypal personality disorder and schizotypy in healthy individuals. Psychiatry Res. 2013;206:122–3.
pubmed: 22985546 doi: 10.1016/j.psychres.2012.08.039
Roussos P, Giakoumaki SG, Adamaki E, Georgakopoulos A, Robakis NK, Bitsios P. The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males. Neuropsychopharmacology. 2011;36:1677–88.
pubmed: 21471957 pmcid: 3138651 doi: 10.1038/npp.2011.49
Chan K, Lee T-W, Sample PA, Goldbaum MH, Weinreb RN, Sejnowski TJ. Comparison of machine learning and traditional classifiers in glaucoma diagnosis. IEEE Trans Biomed Eng. 2002;49:963–74.
pubmed: 12214886 doi: 10.1109/TBME.2002.802012
Colwell LJ. Statistical and machine learning approaches to predicting protein–ligand interactions. Curr Opin Struct Biol. 2018;49:123–8.
pubmed: 29452923 doi: 10.1016/j.sbi.2018.01.006
Makridakis S, Spiliotis E, Assimakopoulos V. Statistical and Machine Learning forecasting methods: Concerns and ways forward. PloS one. 2018;13:e0194889.
pubmed: 29584784 pmcid: 5870978 doi: 10.1371/journal.pone.0194889
Chatterjee P, Cymberknop LJ, Armentano RL. Nonlinear systems in healthcare towards intelligent disease prediction. Nonlinear systems—theoretical aspects and recent applications. IntechOpen 2019.
Chrousos GP, Kino T. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Science’s STKE. 2005;2005:pe48.
pubmed: 16204701
Flesia L, Monaro M, Mazza C, Fietta V, Colicino E, Segatto B, et al. Predicting perceived stress related to the Covid-19 outbreak through stable psychological traits and machine learning models. J Clin Med. 2020;9:3350.
pubmed: 33086558 pmcid: 7603217 doi: 10.3390/jcm9103350
OMURCA, Sevinç İlhan; EKINCI, Ekin. An alternative evaluation of post traumatic stress disorder with machine learning methods. In: Proceedings of the 2015 International Symposium on Innovations in Intelligent SysTems and Applications (INISTA). IEEE, Madrid, Spain, 2015. p. 1–7
Alberdi A, Aztiria A, Basarab A. Towards an automatic early stress recognition system for office environments based on multimodal measurements: a review. J Biomed Inform. 2016;59:49–75.
pubmed: 26621099 doi: 10.1016/j.jbi.2015.11.007
Barua S, Begum S, Ahmed MU. Supervised machine learning algorithms to diagnose stress for vehicle drivers based on physiological sensor signals. In: Proceedings of the pHealth. IOS Press BV, Amsterdam, Netherlands, 2015. p. 241–8.
Siegel CE, Laska EM, Lin Z, Xu M, Abu-Amara D, Jeffers MK, et al. Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates. Transl Psychiatry. 2021;11:1–12.
doi: 10.1038/s41398-021-01324-8
Galatzer-Levy IR, Ma S, Statnikov A, Yehuda R, Shalev AY. Utilization of machine learning for prediction of post-traumatic stress: a re-examination of cortisol in the prediction and pathways to non-remitting PTSD. Transl Psychiatry. 2017;7:e1070–e1070.
pmcid: 5416681 doi: 10.1038/tp.2017.38
Agorastos A, Chrousos GP. The neuroendocrinology of stress: the stress-related continuum of chronic disease development. Mol Psychiatry. 2022;27:502–13.
pubmed: 34290370 doi: 10.1038/s41380-021-01224-9
Love BC. Comparing supervised and unsupervised category learning. Psychonom Bull Rev. 2002;9:829–35.
doi: 10.3758/BF03196342
Camacho DM, Collins KM, Powers RK, Costello JC, Collins JJ. Next-generation machine learning for biological networks. Cell. 2018;173:1581–92.
