Astrocytic Chitinase-3-like protein 1 in neurological diseases: Potential roles and future perspectives.
astrocyte
chitinase-3-like protein 1
glioma
ischemic stroke
neurodegeneration
traumatic brain injury
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
17
08
2022
received:
09
12
2021
accepted:
29
03
2023
medline:
26
6
2023
pubmed:
8
4
2023
entrez:
7
4
2023
Statut:
ppublish
Résumé
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mainly by reactive astrocytes in the central nervous system. Thus, targeting astrocytic CHI3L1 could be a promising approach for the treatment of neurological diseases, such as traumatic brain injury, ischemic stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and glioma. Based on current knowledge of CHI3L1, we assume that it acts as a molecule mediating several signaling pathways driving the initiation and progression of neurological disorders. This narrative review is the first to introduce the potential roles of astrocytic CHI3L1 in neurological disorders. We also equally explore astrocytic CHI3L1 mRNA expression under physiological and pathological conditions. Inhibiting CHI3L1 and disrupting its interaction with its receptors through multiple mechanisms of action are briefly discussed. These endeavors highlight the pivotal roles of astrocytic CHI3L1 in neurological disorders and could contribute to the development of effective inhibitors based on the strategy of structure-based drug discovery, which could be an attractive therapeutic approach for neurological disease treatment.
Substances chimiques
Chitinase-3-Like Protein 1
0
Chitinases
EC 3.2.1.14
Synapsins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
772-790Subventions
Organisme : Project of Shaanxi Provincial Administration of Traditional Chinese Medicine
ID : 2021-ZZ-JC030
Organisme : National Natural Science Foundation of China
ID : 82204425
Organisme : National Natural Science Foundation of China
ID : 32241007
Informations de copyright
© 2023 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
Références
Adrangi, S., & Faramarzi, M. A. (2013). From bacteria to human: A journey into the world of chitinases. Biotechnology Advances, 31(8), 1786-1795. https://doi.org/10.1016/j.biotechadv.2013.09.012
Almad, A., & Maragakis, N. J. (2018). A stocked toolbox for understanding the role of astrocytes in disease. Nature Reviews Neurology, 14(6), 351-362. https://doi.org/10.1038/s41582-018-0010-2
Andres-Benito, P., Dominguez, R., Colomina, M. J., Llorens, F., Povedano, M., & Ferrer, I. (2018). YKL40 in sporadic amyotrophic lateral sclerosis: Cerebrospinal fluid levels as a prognosis marker of disease progression. Aging, 10(9), 2367-2382. https://doi.org/10.18632/aging.101551
Ansari, K. I., Bhan, A., Liu, X., Chen, M. Y., & Jandial, R. (2020). Astrocytic IGFBP2 and CHI3L1 in cerebrospinal fluid drive cortical metastasis of HER2+breast cancer. Clinical & Experimental Metastasis, 37(3), 401-412. https://doi.org/10.1007/s10585-020-10032-4
Baldacci, F., Lista, S., Cavedo, E., Bonuccelli, U., & Hampel, H. (2017). Diagnostic function of the neuroinflammatory biomarker YKL-40 in Alzheimer's disease and other neurodegenerative diseases. Expert Review of Proteomics, 14(4), 285-299. https://doi.org/10.1080/14789450.2017.1304217
Baldacci, F., Lista, S., Palermo, G., Giorgi, F. S., Vergallo, A., & Hampel, H. (2019). The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: Advances in development. Expert Review of Proteomics, 16(7), 593-600. https://doi.org/10.1080/14789450.2019.1628643
Bjornbak, C., Brochner, C. B., Larsen, L. A., Johansen, J. S., & Mollgard, K. (2014). Brain barriers and a subpopulation of astroglial progenitors of developing human forebrain are immunostained for the glycoprotein YKL-40. The Journal of Histochemistry and Cytochemistry, 62(5), 369-388. https://doi.org/10.1369/0022155414528514
Bonneh-Barkay, D., Bissel, S. J., Kofler, J., Starkey, A., Wang, G., & Wiley, C. A. (2012). Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation. Brain Pathology, 22(4), 530-546. https://doi.org/10.1111/j.1750-3639.2011.00550.x
Bonneh-Barkay, D., Wang, G., Starkey, A., Hamilton, R. L., & Wiley, C. A. (2010a). In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. Journal of Neuroinflammation, 7, 34. https://doi.org/10.1186/1742-2094-7-34
Bonneh-Barkay, D., Zagadailov, P., Zou, H., Niyonkuru, C., Figley, M., Starkey, A., Wang, G., Bissel, S. J., Wiley, C. A., & Wagner, A. K. (2010b). YKL-40 expression in traumatic brain injury: An initial analysis. Journal of Neurotrauma, 27(7), 1215-1223. https://doi.org/10.1089/neu.2010.1310
Burman, J., Raininko, R., Blennow, K., Zetterberg, H., Axelsson, M., & Malmestrom, C. (2016). YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis. Journal of Neuroimmunology, 292, 52-57. https://doi.org/10.1016/j.jneuroim.2016.01.013
Bussink, A. P., Speijer, D., Aerts, J. M., & Boot, R. G. (2007). Evolution of mammalian chitinase(−like) members of family 18 glycosyl hydrolases. Genetics, 177(2), 959-970. https://doi.org/10.1534/genetics.107.075846
