Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report.
azacytidine
bcl-2
blastic
bpdcn
cd123
dendritic
neoplasm
plasmacytoid
rare
venetoclax
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
accepted:
01
04
2023
medline:
8
4
2023
entrez:
7
4
2023
pubmed:
8
4
2023
Statut:
epublish
Résumé
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon hematological tumor originating from the precursor of plasmacytoid dendritic cells (pDCs) with a persistent and progressive course of illness. Despite being an aggressive disease BPDCN has an initial indolent course manifested as skin lesions. Alongside or following the skin lesion, the extra-cutaneous manifestation develops and includes lymphadenopathy, splenomegaly, and hepatomegaly. The BPDCN diagnosis is mainly based on the immunophenotype. Herein, we report the case of a 72-year-old male patient who presented with a history of left anterior chest wall painless skin lesions. Histology of skin biopsy of the left chest skin lesion showed diffuse dermal infiltration by monomorphic medium-sized blastic cells positive for cluster of differentiation (CD)4, CD45, CD7, CD56, CD43, CD123, T-cell leukemia-1 (TCL1), and B-cell leukemia/lymphoma 2 protein (BCL2). Given the rarity of the disease, standard chemotherapy regimens used in treating different leukemias and lymphomas have been adapted to treat BPDCN.
Identifiants
pubmed: 37026111
doi: 10.7759/cureus.37016
pmc: PMC10072177
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e37016Informations de copyright
Copyright © 2023, Nasiri et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Clin Pathol. 2005 May;123(5):662-75
pubmed: 15981806
Br J Dermatol. 2003 Oct;149(4):869-76
pubmed: 14616384
Expert Opin Investig Drugs. 2018 Sep;27(9):733-739
pubmed: 30118336
Am J Surg Pathol. 2014 May;38(5):673-80
pubmed: 24441662
Hematol Oncol Clin North Am. 2020 Jun;34(3):575-587
pubmed: 32336421
Clin Lymphoma Myeloma Leuk. 2021 Nov;21(11):734-740
pubmed: 34226167
Eur J Haematol. 2014 Jul;93(1):81-5
pubmed: 24571716
J Am Acad Dermatol. 2008 Mar;58(3):480-4
pubmed: 18280345
Leuk Res. 2010 Apr;34(4):438-46
pubmed: 19793612
Cancer. 2002 May 1;94(9):2401-8
pubmed: 12015765
Am J Clin Pathol. 2007 Sep;128(3):445-53
pubmed: 17709319
Leuk Res. 2012 Jan;36(1):81-6
pubmed: 21890199
Br J Haematol. 2016 Jul;174(2):188-202
pubmed: 27264021
Clin Lymphoma Myeloma Leuk. 2019 Sep;19(9):545-554
pubmed: 31281107
Blood. 2002 Mar 1;99(5):1556-63
pubmed: 11861268
Biol Blood Marrow Transplant. 2013 Jul;19(7):1006-12
pubmed: 23396213
Cancers (Basel). 2019 Apr 28;11(5):
pubmed: 31035408
Haematologica. 2013 Feb;98(2):239-46
pubmed: 23065521
Am J Hematol. 1994 Dec;47(4):278-82
pubmed: 7526680
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Blood Adv. 2019 Dec 23;3(24):4238-4251
pubmed: 31869411
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):16-23
pubmed: 27913457
Blood. 2002 Jun 1;99(11):4154-9
pubmed: 12010820