pubmed: 29887378 doi: 10.1016/j.cell.2018.05.015
Goecks J, Jalili V, Heiser LM, Gray JW. How machine learning will transform biomedicine. Cell. 2020;181:92–101.
pubmed: 32243801 pmcid: 7141410 doi: 10.1016/j.cell.2020.03.022
Rajkomar A, Dean J, Kohane I. Machine learning in medicine. N Engl J Med. 2019;380:1347–58.
pubmed: 30943338 doi: 10.1056/NEJMra1814259
Schwalbe N, Wahl B. Artificial intelligence and the future of global health. Lancet. 2020;395:1579–86.
pubmed: 32416782 pmcid: 7255280 doi: 10.1016/S0140-6736(20)30226-9
Vollmer S, Mateen BA, Bohner G, Király FJ, Ghani R, Jonsson P. et al. Machine learning and artificial intelligence research for patient benefit: 20 critical questions on transparency, replicability, ethics, and effectiveness. BMJ. 2020;368:6927
doi: 10.1136/bmj.l6927
Peterson ED. Machine learning, predictive analytics, and clinical practice: can the past inform the present? JAMA. 2019;322:2283–4.
pubmed: 31755902 doi: 10.1001/jama.2019.17831
Meskó B, Görög M. A short guide for medical professionals in the era of artificial intelligence. npj Digit Med. 2020;3:1–8.
doi: 10.1038/s41746-020-00333-z
Harrison JH, Gilbertson JR, Hanna MG, Olson NH, Seheult JN, Sorace JM, et al. Introduction to artificial intelligence and machine learning for pathology. Arch Pathol Lab Med. 2021;145:1228–54.
Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25:44–56.
pubmed: 30617339 doi: 10.1038/s41591-018-0300-7
Bates DW, Auerbach A, Schulam P, Wright A, Saria S. Reporting and implementing interventions involving machine learning and artificial intelligence. Ann Intern Med. 2020;172:S137–S144.
pubmed: 32479180 doi: 10.7326/M19-0872
Hinton G. Deep learning—a technology with the potential to transform health care. Jama. 2018;320:1101–2.
pubmed: 30178065 doi: 10.1001/jama.2018.11100
Mentis AA, Garcia I, Jiménez J, Paparoupa M, Xirogianni A, Papandreou A, et al. Artificial intelligence in differential diagnostics of meningitis: a nationwide study. Diagnostics. 2021;11:602.
pubmed: 33800653 pmcid: 8065596 doi: 10.3390/diagnostics11040602
Richards BA, Lillicrap TP, Beaudoin P, Bengio Y, Bogacz R, Christensen A, et al. A deep learning framework for neuroscience. Nat Neurosci. 2019;22:1761–70.
pubmed: 31659335 pmcid: 7115933 doi: 10.1038/s41593-019-0520-2
Sawalha J, Cao L, Chen J, Selvitella A, Liu Y, Yang C, et al. Individualized identification of first-episode bipolar disorder using machine learning and cognitive tests. J Affect Disord. 2021;282:662–8.
pubmed: 33445089 doi: 10.1016/j.jad.2020.12.046
Le-Niculescu H, Roseberry K, Levey D, Rogers J, Kosary K, Prabha S, et al. Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs. Mol Psychiatry. 2020;25:918–38.
pubmed: 30862937 doi: 10.1038/s41380-019-0370-z
Oquendo M, Baca-Garcia E, Artes-Rodriguez A, Perez-Cruz F, Galfalvy H, Blasco-Fontecilla H, et al. Machine learning and data mining: strategies for hypothesis generation. Mol Psychiatry. 2012;17:956–9.
pubmed: 22230882 doi: 10.1038/mp.2011.173
Passos IC, Mwangi B. Machine learning-guided intervention trials to predict treatment response at an individual patient level: an important second step following randomized clinical trials. Mol Psychiatry. 2020;25:701–2.
