Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome.

Alzheimer's disease Down syndrome basal forebrain biomarkers cholinergic magnetic resonance imaging neuroimaging volumetry

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
11 2023
Historique:
revised: 30 12 2022
received: 03 10 2022
accepted: 04 01 2023
medline: 16 11 2023
pubmed: 7 4 2023
entrez: 6 4 2023
Statut: ppublish

Résumé

Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume. In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance. BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.

Sections du résumé

BACKGROUND
Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS.
METHODS
We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume.
RESULTS
In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance.
DISCUSSION
BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.

Identifiants

pubmed: 37021589
doi: 10.1002/alz.12999
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4817-4827

Subventions

Organisme : NIA NIH HHS
ID : R01 AG056480
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG056850
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG056974
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG013566
Pays : United States

Informations de copyright

© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Mateus Rozalem Aranha (M)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Maria Florencia Iulita (MF)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Victor Montal (V)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Jordi Pegueroles (J)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Alexandre Bejanin (A)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Lídia Vaqué-Alcázar (L)

Institute of Neurosciences, Universitat de Barcelona, Barcelona, Spain.
Department of Medicine, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Michel J Grothe (MJ)

Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

Maria Carmona-Iragui (M)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.

Laura Videla (L)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.

Bessy Benejam (B)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.

Javier Arranz (J)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.

Concepción Padilla (C)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Sílvia Valldeneu (S)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Isabel Barroeta (I)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Miren Altuna (M)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Susana Fernández (S)

Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.

Laia Ribas (L)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Natalia Valle-Tamayo (N)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Daniel Alcolea (D)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Sofía González-Ortiz (S)

Hospital del Mar - Parc de Salut Mar, Barcelona, Spain.
Neuroradiology Section, Radiology Department, Diagnostic Image Center, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.

Núria Bargalló (N)

Neuroradiology Section, Radiology Department, Diagnostic Image Center, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
Magnetic Resonance Image Core Facility (IDIBAPS), Barcelona, Spain.

Henrik Zetterberg (H)

Queen Square Institute of Neurology, University College London, London, UK.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
UK Dementia Research Institute, University College London, London, UK.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Hong Kong Center for Neurodegenerative Diseases, China, Hong Kong.

Kaj Blennow (K)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Rafael Blesa (R)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Thomas Wisniewski (T)

Departments of Neurology, Pathology and Psychiatry and Center for Cognitive Neurology, New York University Grossman School of Medicine, New York, New York, USA.

Jorge Busciglio (J)

Department of Neurobiology & Behavior, Institute for Memory Impairments and Neurological Disorders (iMIND), Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, California, USA.

A Claudio Cuello (AC)

Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Department of Pharmacology, Oxford University, Oxford, UK.

Alberto Lleó (A)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Juan Fortea (J)

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.
Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.

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