Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases.

Humans Methylation Alternative Splicing RNA Editing Neurodegenerative Diseases / genetics RNA / genetics RNA, Messenger / metabolism Brain / metabolism Aging / genetics
A-to-I RNA editing Alternative Splicing Brain aging M6A RNA Methylation Neurodegenerative diseases

Journal

Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227

Informations de publication

Date de publication:
06 2023
Historique:
received: 14 02 2023
revised: 31 03 2023
accepted: 03 04 2023
medline: 9 6 2023
pubmed: 7 4 2023
entrez: 6 4 2023
Statut: ppublish

Résumé

Aging is a physiological and progressive phenomenon in all organisms' life cycle, characterized by the accumulation of degenerative processes triggered by several alterations within molecular pathways. These changes compromise cell fate, resulting in the loss of functions in tissues throughout the body, including the brain. Physiological brain aging has been linked to structural and functional alterations, as well as to an increased risk of neurodegenerative diseases. Post-transcriptional RNA modifications modulate mRNA coding properties, stability, translatability, expanding the coding capacity of the genome, and are involved in all cellular processes. Among mRNA post-transcriptional modifications, the A-to-I RNA editing, m6A RNA Methylation and Alternative Splicing play a critical role in all the phases of a neuronal cell life cycle and alterations in their mechanisms of action significantly contribute to aging and neurodegeneration. Here we review our current understanding of the contribution of A-to-I RNA editing, m6A RNA Methylation, and Alternative Splicing to physiological brain aging process and neurodegenerative diseases.

Identifiants

DOI: 10.1016/j.mad.2023.111807 PMID: 37023929
pubmed: 37023929
pii: S0047-6374(23)00033-7
doi: 10.1016/j.mad.2023.111807
pii:
doi:

Substances chimiques

RNA 63231-63-0
RNA, Messenger 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111807

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interests All the authors declare no conflict of interests.

Auteurs

Valentina Tassinari (V)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: valentina.tassinari@uniroma2.it.

Piergiorgio La Rosa (P)

Division of Neuroscience, Department of Psychology, Sapienza University of Rome, Rome, Italy; European Center for Brain Research, IRCCS Fondazione Santa Lucia, Rome, Italy.

Eugenia Guida (E)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Ambra Colopi (A)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Sara Caratelli (S)

Department of Biomedicine, Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy.

Francesca De Paolis (F)

Department of Biomedicine, Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy.

Angela Gallo (A)

RNA Editing Lab., Oncohaematology Department, Cellular and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Carlo Cenciarelli (C)

Department of Biomedicine, Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy.

Giuseppe Sconocchia (G)

Department of Biomedicine, Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy.

Susanna Dolci (S)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Valeriana Cesarini (V)

Department of Biomedicine, Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy. Electronic address: valeriana.cesarini@ift.cnr.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Édition des ARN › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Contribution of A-to-I RNA editing, M6A RNA...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Contribution of A-to-I RNA editing, M6A RNA...