Cantó, E., Tintoré, M., Villar, L. M., Costa, C., Nurtdinov, R., Álvarez-Cermeño, J. C., Arrambide, G., Reverter, F., Deisenhammer, F., Hegen, H., Khademi, M., Olsson, T., Tumani, H., Rodríguez-Martín, E., Piehl, F., Bartos, A., Zimova, D., Kotoucova, J., Kuhle, J., … Comabella, M. (2015). Chitinase 3-like 1: Prognostic biomarker in clinically isolated syndromes. Brain, 138(Pt 4), 918-931. https://doi.org/10.1093/brain/awv017
Carabias, C. S., Gomez, P. A., Panero, I., Eiriz, C., Castaño-León, A. M., Egea, J., Lagares, A., & i+12 Neurotraumatology Group Collaborators. (2020). Chitinase-3-like protein 1, serum amyloid A1, C-reactive protein, and Procalcitonin are promising biomarkers for intracranial severity assessment of traumatic brain injury: Relationship with Glasgow coma scale and computed tomography Volumetry. World Neurosurgery, 134, e120-e143. https://doi.org/10.1016/j.wneu.2019.09.143
Chen, A., Jiang, Y., Li, Z., Wu, L., Santiago, U., Zou, H., Cai, C., Sharma, V., Guan, Y., McCarl, L., Ma, J., Wu, Y. L., Michel, J., Shi, Y., Konnikova, L., Amankulor, N. M., Zinn, P. O., Kohanbash, G., Agnihotri, S., … Hu, B. (2021). Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. The Journal of Clinical Investigation, 131(16), e147552. https://doi.org/10.1172/JCI147552
Chen, C. C., Pekow, J., Llado, V., Kanneganti, M., Lau, C. W., Mizoguchi, A., Mino-Kenudson, M., Bissonnette, M., & Mizoguchi, E. (2011). Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia. The American Journal of Pathology, 179(3), 1494-1503. https://doi.org/10.1016/j.ajpath.2011.05.038
Comabella, M., Deutschmann, C., Midaglia, L., Schierack, P., Martinez, J., Roggenbuck, D., & Montalban, X. (2021). Chitinase 3-like 1 is not a target antigen in patients with multiple sclerosis. Multiple Sclerosis, 27(9), 1455-1457. https://doi.org/10.1177/1352458520980141
Comabella, M., Fernández, M., Martin, R., Rivera-Vallvé, S., Borrás, E., Chiva, C., Julià, E., Rovira, A., Cantó, E., Alvarez-Cermeño, J. C., Villar, L. M., Tintoré, M., & Montalban, X. (2010). Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis. Brain, 133(Pt 4), 1082-1093. https://doi.org/10.1093/brain/awq035
Connolly, K., Lehoux, M., O'Rourke, R., Assetta, B., Erdemir, G. A., Elias, J. A., Lee, C. G., & Huang, Y. A. (2023). Potential role of chitinase-3-like protein 1 (CHI3L1/YKL-40) in neurodegeneration and Alzheimer's disease. Alzheimer's & Dementia, 19, 9-24. https://doi.org/10.1002/alz.12612
Corps, K. N., Roth, T. L., & McGavern, D. B. (2015). Inflammation and neuroprotection in traumatic brain injury. JAMA Neurology, 72(3), 355-362. https://doi.org/10.1001/jamaneurol.2014.3558
Costa, J., Gromicho, M., Pronto-Laborinho, A., Almeida, C., Gomes, R. A., Guerreiro, A. C. L., Oliva, A., Pinto, S., & de Carvalho, M. (2021). Cerebrospinal fluid Chitinases as biomarkers for amyotrophic lateral sclerosis. Diagnostics, 11(7), 1210. https://doi.org/10.3390/diagnostics11071210
Craig-Schapiro, R., Perrin, R. J., Roe, C. M., Xiong, C., Carter, D., Cairns, N. J., Mintun, M. A., Peskind, E. R., Li, G., Galasko, D. R., Clark, C. M., Quinn, J. F., D'Angelo, G., Malone, J. P., Townsend, R. R., Morris, J. C., Fagan, A. M., & Holtzman, D. M. (2010). YKL-40: A novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biological Psychiatry, 68(10), 903-912. https://doi.org/10.1016/j.biopsych.2010.08.025
Cubas-Núñez, L., Gil-Perotín, S., Castillo-Villalba, J., López, V., Solís Tarazona, L., Gasqué-Rubio, R., Carratalá-Boscá, S., Alcalá-Vicente, C., Pérez-Miralles, F., Lassmann, H., & Casanova, B. (2021). Potential role of CHI3L1+ astrocytes in progression in MS. Neurology Neuroimmunology & Neuroinflammation, 8(3), e972. https://doi.org/10.1212/NXI.0000000000000972
De Ceuninck, F., Pastoureau, P., Bouet, F., Bonnet, J., & Vanhoutte, P. M. (1998). Purification of Guinea pig YKL40 and modulation of its secretion by cultured articular chondrocytes. Journal of Cellular Biochemistry, 69(4), 414-424. https://doi.org/10.1002/(sici)1097-4644(19980615)69:4<414::aid-jcb3>3.0.co;2-q
Deng, X., Liu, Y., Luo, M., Wu, J., Ma, R., Wan, Q., & Wu, J. (2017). Circulating miRNA-24 and its target YKL-40 as potential biomarkers in patients with coronary heart disease and type 2 diabetes mellitus. Oncotarget, 8(38), 63038-63046. https://doi.org/10.18632/oncotarget.18593
Di Rosa, M., Distefano, G., Zorena, K., & Malaguarnera, L. (2016). Chitinases and immunity: Ancestral molecules with new functions. Immunobiology, 221(3), 399-411. https://doi.org/10.1016/j.imbio.2015.11.014
Dichev, V., Kazakova, M., & Sarafian, V. (2020). YKL-40 and neuron-specific enolase in neurodegeneration and neuroinflammation. Reviews in the Neurosciences, 31(5), 539-553. https://doi.org/10.1515/revneuro-2019-0100
Donder, A., & Ozdemir, H. H. (2021). Serum YKL-40 levels in patients with multiple sclerosis. Arquivos de Neuro-Psiquiatria, 79(9), 795-798. https://doi.org/10.1590/0004-282X-ANP-2020-0326
Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N. J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D. E., Bonvento, G., Butt, A. M., Chen, W. T., Cohen-Salmon, M., … Verkhratsky, A. (2021). Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience, 24(3), 312-325. https://doi.org/10.1038/s41593-020-00783-4
Faibish, M., Francescone, R., Bentley, B., Yan, W., & Shao, R. (2011). A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: A potential therapeutic agent in cancers. Molecular Cancer Therapeutics, 10(5), 742-751. https://doi.org/10.1158/1535-7163.MCT-10-0868
Fei, L., Chen, H., Ma, L., E, W., Wang, R., Fang, X., Zhou, Z., Sun, H., Wang, J., Jiang, M., Wang, X., Yu, C., Mei, Y., Jia, D., Zhang, T., Han, X., & Guo, G. (2022). Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development. Nature Genetics, 54(7), 1051-1061. https://doi.org/10.1038/s41588-022-01118-8
Ferrari-Souza, J. P., Ferreira, P. C. L., Bellaver, B., Tissot, C., Wang, Y. T., Leffa, D. T., Brum, W. S., Benedet, A. L., Ashton, N. J., de Bastiani, M. A., Rocha, A., Therriault, J., Lussier, F. Z., Chamoun, M., Servaes, S., Bezgin, G., Kang, M. S., Stevenson, J., Rahmouni, N., … Pascoal, T. A. (2022). Astrocyte biomarker signatures of amyloid-beta and tau pathologies in Alzheimer's disease. Molecular Psychiatry, 27(11), 4781-4789. https://doi.org/10.1038/s41380-022-01716-2
Fidoamore, A., Cristiano, L., Antonosante, A., d'Angelo, M., di Giacomo, E., Astarita, C., Giordano, A., Ippoliti, R., Benedetti, E., & Cimini, A. (2016). Glioblastoma stem cells microenvironment: The paracrine roles of the niche in drug and Radioresistance. Stem Cells International, 2016, 6809105. https://doi.org/10.1155/2016/6809105
Floro, S., Carandini, T., Pietroboni, A. M., De Riz, M. A., Scarpini, E., & Galimberti, D. (2022). Role of Chitinase 3-like 1 as a biomarker in multiple sclerosis: A systematic review and meta-analysis. Neurology Neuroimmunology & Neuroinflammation, 9(4), e1164. https://doi.org/10.1212/NXI.0000000000001164
Francescone, R. A., Scully, S., Faibish, M., Taylor, S. L., Oh, D., Moral, L., Yan, W., Bentley, B., & Shao, R. (2011). Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. The Journal of Biological Chemistry, 286(17), 15332-15343. https://doi.org/10.1074/jbc.M110.212514
Fusetti, F., Pijning, T., Kalk, K. H., Bos, E., & Dijkstra, B. W. (2003). Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. The Journal of Biological Chemistry, 278(39), 37753-37760. https://doi.org/10.1074/jbc.M303137200
Gao, Y. F., Zhu, T., Mao, C. X., Liu, Z. X., Wang, Z. B., Mao, X. Y., Li, L., Yin, J. Y., Zhou, H. H., & Liu, Z. Q. (2016). PPIC, EMP3 and CHI3L1 are novel prognostic markers for high grade glioma. International Journal of Molecular Sciences, 17(11), 1808. https://doi.org/10.3390/ijms17111808
Gaur, N., Perner, C., Witte, O. W., & Grosskreutz, J. (2020). The Chitinases as biomarkers for amyotrophic lateral sclerosis: Signals from the CNS and beyond. Frontiers in Neurology, 11, 377. https://doi.org/10.3389/fneur.2020.00377
Geng, B., Pan, J., Zhao, T., Ji, J., Zhang, C., Che, Y., Yang, J., Shi, H., Li, J., Zhou, H., Mu, X., Xu, C., Wang, C., Xu, Y., Liu, Z., Wen, H., & You, Q. (2018). Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through beta-catenin/Erk/Akt signaling in gastric cancer. Journal of Experimental & Clinical Cancer Research, 37(1), 208. https://doi.org/10.1186/s13046-018-0876-2
Gil-Perotin, S., Castillo-Villalba, J., Cubas-Nuñez, L., Gasque, R., Hervas, D., Gomez-Mateu, J., Alcala, C., Perez-Miralles, F., Gascon, F., Dominguez, J. A., & Casanova, B. (2019). Combined cerebrospinal fluid Neurofilament light chain protein and Chitinase-3 Like-1 levels in defining disease course and prognosis in multiple sclerosis. Frontiers in Neurology, 10, 1008. https://doi.org/10.3389/fneur.2019.01008
Gispert, J. D., Monté, G. C., Falcon, C., Tucholka, A., Rojas, S., Sánchez-Valle, R., Antonell, A., Lladó, A., Rami, L., & Molinuevo, J. L. (2016). CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD. Neurobiology of Aging, 38, 47-55. https://doi.org/10.1016/j.neurobiolaging.2015.10.022
Gray, E., Thompson, A. G., Wuu, J., Pelt, J., Talbot, K., Benatar, M., & Turner, M. R. (2020). CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis. Annals of Clinical Translational Neurology, 7(8), 1296-1306. https://doi.org/10.1002/acn3.51114
Guan, X., Hasan, M. N., Maniar, S., Jia, W., & Sun, D. (2018). Reactive astrocytes in glioblastoma Multiforme. Molecular Neurobiology, 55(8), 6927-6938. https://doi.org/10.1007/s12035-018-0880-8
Hai, L., Hoffmann, D. C., Mandelbaum, H., Xie, R., Ito, J., Jung, E., & Kessler, T. (2021). A connectivity signature for glioblastoma. bioRxiv. https://doi.org/10.1101/2021.11.07.465791
Hakala, B. E., White, C., & Recklies, A. D. (1993). Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. The Journal of Biological Chemistry, 268(34), 25803-25810.