pubmed: 30242230 doi: 10.1038/s41380-018-0250-y
Durstewitz D, Koppe G, Meyer-Lindenberg A. Deep neural networks in psychiatry. Mol Psychiatry. 2019;24:1583–98.
pubmed: 30770893 doi: 10.1038/s41380-019-0365-9
Hedderich DM, Eickhoff SB. Machine learning for psychiatry: getting doctors at the black box? Mol Psychiatry. 2021;26:23–25.
pubmed: 33173196 doi: 10.1038/s41380-020-00931-z
Bracher-Smith M, Crawford K, Escott-Price V. Machine learning for genetic prediction of psychiatric disorders: a systematic review. Mol Psychiatry. 2021;26:70–9.
pubmed: 32591634 doi: 10.1038/s41380-020-0825-2
Kelly CJ, Karthikesalingam A, Suleyman M, Corrado G, King D. Key challenges for delivering clinical impact with artificial intelligence. BMC Med. 2019;17:1–9.
doi: 10.1186/s12916-019-1426-2
Comparison of heart rate variability measures for mental stress detection. In: Proceedings of the computing in cardiology. 2011. IEEE.
Mental stress detection using heart rate variability and morphologic variability of EeG signals. In: Proceedings of the international conference and exposition on electrical and power engineering 2012. IEEE.
Remote assessment of the heart rate variability to detect mental stress. In: Proceedings of the 7th International Conference on Pervasive Computing Technologies for Healthcare and Workshops, 2013. IEEE.
Healey JA, Picard RW. Detecting stress during real-world driving tasks using physiological sensors. IEEE Trans Intell Transport Syst. 2005;6:156–66.
doi: 10.1109/TITS.2005.848368
Picard RW, Vyzas E, Healey J. Toward machine emotional intelligence: analysis of affective physiological state. IEEE Trans Pattern Anal Mach Intell. 2001;23:1175–91.
doi: 10.1109/34.954607
Taylor S, Jaques N, Nosakhare E, Sano A, Picard R. Personalized multitask learning for predicting tomorrow’s mood, stress, and health. IEEE Trans Affect Comput. 2017;11:200–13.
pubmed: 32489521 pmcid: 7266106 doi: 10.1109/TAFFC.2017.2784832
Ye C, Kumar BV, Coimbra MT. An automatic subject-adaptable heartbeat classifier based on multiview learning. IEEE J Biomed Health Inf. 2016;20:1485–92.
doi: 10.1109/JBHI.2015.2468224
Huang S-C, Pareek A, Zamanian R, Banerjee I, Lungren MP. Multimodal fusion with deep neural networks for leveraging CT imaging and electronic health record: a case-study in pulmonary embolism detection. Sci Rep. 2020;10:1–9.
doi: 10.1038/s41598-020-78888-w
Zheng Y, Wong TC, Leung BH, Poon CC. Unobtrusive and multimodal wearable sensing to quantify anxiety. IEEE Sens J. 2016;16:3689–96.
doi: 10.1109/JSEN.2016.2539383
Classification tree for real-life stress detection using linear Heart Rate Variability analysis. Case study: students under stress due to university examination. In: Proceedings of the World Congress on Medical Physics and Biomedical Engineering May 26–31, 2012, Beijing, China 2013. Springer.
Akella A, Singh AK, Leong D, Lal S, Newton P, Clifton-Bligh R, et al. Classifying multi-level stress responses from brain cortical EEG in nurses and non-health professionals using machine learning auto encoder. IEEE J Transl Eng Health Med. 2021;9:2200109.
pubmed: 34094720 doi: 10.1109/JTEHM.2021.3077760
Li B, Sano A. Extraction and interpretation of deep autoencoder-based temporal features from wearables for forecasting personalized mood, health, and stress. Proc ACM Interact, Mob, Wearable Ubiquitous Technol. 2020;4:1–26.
