The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia.
cardiovascular complications
children
high systolic blood pressure
hyperdynamic left ventricle
left ventricular dilatation
mitral valve insufficiency
pulmonary hypertension
saudi arabia
sickle cell disease
tricuspid valve insufficiency
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
accepted:
27
02
2023
medline:
7
4
2023
entrez:
6
4
2023
pubmed:
7
4
2023
Statut:
epublish
Résumé
Background Sickle cell disease (SCD) is a common hematological disorder with a high prevalence in Saudi Arabia. Despite that, limited studies are available in our region regarding cardiovascular complications. Objectives The objective of the current study was to estimate the prevalence of cardiovascular complications among children with SCD. Design This was a cross-sectional study. Setting The study took place at a single tertiary-care center in Jeddah, Saudi Arabia. Materials and methods The study reviewed 126 electronic records of pediatric patients up to 16 years old diagnosed with SCD between January 2008 and December 2019 in King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. Of these, 54 patients had a previous echocardiogram evaluation and were eligible for the study. Main outcomes measures The study identified cardiovascular complications in pediatric sickle cell patients. Sample size The study included a total of 54 pediatric sickle cell patients. Results The mean age was 11.9 (3.48) years, the male-to-female ratio was 2:1, the majority (94.4%) had the HbSS-HbSβ0 genotype, the mean baseline hemoglobin F (fetal hemoglobin) was 20.30 (9.03%), and the clinical severity score was severe in 19 (35.2%) and mild/moderate in 35 (64.8%) patients. Cardiovascular complications occurred in 32 (59.3%) patients. Increased systolic blood pressure was detected in 10 (18.5%) patients. Echocardiography showed left ventricular dilatation in nine (16.7%) patients, tricuspid valve insufficiency in six (11.1%) patients, mitral valve insufficiency in four (7.4%) patients, hyperdynamic left ventricle in one (1.9%) patient, and pulmonary hypertension in one (1.9%) patient. Long QTc interval was noticed in three (5.6%) and cardiomegaly was detected in 18 (33.3%) patients. Conclusion Cardiovascular complications occurred at a high frequency in our pediatric population despite high baseline hemoglobin F levels. Early evaluation and continuous monitoring are important for early intervention.
Identifiants
pubmed: 37020484
doi: 10.7759/cureus.35751
pmc: PMC10069165
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e35751Informations de copyright
Copyright © 2023, Waggass et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Hematol. 2010 Oct;85(10):746-51
pubmed: 20806231
Blood. 2009 Nov 19;114(21):4639-44
pubmed: 19724057
Pediatr Cardiol. 2019 Dec;40(8):1670-1678
pubmed: 31542803
Echocardiography. 2013 May;30(5):521-6
pubmed: 23305504
Pediatrics. 2017 Sep;140(3):
pubmed: 28827377
Eur J Haematol. 2013 Aug;91(2):170-8
pubmed: 23621844
N Engl J Med. 2017 Feb 2;376(5):429-439
pubmed: 27959701
J Am Coll Cardiol. 2012 Mar 27;59(13):1123-33
pubmed: 22440212
Br J Haematol. 2014 Feb;164(4):597-604
pubmed: 24224700
Card Electrophysiol Rev. 2002 Sep;6(3):289-94
pubmed: 12114854
Ann Saudi Med. 2011 May-Jun;31(3):289-93
pubmed: 21623060
Ann Trop Paediatr. 2000 Sep;20(3):243-6
pubmed: 11064781
Am J Hematol. 2008 Jan;83(1):19-25
pubmed: 17724699
Sudan J Paediatr. 2012;12(1):70-8
pubmed: 27493331
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):423-430
pubmed: 29222288
Pediatr Cardiol. 2008 Mar;29(2):309-12
pubmed: 17680298
Pediatr Blood Cancer. 2009 Jul;52(7):842-6
pubmed: 19229972
Haematologica. 2013 Mar;98(3):464-72
pubmed: 22983573
Eur Heart J. 2020 Apr 1;41(13):1365-1373
pubmed: 31005979
Am J Hematol. 2007 Jun;82(6):433-8
pubmed: 17266053