Håkansson, I., Tisell, A., Cassel, P., Blennow, K., Zetterberg, H., Lundberg, P., Dahle, C., Vrethem, M., & Ernerudh, J. (2018). Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis. Journal of Neuroinflammation, 15(1), 209. https://doi.org/10.1186/s12974-018-1249-7
Han, X., Zhou, Z., Fei, L., Sun, H., Wang, R., Chen, Y., Chen, H., Wang, J., Tang, H., Ge, W., Zhou, Y., Ye, F., Jiang, M., Wu, J., Xiao, Y., Jia, X., Zhang, T., Ma, X., Zhang, Q., … Guo, G. (2020). Construction of a human cell landscape at single-cell level. Nature, 581(7808), 303-309. https://doi.org/10.1038/s41586-020-2157-4
Hao, Y., Liu, X., & Zhu, R. (2022). Neurodegeneration and glial activation related CSF biomarker as the diagnosis of Alzheimer's disease: A systematic review and an updated meta- analysis. Current Alzheimer Research, 19(1), 32-46. https://doi.org/10.2174/1567205018666211208142702
He, C. H., Lee, C. G., dela Cruz, C., Lee, C. M., Zhou, Y., Ahangari, F., Ma, B., Herzog, E. L., Rosenberg, S. A., Li, Y., Nour, A. M., Parikh, C. R., Schmidt, I., Modis, Y., Cantley, L., & Elias, J. A. (2013). Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor alpha2. Cell Reports, 4(4), 830-841. https://doi.org/10.1016/j.celrep.2013.07.032
Henrik Heiland, D., Ravi, V. M., Behringer, S. P., Frenking, J. H., Wurm, J., Joseph, K., Garrelfs, N. W. C., Strähle, J., Heynckes, S., Grauvogel, J., Franco, P., Mader, I., Schneider, M., Potthoff, A. L., Delev, D., Hofmann, U. G., Fung, C., Beck, J., Sankowski, R., … Schnell, O. (2019). Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma. Nature Communications, 10(1), 2541. https://doi.org/10.1038/s41467-019-10493-6
Hinsinger, G., Galéotti, N., Nabholz, N., Urbach, S., Rigau, V., Demattei, C., Lehmann, S., Camu, W., Labauge, P., Castelnovo, G., Brassat, D., Loussouarn, D., Salou, M., Laplaud, D., Casez, O., Bockaert, J., Marin, P., & Thouvenot, E. (2015). Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis. Multiple Sclerosis, 21(10), 1251-1261. https://doi.org/10.1177/1352458514561906
Huang, J., Gu, Z., Xu, Y., Jiang, L., Zhu, W., & Wang, W. (2021). CHI3L1 (Chitinase 3 like 1) upregulation is associated with macrophage signatures in esophageal cancer. Bioengineered, 12(1), 7882-7892. https://doi.org/10.1080/21655979.2021.1974654
Huss, A., Otto, M., Senel, M., Ludolph, A. C., Abdelhak, A., & Tumani, H. (2020). A score based on NfL and glial markers may differentiate between relapsing-remitting and progressive MS course. Frontiers in Neurology, 11, 608. https://doi.org/10.3389/fneur.2020.00608
Im, J. H., Yeo, I. J., Park, P. H., Choi, D. Y., Han, S. B., Yun, J., & Hong, J. T. (2020). Deletion of Chitinase-3-like 1 accelerates stroke development through enhancement of Neuroinflammation by STAT6-dependent M2 microglial inactivation in Chitinase-3-like 1 knockout mice. Experimental Neurology, 323, 113082. https://doi.org/10.1016/j.expneurol.2019.113082
Janelidze, S., Mattsson, N., Stomrud, E., Lindberg, O., Palmqvist, S., Zetterberg, H., Blennow, K., & Hansson, O. (2018). CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology, 91(9), e867-e877. https://doi.org/10.1212/WNL.0000000000006082
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019). Neuroinflammation: Friend and foe for ischemic stroke. Journal of Neuroinflammation, 16(1), 142. https://doi.org/10.1186/s12974-019-1516-2
Jiang, L., Xu, D., Zhang, W. J., Tang, Y., & Peng, Y. (2019). Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression. European Review for Medical and Pharmacological Sciences, 23(7), 3012-3020. https://doi.org/10.26355/eurrev_201904_17583
Jin, T., Lu, Y., He, Q. X., Wang, H., Li, B. F., Zhu, L. Y., & Xu, Q. Y. (2015). The role of MicroRNA, miR-24, and its target CHI3L1 in osteomyelitis caused by Staphylococcus aureus. Journal of Cellular Biochemistry, 116(12), 2804-2813. https://doi.org/10.1002/jcb.25225
Jingjing, Z., Nan, Z., Wei, W., Qinghe, G., Weijuan, W., Peng, W., & Xiangpeng, W. (2017). MicroRNA-24 modulates Staphylococcus aureus-induced macrophage polarization by suppressing CHI3L1. Inflammation, 40(3), 995-1005. https://doi.org/10.1007/s10753-017-0543-3
Johansen, J. S., Olee, T., Price, P. A., Hashimoto, S., Ochs, R. L., & Lotz, M. (2001). Regulation of YKL-40 production by human articular chondrocytes. Arthritis and Rheumatism, 44(4), 826-837. https://doi.org/10.1002/1529-0131(200104)44:4<826::AID-ANR139>3.0.CO;2-U
Junker, N., Johansen, J. S., Hansen, L. T., Lund, E. L., & Kristjansen, P. E. (2005). Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells. Cancer Science, 96(3), 183-190. https://doi.org/10.1111/j.1349-7006.2005.00026.x
Katz Sand, I. (2015). Classification, diagnosis, and differential diagnosis of multiple sclerosis. Current Opinion in Neurology, 28(3), 193-205. https://doi.org/10.1097/WCO.0000000000000206