El Haouij N, Poggi J-M, Ghozi R, Sevestre-Ghalila S, Jaïdane M. Random forest-based approach for physiological functional variable selection for driver’s stress level classification. Stat Methods Appl. 2019;28:157–85.
doi: 10.1007/s10260-018-0423-5
Tsamardinos I, Charonyktakis P, Papoutsoglou G, Borboudakis G, Lakiotaki K, Zenklusen JC, et al. Just Add Data: automated predictive modeling for knowledge discovery and feature selection. NPJ Precis Oncol. 2022;6:1–17.
Candel A, Parmar V, LeDell E, Arora A. Deep learning with H2O. H2O AI Inc 2016 p. 1–21.
Can YS, Chalabianloo N, Ekiz D, Ersoy C. Continuous stress detection using wearable sensors in real life: algorithmic programming contest case study. Sensors. 2019;19:1849.
pubmed: 31003456 pmcid: 6515276 doi: 10.3390/s19081849
Jordan A. On discriminative vs. generative classifiers: a comparison of logistic regression and naive Bayes. Adv Neural Inform Process Syst. 2002;14:841.
Remote measurement of cognitive stress via heart rate variability. In: Proceedings of the 36th annual international conference of the IEEE Engineering in Medicine and Biology Society. 2014. IEEE.
Noble WS. What is a support vector machine? Nat Biotechnol. 2006;24:1565–7.
pubmed: 17160063 doi: 10.1038/nbt1206-1565
Scholkopf B, Sung K-K, Burges CJ, Girosi F, Niyogi P, Poggio T, et al. Comparing support vector machines with Gaussian kernels to radial basis function classifiers. IEEE Trans Signal Process. 1997;45:2758–65.
doi: 10.1109/78.650102
Stress detection in computer users based on digital signal processing of noninvasive physiological variables. In: Proceedings of the international conference of the IEEE engineering in medicine and biology society 2006. IEEE.
Support vector machine for classification of stress subjects using EEG signals. In: Proceedings of the IEEE Conference on Systems, Process and Control (ICSPC 2014) 2014. IEEE.
Attallah O. An effective mental stress state detection and evaluation system using minimum number of frontal brain electrodes. Diagnostics. 2020;10:292.
pubmed: 32397517 pmcid: 7278014 doi: 10.3390/diagnostics10050292
Subhani AR, Mumtaz W, Saad MNBM, Kamel N, Malik AS. Machine learning framework for the detection of mental stress at multiple levels. IEEE Access. 2017;5:13545–56.
doi: 10.1109/ACCESS.2017.2723622
Ho TK. The random subspace method for constructing decision forests. IEEE Trans Pattern Anal Mach Intell. 1998;20:832–44.
doi: 10.1109/34.709601
Lykken D, Rose R, Luther B, Maley M. Correcting psychophysiological measures for individual differences in range. Psychol Bull. 1966;66:481.
pubmed: 5974620 doi: 10.1037/h0023922
Brodersen KH, Gallusser F, Koehler J, Remy N, Scott SL. Inferring causal impact using Bayesian structural time-series models. Ann Appl Stat. 2015;9:247–74.
doi: 10.1214/14-AOAS788
Scott SL, Varian HR. Predicting the present with Bayesian structural time series. Int J Math Model Numer Optim. 2014;5:4–23.
Liu J, Spakowicz DJ, Ash GI, Hoyd R, Ahluwalia R, Zhang A, et al. Bayesian structural time series for biomedical sensor data: a flexible modeling framework for evaluating interventions. PLoS Comput Biol. 2021;17:e1009303.
pubmed: 34424894 pmcid: 8412351 doi: 10.1371/journal.pcbi.1009303
Wang S-C. Artificial neural network. Interdisciplinary computing in java programming. Springer 2003, p. 81–100.
Liu W, Wang Z, Liu X, Zeng N, Liu Y, Alsaadi FE. A survey of deep neural network architectures and their applications. Neurocomputing. 2017;234:11–26.
doi: 10.1016/j.neucom.2016.12.038
Bolea J, Pueyo E, Orini M, Bailón R. Influence of heart rate in non-linear HRV indices as a sampling rate effect evaluated on supine and standing. Front Physiol. 2016;7:501.
pubmed: 27895588 pmcid: 5108795 doi: 10.3389/fphys.2016.00501
PsychologiCal Stress Detection Using Deep Convolutional Neural Networks. In: Proceedings of the International Conference on Computer Vision and Image Processing 2019. Springer.
