Severe malaria in children and adolescents in Southeast Gabon.
Children
Malaria prevalence
Severe forms
Severe malaria
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
06 Apr 2023
06 Apr 2023
Historique:
received:
15
10
2022
accepted:
02
03
2023
medline:
10
4
2023
entrez:
6
4
2023
pubmed:
7
4
2023
Statut:
epublish
Résumé
Malaria remains a significant public health problem in sub-Saharan Africa. Child mortality due to severe malaria remains high in developing countries despite improvements in malaria management and a better understanding of its pathophysiology. To address the lack of epidemiological studies on severe malaria in Gabon, this study describes the epidemiological aspects of severe malaria in rural, semi-rural, and urban areas of southeast Gabon. Demographic, clinical, and laboratory data for children and adolescents aged 0-18 years were collected in 2019 from hospital records at three health facilities in southeastern Gabon. The patients included in the study were positive for P falciparum malaria diagnosed by microscopy with at least one of the malaria severity criteria. Severe malaria accounted for 18.8% (667/3552) of malaria cases. Children aged 0-5 years accounted for 71.8% (479/667) of all severe malaria cases. Adolescents over 15 years of age were the least affected by severe malaria with 4.2% (28/667). Across the study, severe anemia (49.0%, 327/667), convulsions (43.0%, 287/667), respiratory distress (5.1%, 34/667), and altered consciousness (4.8%, 32/667) were the most frequent clinical signs of severe malaria in children. Franceville was the locality most affected by severe malaria with 49.2% (328/667), followed by Koulamoutou with 42.0% (280/667) and Lastourville with 8.8% (59/667). Convulsions (50.6%, 166/328) and coma (6.1%, 20/328) were more frequent in children living in urban areas. In contrast, severe anemia (56.7%, 186/339) and jaundice (6.8%, 23/339) were more common in children living in semi-rural areas. Severe malaria is more prevalent in urban areas in regions with a high malaria transmission intensity. However, in this study, the epidemiological characteristics of severe malaria were similar in the three settings (urban, rural, and semi-rural areas) despite different levels of urbanization. Nevertheless, the various signs of severity were more frequent in Franceville, an urban area. Children under 5 years of age remain the most vulnerable age group.
Identifiants
pubmed: 37024834
doi: 10.1186/s12879-023-08133-y
pii: 10.1186/s12879-023-08133-y
pmc: PMC10080735
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
207Informations de copyright
© 2023. The Author(s).
Références
PLoS Med. 2010 Aug 17;7(8):e1000328
pubmed: 20808957
Ann Trop Med Parasitol. 1997 Oct;91(7):763-9
pubmed: 9625932
J Infect Public Health. 2020 Oct;13(10):1469-1472
pubmed: 32360023
Am J Trop Med Hyg. 2010 Nov;83(5):981-9
pubmed: 21036824
Malays J Med Sci. 2012 Apr;19(2):5-18
pubmed: 22973133
Am J Trop Med Hyg. 2007 Dec;77(6):1015-9
pubmed: 18165514
Malar Res Treat. 2016;2016:1240962
pubmed: 27047701
Biomed Res Int. 2014;2014:351281
pubmed: 24982865
Malar J. 2013 Jan 02;12:3
pubmed: 23282198
Infect Drug Resist. 2018 Aug 28;11:1329-1338
pubmed: 30214253
Am J Trop Med Hyg. 2007 Jun;76(6):997-1008
pubmed: 17556601
Malar J. 2009 Dec 17;8:300
pubmed: 20017905
BMC Public Health. 2022 Dec 10;22(1):2313
pubmed: 36496354
BMC Public Health. 2015 Feb 04;15:81
pubmed: 25649228
Malar J. 2009 Jul 20;8:166
pubmed: 19619296
J Trop Pediatr. 2015 Aug;61(4):272-8
pubmed: 25957436
Parasitol Res. 2001 Jul;87(7):530-3
pubmed: 11484848
Malar J. 2016 Aug 18;15(1):420
pubmed: 27538948
Sante. 2011 Oct-Dec;21(4):193-8
pubmed: 22362010
Malar J. 2013 May 21;12:167
pubmed: 23692957
Trans R Soc Trop Med Hyg. 2000 Apr;94 Suppl 1:S1-90
pubmed: 11103309
PLoS Med. 2020 Oct 19;17(10):e1003359
pubmed: 33075101
Bull Soc Pathol Exot Filiales. 1987;80(3 Pt 2):532-42
pubmed: 3690800
Am J Trop Med Hyg. 1998 Oct;59(4):539-42
pubmed: 9790426
Malar J. 2005 Jan 09;4:1
pubmed: 15638948
Rev Bras Ter Intensiva. 2011 Sep;23(3):358-69
pubmed: 23949409
Malar J. 2022 Sep 21;21(1):270
pubmed: 36131306
PLoS One. 2017 May 3;12(5):e0176613
pubmed: 28467452
Parasite. 2016;23:32
pubmed: 27492564