Kawada, M., Seno, H., Kanda, K., Nakanishi, Y., Akitake, R., Komekado, H., Kawada, K., Sakai, Y., Mizoguchi, E., & Chiba, T. (2012). Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer. Oncogene, 31(26), 3111-3123. https://doi.org/10.1038/onc.2011.498
Kim, K. C., Yun, J., Son, D. J., Kim, J. Y., Jung, J. K., Choi, J. S., Kim, Y. R., Song, J. K., Kim, S. Y., Kang, S. K., Shin, D. H., Roh, Y. S., Han, S. B., & Hong, J. T. (2018). Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1. Theranostics, 8(16), 4409-4428. https://doi.org/10.7150/thno.26467
Kjaergaard, A. D., Johansen, J. S., Bojesen, S. E., & Nordestgaard, B. G. (2015). Elevated plasma YKL-40, lipids and lipoproteins, and ischemic vascular disease in the general population. Stroke, 46(2), 329-335. https://doi.org/10.1161/STROKEAHA.114.007657
Krawczyk, M. C., Haney, J. R., Pan, L., Caneda, C., Khankan, R. R., Reyes, S. D., Chang, J. W., Morselli, M., Vinters, H. V., Wang, A. C., Cobos, I., Gandal, M. J., Bergsneider, M., Kim, W., Liau, L. M., Yong, W., Jalali, A., Deneen, B., Grant, G. A., … Zhang, Y. (2022). Human astrocytes exhibit tumor microenvironment-, age-, and sex-related transcriptomic signatures. The Journal of Neuroscience, 42(8), 1587-1603. https://doi.org/10.1523/JNEUROSCI.0407-21.2021
Ku, B. M., Lee, Y. K., Ryu, J., Jeong, J. Y., Choi, J., Eun, K. M., Shin, H. Y., Kim, D. G., Hwang, E. M., Yoo, J. C., Park, J. Y., Roh, G. S., Kim, H. J., Cho, G. J., Choi, W. S., Paek, S. H., & Kang, S. S. (2011). CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. International Journal of Cancer, 128(6), 1316-1326. https://doi.org/10.1002/ijc.25466
Kusnierova, P., Zeman, D., Hradilek, P., Zapletalova, O., & Stejskal, D. (2020). Determination of chitinase 3-like 1 in cerebrospinal fluid in multiple sclerosis and other neurological diseases. PLoS One, 15(5), e0233519. https://doi.org/10.1371/journal.pone.0233519
Kzhyshkowska, J., Mamidi, S., Gratchev, A., Kremmer, E., Schmuttermaier, C., Krusell, L., Haus, G., Utikal, J., Schledzewski, K., Scholtze, J., & Goerdt, S. (2006). Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood, 107(8), 3221-3228. https://doi.org/10.1182/blood-2005-07-2843
Lananna, B. V., McKee, C. A., King, M. W., del Aguila, J., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., Elias, J. A., Zhang, J., Cruchaga, C., & Musiek, E. S. (2020). Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis. Science Translational Medicine, 12(574), eaax3519. https://doi.org/10.1126/scitranslmed.aax3519
Lane, C. A., Hardy, J., & Schott, J. M. (2018). Alzheimer's disease. European Journal of Neurology, 25(1), 59-70. https://doi.org/10.1111/ene.13439
Lassmann, H. (2018). Multiple sclerosis pathology. Cold Spring Harbor Perspectives in Medicine, 8(3), a028936. https://doi.org/10.1101/cshperspect.a028936
Lee, C. G., da Silva, C. A., dela Cruz, C., Ahangari, F., Ma, B., Kang, M. J., He, C. H., Takyar, S., & Elias, J. A. (2011). Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annual Review of Physiology, 73, 479-501. https://doi.org/10.1146/annurev-physiol-012110-142250
Lee, C. M., He, C. H., Nour, A. M., Zhou, Y., Ma, B., Park, J. W., Kim, K. H., dela Cruz, C., Sharma, L., Nasr, M. L., Modis, Y., Lee, C. G., & Elias, J. A. (2016). IL-13Ralpha2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Nature Communications, 7, 12752. https://doi.org/10.1038/ncomms12752
Lee, D. H., Kim, K. C., Hwang, C. J., Park, K. R., Jung, Y. S., Kim, S. Y., Kim, J. Y., Song, J. K., Song, M. J., Choi, M. K., Hwang, D. Y., Han, S. B., & Hong, J. T. (2019). Decreased lung tumor development in SwAPP mice through the downregulation of CHI3L1 and STAT 3 activity via the upregulation of miRNA342-3p. Molecular Therapy-Nucleic Acids, 16, 63-72. https://doi.org/10.1016/j.omtn.2019.02.007
Lee, H. G., Wheeler, M. A., & Quintana, F. J. (2022a). Function and therapeutic value of astrocytes in neurological diseases. Nature Reviews Drug Discovery, 21(5), 339-358. https://doi.org/10.1038/s41573-022-00390-x
Lee, Y. S., Yu, J. E., Kim, K. C., Lee, D. H., Son, D. J., Lee, H. P., Jung, J. K., Kim, N. D., Ham, Y. W., Yun, J., Han, S. B., & Hong, J. T. (2022b). A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL-13Ralpha2-mediated JNK-AP-1 signals. Molecular Oncology, 16(2), 508-526. https://doi.org/10.1002/1878-0261.13138
Li, J., Lin, J., Pan, Y., Wang, M., Meng, X., Li, H., Wang, Y., Zhao, X., Qin, H., Liu, L., Wang, Y., & CNSR-III Investigators. (2022). Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: Analysis of 6 inflammation biomarkers in a prospective cohort study. Journal of Neuroinflammation, 19(1), 131. https://doi.org/10.1186/s12974-022-02467-1