Cho Y, Julier SJ, Bianchi-Berthouze N. Instant stress: detection of perceived mental stress through smartphone photoplethysmography and thermal imaging. JMIR Ment Health. 2019;6:e10140.
pubmed: 30964440 pmcid: 6477570 doi: 10.2196/10140
Can YS, Arnrich B, Ersoy C. Stress detection in daily life scenarios using smart phones and wearable sensors: a survey. J Biomed Inform. 2019;92:103139.
pubmed: 30825538 doi: 10.1016/j.jbi.2019.103139
Towards mental stress detection using wearable physiological sensors. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011. IEEE.
Doan S, Yang EW, Tilak SS, Li PW, Zisook DS, Torii M. Extracting health-related causality from Twitter messages using natural language processing. BMC Med Inform Decis Mak. 2019;19:79.
pubmed: 30943954 pmcid: 6448183 doi: 10.1186/s12911-019-0785-0
Chekroud AM, Bondar J, Delgadillo J, Doherty G, Wasil A, Fokkema M, et al. The promise of machine learning in predicting treatment outcomes in psychiatry. World Psychiatry. 2021;20:154–70.
pubmed: 34002503 pmcid: 8129866 doi: 10.1002/wps.20882
Zaremba W, Sutskever I, Vinyals O. Recurrent neural network regularization. arXiv preprint arXiv:14092329 2014.
Chipman HA, George EI, McCulloch RE. BART: Bayesian additive regression trees. Ann Appl Stat. 2010;4:266–98.
doi: 10.1214/09-AOAS285
Jamil Z. Monitoring tweets for depression to detect at-risk users. Université d’Ottawa/University of Ottawa 2017.
He Q, Veldkamp BP, Glas CA, de Vries T. Automated assessment of patients’ self-narratives for posttraumatic stress disorder screening using natural language processing and text mining. Assessment. 2017;24:157–72.
pubmed: 26358713 doi: 10.1177/1073191115602551
Cho H-M, Park H, Dong S-Y, Youn I. Ambulatory and laboratory stress detection based on raw electrocardiogram signals using a convolutional neural network. Sensors. 2019;19:4408.
pubmed: 31614646 pmcid: 6833036 doi: 10.3390/s19204408
Rodriguez-Paras C, Tippey K, Brown E, Sasangohar F, Creech S, Kum H-C, et al. Posttraumatic stress disorder and mobile health: app investigation and scoping literature review. JMIR mHealth uHealth. 2017;5:e156.
pubmed: 29074470 pmcid: 5680516 doi: 10.2196/mhealth.7318
Wshah S, Skalka C, Price M. Predicting posttraumatic stress disorder risk: a machine learning approach. JMIR Ment Health. 2019;6:e13946.
pubmed: 31333201 pmcid: 6681635 doi: 10.2196/13946
Gini C. Concentration and dependency ratios. Riv Polit Econom. 1997;87:769–92.
Saxe GN, Ma S, Ren J, Aliferis C. Machine learning methods to predict child posttraumatic stress: a proof of concept study. BMC Psychiatry. 2017;17:1–13.
doi: 10.1186/s12888-017-1384-1
Karstoft K-I, Galatzer-Levy IR, Statnikov A, Li Z, Shalev AY. Bridging a translational gap: using machine learning to improve the prediction of PTSD. BMC Psychiatry. 2015;15:1–7.
doi: 10.1186/s12888-015-0399-8
Galatzer-Levy IR, Karstoft K-I, Statnikov A, Shalev AY. Quantitative forecasting of PTSD from early trauma responses: a machine learning application. J Psychiatr Res. 2014;59:68–76.
