Single thalamic localization of brain toxoplasmosis mimicking brain tumors: Radiological and clinical findings.
Brain magnetic resonance imaging
Brain tumor
Cerebral toxoplasmosis
Stereotactic biopsy
Journal
Surgical neurology international
ISSN: 2229-5097
Titre abrégé: Surg Neurol Int
Pays: United States
ID NLM: 101535836
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
01
2023
accepted:
15
02
2023
medline:
8
4
2023
entrez:
7
4
2023
pubmed:
8
4
2023
Statut:
epublish
Résumé
Cerebral toxoplasmosis is a relatively rare disorder that usually affects immunocompromised patients. The most common scenario occurs among human immunodeficiency virus (HIV)-positive patients. In those patients, toxoplasmosis is the most frequent cause of expansive brain lesion and continues to cause elevated morbidity and mortality. In typical cases of toxoplasmosis, both computed tomography and magnetic resonance imaging reveal single/ multiple nodular or ring-enhancing lesions with surrounding edema. Nevertheless, cases of cerebral toxoplasmosis with atypical radiological features have been reported. Diagnosis can be obtained by finding organisms in the cerebrospinal fluid or in stereotactic biopsy samples of the brain lesion. If untreated, cerebral toxoplasmosis is uniformly fatal, so prompt diagnosis is mandatory. A prompt diagnosis is necessary, as untreated cerebral toxoplasmosis is uniformly fatal. We discuss imaging and clinical findings of a patient - not aware of being HIV-positive - with a solitary atypical brain localization of toxoplasmosis mimicking a brain tumor. Although relatively uncommon, neurosurgeons should be aware of the potential occurrence of cerebral toxoplasmosis. High index of suspicion is needed for timely diagnosis and prompt initiation of therapy.
Sections du résumé
Background
UNASSIGNED
Cerebral toxoplasmosis is a relatively rare disorder that usually affects immunocompromised patients. The most common scenario occurs among human immunodeficiency virus (HIV)-positive patients. In those patients, toxoplasmosis is the most frequent cause of expansive brain lesion and continues to cause elevated morbidity and mortality. In typical cases of toxoplasmosis, both computed tomography and magnetic resonance imaging reveal single/ multiple nodular or ring-enhancing lesions with surrounding edema. Nevertheless, cases of cerebral toxoplasmosis with atypical radiological features have been reported. Diagnosis can be obtained by finding organisms in the cerebrospinal fluid or in stereotactic biopsy samples of the brain lesion. If untreated, cerebral toxoplasmosis is uniformly fatal, so prompt diagnosis is mandatory. A prompt diagnosis is necessary, as untreated cerebral toxoplasmosis is uniformly fatal.
Case Description
UNASSIGNED
We discuss imaging and clinical findings of a patient - not aware of being HIV-positive - with a solitary atypical brain localization of toxoplasmosis mimicking a brain tumor.
Conclusion
UNASSIGNED
Although relatively uncommon, neurosurgeons should be aware of the potential occurrence of cerebral toxoplasmosis. High index of suspicion is needed for timely diagnosis and prompt initiation of therapy.
Identifiants
pubmed: 37025531
doi: 10.25259/SNI_34_2023
pii: 10.25259/SNI_34_2023
pmc: PMC10070335
doi:
Types de publication
Case Reports
Langues
eng
Pagination
82Informations de copyright
Copyright: © 2023 Surgical Neurology International.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
World Neurosurg. 2022 Aug;164:330-340
pubmed: 35667553
CNS Drugs. 2003;17(12):869-87
pubmed: 12962527
World Neurosurg. 2022 Dec;168:155-164
pubmed: 36206965
J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219867315
pubmed: 31429353
Semin Neurol. 2008 Sep;28(4):511-22
pubmed: 18843578
World Neurosurg. 2019 Feb;122:e427-e435
pubmed: 30342263
Case Rep Neurol Med. 2018 Feb 21;2018:9876514
pubmed: 29682373
Radiographics. 2008 Nov-Dec;28(7):2033-58
pubmed: 19001657
J Neurol Surg A Cent Eur Neurosurg. 2021 Jul;82(4):344-356
pubmed: 33352612