Li, X., Wu, X., Luo, P., & Xiong, L. (2020). Astrocyte-specific NDRG2 gene: Functions in the brain and neurological diseases. Cellular and Molecular Life Sciences, 77(13), 2461-2472. https://doi.org/10.1007/s00018-019-03406-9
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V. L., Dawson, T. M., … Barres, B. A. (2017). Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 541(7638), 481-487. https://doi.org/10.1038/nature21029
Liebelt, B. D., Shingu, T., Zhou, X., Ren, J., Shin, S. A., & Hu, J. (2016). Glioma stem cells: Signaling, microenvironment, and therapy. Stem Cells International, 2016, 7849890. https://doi.org/10.1155/2016/7849890
Liu, Z., & Chopp, M. (2016). Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke. Progress in Neurobiology, 144, 103-120. https://doi.org/10.1016/j.pneurobio.2015.09.008
Llorens, F., Thüne, K., Tahir, W., Kanata, E., Diaz-Lucena, D., Xanthopoulos, K., Kovatsi, E., Pleschka, C., Garcia-Esparcia, P., Schmitz, M., Ozbay, D., Correia, S., Correia, Â., Milosevic, I., Andréoletti, O., Fernández-Borges, N., Vorberg, I. M., Glatzel, M., Sklaviadis, T., … Zerr, I. (2017). YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias. Molecular Neurodegeneration, 12(1), 83. https://doi.org/10.1186/s13024-017-0226-4
Low, D., Subramaniam, R., Lin, L., Aomatsu, T., Mizoguchi, A., Ng, A., DeGruttola, A., Lee, C. G., Elias, J. A., Andoh, A., Mino-Kenudson, M., & Mizoguchi, E. (2015). Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9. Oncotarget, 6(34), 36535-36550. https://doi.org/10.18632/oncotarget.5440
Luo, L., Guan, X., Begum, G., Ding, D., Gayden, J., Hasan, M. N., Fiesler, V. M., Dodelson, J., Kohanbash, G., Hu, B., Amankulor, N. M., Jia, W., Castro, M. G., Sun, B., & Sun, D. (2020). Blockade of cell volume regulatory protein NKCC1 increases TMZ-induced glioma apoptosis and reduces Astrogliosis. Molecular Cancer Therapeutics, 19(7), 1550-1561. https://doi.org/10.1158/1535-7163.MCT-19-0910
Lyon, M. S., Wosiski-Kuhn, M., Gillespie, R., Caress, J., & Milligan, C. (2019). Inflammation, immunity, and amyotrophic lateral sclerosis: I etiology and pathology. Muscle Nerve, 59(1), 10-22. https://doi.org/10.1002/mus.26289
Ma, B., Akosman, B., Kamle, S., Lee, C. M., He, C. H., Koo, J. S., Lee, C. G., & Elias, J. A. (2021). CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor responses. The Journal of Clinical Investigation, 131(21), e137750. https://doi.org/10.1172/JCI137750
Matute-Blanch, C., Villar, L. M., Álvarez-Cermeño, J. C., Rejdak, K., Evdoshenko, E., Makshakov, G., Nazarov, V., Lapin, S., Midaglia, L., Vidal-Jordana, A., Drulovic, J., García-Merino, A., Sánchez-López, A. J., Havrdova, E., Saiz, A., Llufriu, S., Alvarez-Lafuente, R., Schroeder, I., Zettl, U. K., … Comabella, M. (2018). Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome. Brain, 141(4), 1085-1093. https://doi.org/10.1093/brain/awy021
Mavroudis, I., Chowdhury, R., Petridis, F., Karantali, E., Chatzikonstantinou, S., Balmus, I. M., Luca, I. S., Ciobica, A., & Kazis, D. (2021). YKL-40 as a potential biomarker for the differential diagnosis of Alzheimer's disease. Medicina, 58(1), 60. https://doi.org/10.3390/medicina58010060
Mazur, M., Zielinska, A., Grzybowski, M. M., Olczak, J., & Fichna, J. (2021). Chitinases and Chitinase-like proteins as therapeutic targets in inflammatory diseases, with a special focus on inflammatory bowel diseases. International Journal of Molecular Sciences, 22(13), 6966. https://doi.org/10.3390/ijms22136966
Miossec, P. (2003). Interleukin-17 in rheumatoid arthritis: If T cells were to contribute to inflammation and destruction through synergy. Arthritis and Rheumatism, 48(3), 594-601. https://doi.org/10.1002/art.10816
Mohanty, A. K., Choudhary, S., Kaushik, J. K., & Fisher, A. J. (2021). Crystal structure of breast regression protein 39 (BRP39), a signaling glycoprotein expressed during mammary gland apoptosis, at 2.6 a resolution. Journal of Structural Biology, 213(2), 107737. https://doi.org/10.1016/j.jsb.2021.107737
Momtazmanesh, S., Shobeiri, P., Saghazadeh, A., Teunissen, C. E., Burman, J., Szalardy, L., Klivenyi, P., Bartos, A., Fernandes, A., & Rezaei, N. (2021). Neuronal and glial CSF biomarkers in multiple sclerosis: A systematic review and meta-analysis. Reviews in the Neurosciences, 32(6), 573-595. https://doi.org/10.1515/revneuro-2020-0145
Moreno-Rodriguez, M., Perez, S. E., Nadeem, M., Malek-Ahmadi, M., & Mufson, E. J. (2020). Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease. Journal of Neuroinflammation, 17(1), 58. https://doi.org/10.1186/s12974-020-1723-x
Olee, T., Hashimoto, S., Quach, J., & Lotz, M. (1999). IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. Journal of Immunology, 162(2), 1096-1100.