pubmed: 25260752 pmcid: 4252741 doi: 10.1016/j.jpsychires.2014.08.017
Galatzer-Levy IR, Bonanno GA. Optimism and death: Predicting the course and consequences of depression trajectories in response to heart attack. Psychol Sci. 2014;25:2177–88.
pubmed: 25298294 doi: 10.1177/0956797614551750
Galatzer-Levy IR, Bonanno GA, Bush DE, LeDoux J. Heterogeneity in threat extinction learning: Substantive and methodological considerations for identifying individual difference in response to stress. Front Behav Neurosci. 2013;7:55.
pubmed: 23754992 pmcid: 3665921 doi: 10.3389/fnbeh.2013.00055
Galatzer-Levy IR, Bryant RA. 636,120 ways to have posttraumatic stress disorder. Perspect Psychol Sci. 2013;8:651–62.
pubmed: 26173229 doi: 10.1177/1745691613504115
Galatzer-Levy IR, Ruggles KV, Chen Z. Data science in the Research Domain Criteria era: relevance of machine learning to the study of stress pathology, recovery, and resilience. Chronic Stress. 2018;2:2470547017747553.
pubmed: 29527592 pmcid: 5841258 doi: 10.1177/2470547017747553
Galatzer-Levy IR, Steenkamp MM, Brown AD, Qian M, Inslicht S, Henn-Haase C, et al. Cortisol response to an experimental stress paradigm prospectively predicts long-term distress and resilience trajectories in response to active police service. J Psychiatr Res. 2014;56:36–42.
pubmed: 24952936 pmcid: 5759781 doi: 10.1016/j.jpsychires.2014.04.020
Karstoft K-I, Statnikov A, Andersen SB, Madsen T, Galatzer-Levy IR. Early identification of posttraumatic stress following military deployment: application of machine learning methods to a prospective study of Danish soldiers. J Affect Disord. 2015;184:170–5.
pubmed: 26093830 doi: 10.1016/j.jad.2015.05.057
Schultebraucks K, Qian M, Abu-Amara D, Dean K, Laska E, Siegel C, et al. Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors. Mol Psychiatry. 2020;26:1–12.
McDonald AD, Sasangohar F, Jatav A, Rao AH. Continuous monitoring and detection of post-traumatic stress disorder (PTSD) triggers among veterans: a supervised machine learning approach. IISE Trans Healthc Syst Eng. 2019;9:201–11.
doi: 10.1080/24725579.2019.1583703
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc: Ser B (Methodol). 1995;57:289–300.
Geronikolou S, Drosatos G, Chrousos G. Emotional analysis of twitter posts during the first phase of the COVID-19 pandemic in Greece: infoveillance study. JMIR Form Res. 2021;5:e27741.
pubmed: 34469328 pmcid: 8483272 doi: 10.2196/27741
Abd Rahman R, Omar K, Noah SAM, Danuri MSNM, Al-Garadi MA. Application of machine learning methods in mental health detection: a systematic review. IEEE Access. 2020;8:183952–64.
doi: 10.1109/ACCESS.2020.3029154
Pries L-K, van Os J, Ten Have M, de Graaf R, van Dorsselaer S, Bak M, et al. Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia. JAMA Psychiatry. 2020;77:1296–304.
pubmed: 32805017 doi: 10.1001/jamapsychiatry.2020.2304
Galatzer-Levy IR, Huang SH, Bonanno GA. Trajectories of resilience and dysfunction following potential trauma: a review and statistical evaluation. Clin Psychol Rev. 2018;63:41–55.
pubmed: 29902711 doi: 10.1016/j.cpr.2018.05.008
Norris FH, Tracy M, Galea S. Looking for resilience: understanding the longitudinal trajectories of responses to stress. Soc Sci Med. 2009;68:2190–8.
