T-large granular lymphocytic leukemia.
Diagnosis
T-cell large granular lymphocyte leukemia
Treatment
Journal
Blood research
ISSN: 2287-979X
Titre abrégé: Blood Res
Pays: Korea (South)
ID NLM: 101605247
Informations de publication
Date de publication:
30 Apr 2023
30 Apr 2023
Historique:
received:
14
02
2023
revised:
11
03
2023
accepted:
14
03
2023
medline:
8
4
2023
pubmed:
8
4
2023
entrez:
7
4
2023
Statut:
ppublish
Résumé
T-cell large granular lymphocyte (T-LGL) leukemia is characterized by clonal expansion of cytotoxic T cells resulting in cytopenia. The proliferation of clonal LGLs is caused by prolonged antigenic stimulation, which leads to apoptotic dysregulation owing mainly to the constitutive activation of survival pathways, notably the JAK/STAT pathway. Understanding how leukemic T-LGL persists can aid in the development of future immunosuppressive therapies. In this review, we summarize the diagnosis and current standard of therapy for T-LGL leukemia, as well as recent advances in clinical trials.
Identifiants
pubmed: 37026382
pii: br.2023.2023037
doi: 10.5045/br.2023.2023037
pmc: PMC10133854
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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