Olsson, B., Constantinescu, R., Holmberg, B., Andreasen, N., Blennow, K., & Zetterberg, H. (2013). The glial marker YKL-40 is decreased in synucleinopathies. Movement Disorders, 28(13), 1882-1885. https://doi.org/10.1002/mds.25589
Omuro, A., Brandes, A. A., Carpentier, A. F., Idbaih, A., Reardon, D. A., Cloughesy, T., Sumrall, A., Baehring, J., van den Bent, M., Bähr, O., Lombardi, G., Mulholland, P., Tabatabai, G., Lassen, U., Sepulveda, J. M., Khasraw, M., Vauleon, E., Muragaki, Y., di Giacomo, A. M., … Weller, M. (2023). Radiotherapy combined with Nivolumab or Temozolomide for newly diagnosed glioblastoma with Unmethylated MGMT promoter: An international randomized phase 3 trial. Neuro-Oncology, 25, 123-134. https://doi.org/10.1093/neuonc/noac099
Ostrom, Q. T., Bauchet, L., Davis, F. G., Deltour, I., Fisher, J. L., Langer, C. E., Pekmezci, M., Schwartzbaum, J. A., Turner, M. C., Walsh, K. M., Wrensch, M. R., & Barnholtz-Sloan, J. S. (2014). The epidemiology of glioma in adults: A "state of the science" review. Neuro-Oncology, 16(7), 896-913. https://doi.org/10.1093/neuonc/nou087
Park, H. Y., Jun, C. D., Jeon, S. J., Choi, S. S., Kim, H. R., Choi, D. B., Kwak, S., Lee, H. S., Cheong, J. S., So, H. S., Lee, Y. J., & Park, D. S. (2012). Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients. PLoS One, 7(12), e51722. https://doi.org/10.1371/journal.pone.0051722
Pérez-Miralles, F., Prefasi, D., García-Merino, A., Gascón-Giménez, F., Medrano, N., Castillo-Villalba, J., Cubas, L., Alcalá, C., Gil-Perotín, S., Gómez-Ballesteros, R., Maurino, J., Álvarez-García, E., & Casanova, B. (2020). CSF chitinase 3-like-1 association with disability of primary progressive MS. Neurology Neuroimmunology & Neuroinflammation, 7(5), e815. https://doi.org/10.1212/NXI.0000000000000815
Pinteac, R., Montalban, X., & Comabella, M. (2021). Chitinases and chitinase-like proteins as biomarkers in neurologic disorders. Neurology Neuroimmunology & Neuroinflammation, 8(1), e921. https://doi.org/10.1212/NXI.0000000000000921
Placone, A. L., Quinones-Hinojosa, A., & Searson, P. C. (2016). The role of astrocytes in the progression of brain cancer: Complicating the picture of the tumor microenvironment. Tumour Biology, 37(1), 61-69. https://doi.org/10.1007/s13277-015-4242-0
Prakash, M., Bodas, M., Prakash, D., Nawani, N., Khetmalas, M., Mandal, A., & Eriksson, C. (2013). Diverse pathological implications of YKL-40: Answers may lie in 'outside-in' signaling. Cellular Signalling, 25(7), 1567-1573. https://doi.org/10.1016/j.cellsig.2013.03.016
Qin, G., Li, X., Chen, Z., Liao, G., Su, Y., Chen, Y., & Zhang, W. (2017). Prognostic value of YKL-40 in patients with glioblastoma: A systematic review and meta-analysis. Molecular Neurobiology, 54(5), 3264-3270. https://doi.org/10.1007/s12035-016-9878-2
Querol-Vilaseca, M., Colom-Cadena, M., Pegueroles, J., San Martín-Paniello, C., Clarimon, J., Belbin, O., Fortea, J., & Lleó, A. (2017). YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies. Journal of Neuroinflammation, 14(1), 118. https://doi.org/10.1186/s12974-017-0893-7
Quintana, E., Coll, C., Salavedra-Pont, J., Muñoz-San Martín, M., Robles-Cedeño, R., Tomàs-Roig, J., Buxó, M., Matute-Blanch, C., Villar, L. M., Montalban, X., Comabella, M., Perkal, H., Gich, J., & Ramió-Torrentà, L. (2018). Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain. European Journal of Neurology, 25(9), 1189-1191. https://doi.org/10.1111/ene.13687
Rathcke, C. N., Thomsen, S. B., Linneberg, A., & Vestergaard, H. (2012). Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke. PLoS One, 7(8), e43498. https://doi.org/10.1371/journal.pone.0043498
Ruiz, F., Vigne, S., & Pot, C. (2019). Resolution of inflammation during multiple sclerosis. Seminars in Immunopathology, 41(6), 711-726. https://doi.org/10.1007/s00281-019-00765-0
Samii, A., Nutt, J. G., & Ransom, B. R. (2004). Parkinson's disease. Lancet, 363(9423), 1783-1793. https://doi.org/10.1016/S0140-6736(04)16305-8
Sanfilippo, C., Longo, A., Lazzara, F., Cambria, D., Distefano, G., Palumbo, M., Cantarella, A., Malaguarnera, L., & di Rosa, M. (2017). CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients. Molecular and Cellular Neurosciences, 85, 162-169. https://doi.org/10.1016/j.mcn.2017.10.001
Sarma, N. J., Tiriveedhi, V., Subramanian, V., Shenoy, S., Crippin, J. S., Chapman, W. C., & Mohanakumar, T. (2012). Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway. PLoS One, 7(11), e50826. https://doi.org/10.1371/journal.pone.0050826
Schmid, D., Warnken, U., Latzer, P., Hoffmann, D. C., Roth, J., Kutschmann, S., Jaschonek, H., Rübmann, P., Foltyn, M., Vollmuth, P., Winkler, F., Seliger, C., Felix, M., Sahm, F., Haas, J., Reuss, D., Bendszus, M., Wildemann, B., von Deimling, A., … Kessler, T. (2021). Diagnostic biomarkers from proteomic characterization of cerebrospinal fluid in patients with brain malignancies. Journal of Neurochemistry, 158(2), 522-538. https://doi.org/10.1111/jnc.15350
Schneider, R., Bellenberg, B., Gisevius, B., Hirschberg, S., Sankowski, R., Prinz, M., Gold, R., Lukas, C., & Haghikia, A. (2021). Chitinase 3-like 1 and neurofilament light chain in CSF and CNS atrophy in MS. Neurology Neuroimmunology & Neuroinflammation, 8(1), e906. https://doi.org/10.1212/NXI.0000000000000906
Sellebjerg, F., Royen, L., Soelberg Sorensen, P., Oturai, A. B., & Jensen, P. E. H. (2019). Prognostic value of cerebrospinal fluid neurofilament light chain and chitinase-3-like-1 in newly diagnosed patients with multiple sclerosis. Multiple Sclerosis, 25(11), 1444-1451. https://doi.org/10.1177/1352458518794308
