Multi-omic and spatial dissection of immunotherapy response groups in non-small cell lung cancer.
immunotherapy
lung cancer
multi-omic
multiplex
spatial transcriptomics
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
07
09
2022
accepted:
27
03
2023
medline:
18
7
2023
pubmed:
7
4
2023
entrez:
6
4
2023
Statut:
ppublish
Résumé
The composition and activation status of the cellular milieu contained within the tumour microenvironment (TME) is becoming increasingly recognized as a driving factor for immunotherapy response. Here, we employed multiplex immunohistochemistry (mIHC), and digital spatial profiling (DSP) to capture the targeted immune proteome and transcriptome of tumour and TME compartments from an immune checkpoint inhibitor (ICI)-treated (n = 41) non-small cell lung cancer (NSCLC) patient cohort. We demonstrate by mIHC that the interaction of CD68
Substances chimiques
Interleukin-2
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
487-502Informations de copyright
© 2023 The Authors. Immunology published by John Wiley & Sons Ltd.
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