pubmed: 19403217 doi: 10.1016/j.socscimed.2009.03.043
Schultebraucks K, Shalev AY, Michopoulos V, Grudzen CR, Shin SM, Stevens JS, et al. A validated predictive algorithm of post-traumatic stress course following emergency department admission after a traumatic stressor. Nat Med. 2020;26:1084–8.
pubmed: 32632194 doi: 10.1038/s41591-020-0951-z
Schultebraucks K, Sijbrandij M, Galatzer-Levy I, Mouthaan J, Olff M, van Zuiden M. Forecasting individual risk for long-term Posttraumatic Stress Disorder in emergency medical settings using biomedical data: a machine learning multicenter cohort study. Neurobiol Stress. 2021;14:100297.
pubmed: 33553513 pmcid: 7843920 doi: 10.1016/j.ynstr.2021.100297
Schultebraucks K, Ben-Zion Z, Admon R, Keynan JN, Liberzon I, Hendler T, et al. Assessment of early neurocognitive functioning increases the accuracy of predicting chronic PTSD risk. Mol Psychiatry. 2022;27:2247–54.
pubmed: 35082440 doi: 10.1038/s41380-022-01445-6
Straus LD, An X, Ji Y, McLean SA, Neylan TC, Cakmak AS, et al. Utility of wrist-wearable data for assessing pain, sleep, and anxiety outcomes after traumatic stress exposure. JAMA Psychiatry. 2023.
Beaudoin FL, An X, Basu A, Ji Y, Liu M, Kessler RC, et al. Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort. Transl Psychiatry. 2023;13:4.
pubmed: 36609484 pmcid: 9823011 doi: 10.1038/s41398-022-02289-y
Swarm intelligence in cellular robotic systems. In: Proceedings of the Robots and biological systems: towards a new bionics? 1993. Springer.
Grosan C, Abraham A, Chis M. Swarm intelligence in data mining. Springer 2006.
Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, et al. Swarm Learning as a privacy-preserving machine learning approach for disease classification. BioRxiv. 2020. 2020.06. 25.171009.
Particle swarm optimization. In: Proceedings of the Proceedings of ICNN'95-international conference on neural networks 1995. IEEE.
Bonabeau E, Corne D, Poli R. Swarm intelligence: the state of the art special issue of natural computing. Nat Comput. 2010;9:655–7.
doi: 10.1007/s11047-009-9172-6
An ensemble PSO-based approach for diagnosis of coronary artery disease. In: Proceedings of the International Symposium on Artificial Intelligence and Signal Processing (AISP). 2011. IEEE.
Best MG, Sol N, GJG S, Vancura A, Muller M, Niemeijer A-LN, et al. Swarm intelligence-enhanced detection of non-small-cell lung cancer using tumor-educated platelets. Cancer Cell. 2017;32:238–52.e239.
pubmed: 28810146 pmcid: 6381325 doi: 10.1016/j.ccell.2017.07.004
Chuang L-Y, Lin Y-D, Chang H-W, Yang C-H. An improved PSO algorithm for generating protective SNP barcodes in breast cancer. PLoS One. 2012;7:e37018.
pubmed: 22623973 pmcid: 3356401 doi: 10.1371/journal.pone.0037018
Ludermir TB, De Oliveira WR. Particle swarm optimization of MLP for the identification of factors related to common mental disorders. Expert Syst Appl. 2013;40:4648–52.
doi: 10.1016/j.eswa.2013.02.003
Feature selection for bi-objective stress classification using emerging swarm intelligence metaheuristic techniques. In: Proceedings of the Proceedings of Data Analytics and Management: ICDAM. 2021, Volume 2, 2022. Springer.
Sharma S, Singh G, Sharma M. A comprehensive review and analysis of supervised-learning and soft computing techniques for stress diagnosis in humans. Comput Biol Med. 2021;134:104450.
pubmed: 33989896 doi: 10.1016/j.compbiomed.2021.104450
de Santos Sierra A, Ávila CS, Casanova JG, del Pozo GB. A stress-detection system based on physiological signals and fuzzy logic. IEEE Trans Ind Electron. 2011;58:4857–65.
doi: 10.1109/TIE.2010.2103538
Stress detection from audio on multiple window analysis size in a public speaking task. In: Proceedings of the Humaine Association Conference on Affective Computing and Intelligent Interaction. 2013. IEEE.