Shao, R., Francescone, R., Ngernyuang, N., Bentley, B., Taylor, S. L., Moral, L., & Yan, W. (2014). Anti-YKL-40 antibody and ionizing irradiation synergistically inhibit tumor vascularization and malignancy in glioblastoma. Carcinogenesis, 35(2), 373-382. https://doi.org/10.1093/carcin/bgt380
Shao, R., Taylor, S. L., Oh, D. S., & Schwartz, L. M. (2015). Vascular heterogeneity and targeting: The role of YKL-40 in glioblastoma vascularization. Oncotarget, 6(38), 40507-40518. https://doi.org/10.18632/oncotarget.5943
Singh, S. K., Bhardwaj, R., Wilczynska, K. M., Dumur, C. I., & Kordula, T. (2011). A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40. The Journal of Biological Chemistry, 286(46), 39893-39903. https://doi.org/10.1074/jbc.M111.257451
Sofroniew, M. V., & Vinters, H. V. (2010). Astrocytes: Biology and pathology. Acta Neuropathologica, 119(1), 7-35. https://doi.org/10.1007/s00401-009-0619-8
Swash, M. (2020). Chitinases, neuroinflammation and biomarkers in ALS. Journal of Neurology, Neurosurgery, and Psychiatry, 91(4), 338. https://doi.org/10.1136/jnnp-2019-322520
Tamam, Y., Gunes, B., Akbayir, E., Kizilay, T., Karaaslan, Z., Koral, G., Duzel, B., Kucukali, C. I., Gunduz, T., Kurtuncu, M., Yilmaz, V., Tuzun, E., & Turkoglu, R. (2021). CSF levels of HoxB3 and YKL-40 may predict conversion from clinically isolated syndrome to relapsing remitting multiple sclerosis. Multiple Sclerosis and Related Disorders, 48, 102697. https://doi.org/10.1016/j.msard.2020.102697
Thompson, A. G., Gray, E., Bampton, A., Raciborska, D., Talbot, K., & Turner, M. R. (2019). CSF chitinase proteins in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry, 90(11), 1215-1220. https://doi.org/10.1136/jnnp-2019-320442
Thonhoff, J. R., Simpson, E. P., & Appel, S. H. (2018). Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis. Current Opinion in Neurology, 31(5), 635-639. https://doi.org/10.1097/WCO.0000000000000599
Thouvenot, E., Hinsinger, G., Demattei, C., Uygunoglu, U., Castelnovo, G., Pittion-Vouyovitch, S., Okuda, D., Kantarci, O., Pelletier, D., Lehmann, S., Marin, P., Siva, A., & Lebrun, C. (2019). Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome. Multiple Sclerosis, 25(5), 669-677. https://doi.org/10.1177/1352458518767043
Urbanaviciute, R., Skauminas, K., & Skiriute, D. (2020). The evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN serum combined value in astrocytic glioma Patients' diagnosis and prognosis. Brain Sciences, 10(11), 872. https://doi.org/10.3390/brainsci10110872
Vega, K., & Kalkum, M. (2012). Chitin, chitinase responses, and invasive fungal infections. International Journal of Microbiology, 2012, 920459. https://doi.org/10.1155/2012/920459
Vu, L., An, J., Kovalik, T., Gendron, T., Petrucelli, L., & Bowser, R. (2020). Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes. Journal of Neurology, Neurosurgery, and Psychiatry, 91(4), 350-358. https://doi.org/10.1136/jnnp-2019-321916
Wang, J., Su, H. K., Zhao, H. F., Chen, Z. P., & To, S. S. (2015). Progress in the application of molecular biomarkers in gliomas. Biochemical and Biophysical Research Communications, 465(1), 1-4. https://doi.org/10.1016/j.bbrc.2015.07.148
Wennstrom, M., Surova, Y., Hall, S., Nilsson, C., Minthon, L., Hansson, O., & Nielsen, H. M. (2015). The inflammatory marker YKL-40 is elevated in cerebrospinal fluid from patients with Alzheimer's but not Parkinson's disease or dementia with Lewy bodies. PLoS One, 10(8), e0135458. https://doi.org/10.1371/journal.pone.0135458
Wiley, C. A., Bonneh-Barkay, D., Dixon, C. E., Lesniak, A., Wang, G., Bissel, S. J., & Kochanek, P. M. (2015). Role for mammalian chitinase 3-like protein 1 in traumatic brain injury. Neuropathology, 35(2), 95-106. https://doi.org/10.1111/neup.12158
Wood, M. D., Mukherjee, J., & Pieper, R. O. (2018). Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro. Scientific Reports, 8(1), 5805. https://doi.org/10.1038/s41598-018-24046-2
Woollacott, I. O. C., Nicholas, J. M., Heller, C., Foiani, M. S., Moore, K. M., Russell, L. L., Paterson, R. W., Keshavan, A., Schott, J. M., Warren, J. D., Heslegrave, A., Zetterberg, H., & Rohrer, J. D. (2020). Cerebrospinal fluid YKL-40 and Chitotriosidase levels in frontotemporal dementia vary by clinical, genetic and pathological subtype. Dementia and Geriatric Cognitive Disorders, 49(1), 56-76. https://doi.org/10.1159/000506282
Wurm, J., Behringer, S. P., Ravi, V. M., Joseph, K., Neidert, N., Maier, J. P., Doria-Medina, R., Follo, M., Delev, D., Pfeifer, D., Beck, J., Sankowski, R., Schnell, O., & Heiland, D. H. (2019). Astrogliosis releases pro-oncogenic Chitinase 3-like 1 causing MAPK signaling in glioblastoma. Cancers, 11(10), 1437. https://doi.org/10.3390/cancers11101437
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X. F., & Achong, M. K. (1998). IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. The Journal of Clinical Investigation, 101(2), 311-320. https://doi.org/10.1172/JCI1368
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012). Genomic analysis of reactive astrogliosis. The Journal of Neuroscience, 32(18), 6391-6410. https://doi.org/10.1523/JNEUROSCI.6221-11.2012
Zhang, Z., Zhou, Q., Luo, F., Zhou, R., Xu, J., Xiao, J., Dai, F., & Song, L. (2021). Circular RNA circ-CHI3L1.2 modulates cisplatin resistance of osteosarcoma cells via the miR-340-5p/LPAATbeta axis. Human Cell, 34(5), 1558-1568. https://doi.org/10.1007/s13577-021-00564-6
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 201. https://doi.org/10.1038/s41392-020-00303-7