Vanitha V, Krishnan P. Real-time stress detection system based on EEG signals. 2016.
Mozos OM, Sandulescu V, Andrews S, Ellis D, Bellotto N, Dobrescu R, et al. Stress detection using wearable physiological and sociometric sensors. Int J Neural Syst. 2017;27:1650041.
pubmed: 27440466 doi: 10.1142/S0129065716500416
Understanding physiological responses to stressors during physical activity. In: Proceedings of the ACM conference on ubiquitous computing. 2012.
Akmandor AO, Jha NK. Keep the stress away with SoDA: Stress detection and alleviation system. IEEE Trans Multi-Scale Comput Syst. 2017;3:269–82.
doi: 10.1109/TMSCS.2017.2703613
Asif A, Majid M, Anwar SM. Human stress classification using EEG signals in response to music tracks. Comput Biol Med. 2019;107:182–96.
pubmed: 30836290 doi: 10.1016/j.compbiomed.2019.02.015
Jin C, Jia H, Lanka P, Rangaprakash D, Li L, Liu T, et al. Dynamic brain connectivity is a better predictor of PTSD than static connectivity. Hum Brain Mapp. 2017;38:4479–96.
pubmed: 28603919 pmcid: 6866943 doi: 10.1002/hbm.23676
Kessler RC, Rose S, Koenen KC, Karam EG, Stang PE, Stein DJ, et al. How well can post‐traumatic stress disorder be predicted from pre‐trauma risk factors? An exploratory study in the WHO World Mental Health Surveys. World Psychiatry. 2014;13:265–74.
pubmed: 25273300 pmcid: 4219068 doi: 10.1002/wps.20150
Liu F, Xie B, Wang Y, Guo W, Fouche J-P, Long Z, et al. Characterization of post-traumatic stress disorder using resting-state fMRI with a multi-level parametric classification approach. Brain Topogr. 2015;28:221–37.
pubmed: 25078561 doi: 10.1007/s10548-014-0386-2
Reece AG, Danforth CM. Instagram photos reveal predictive markers of depression. EPJ Data Sci. 2017;6:1–12.
Rosellini AJ, Dussaillant F, Zubizarreta JR, Kessler RC, Rose S. Predicting posttraumatic stress disorder following a natural disaster. J Psychiatr Res. 2018;96:15–22.
pubmed: 28950110 doi: 10.1016/j.jpsychires.2017.09.010
Tahmasian M, Jamalabadi H, Abedini M, Ghadami MR, Sepehry AA, Knight DC, et al. Differentiation chronic post traumatic stress disorder patients from healthy subjects using objective and subjective sleep-related parameters. Neurosci Lett. 2017;650:174–9.
pubmed: 28450190 doi: 10.1016/j.neulet.2017.04.042
Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, et al. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: a pilot study. Psychoneuroendocrinology. 2015;51:472–94.
pubmed: 25311155 doi: 10.1016/j.psyneuen.2014.09.024
The relationship between Precision-Recall and ROC curves. In: Proceedings of the 23rd international conference on Machine learning. 2006.
Area under the precision-recall curve: point estimates and confidence intervals. In: Proceedings of the Joint European conference on machine learning and knowledge discovery in databases. 2013. Springer.
A study of cross-validation and bootstrap for accuracy estimation and model selection. In: Proceedings of the Ijcai. 1995. Montreal, Canada.

Auteurs

Alexios-Fotios A Mentis (AA)

University Research Institute of Maternal and Child Health & Precision Medicine, Athens, Greece. amentis1@jhu.edu.
UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece. amentis1@jhu.edu.

Donghoon Lee (D)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Panos Roussos (P)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mental Illness Research, Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA.

Classifications MeSH