Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
Adult onset
Children and adolescents
Prodromal symptoms
Prodrome
Schizophrenia, bipolar disorder, early onset
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
07 Apr 2023
07 Apr 2023
Historique:
received:
18
03
2022
accepted:
10
03
2023
entrez:
7
4
2023
pubmed:
8
4
2023
medline:
8
4
2023
Statut:
aheadofprint
Résumé
To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7-35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33-177] vs. 58 [21-140] days; Z = - 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31-155] vs. 30 [7-66] days; Z = - 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.
Identifiants
pubmed: 37027026
doi: 10.1007/s00787-023-02196-7
pii: 10.1007/s00787-023-02196-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI08/0208
Organisme : Instituto de Salud Carlos III
ID : PI18/0242
Organisme : Instituto de Salud Carlos III
ID : INT19-00021
Organisme : Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya
ID : 2017SGR1355
Investigateurs
Clemente García-Rizo
(C)
Jairo González-Díaz
(J)
Mario de Matteis
(M)
Héctor de Diego
(H)
Eva Grasa
(E)
Alejandra Roldán
(A)
Iñaki Zorrilla
(I)
Edurne García-Corres
(E)
Pedro M Ruíz-Lázaro
(PM)
Concepción de-la-Cámara
(C)
Olga Rivero
(O)
María José Escarti
(MJ)
Francesc Casanovas
(F)
Alba Toll
(A)
Norma Verdolini
(N)
Maria Sagué-Vilabella
(M)
Gisela Sugranyes
(G)
Daniel Ilzarbe
(D)
Fernando Contreras
(F)
Leticia González-Blanco
(L)
María Paz García-Portilla
(MP)
Miguel Gutierrez
(M)
Arantzazu Zabala
(A)
Roberto Rodríguez-Jiménez
(R)
Luis Sánchez-Pastor
(L)
Judith Usall
(J)
Anna Butjosa
(A)
Edith Pomarol
(E)
Salvador Sarró
(S)
Angela Ibáñez
(A)
Ana Maria Sánchez-Torres
(AM)
Vicent Balanzá-Martínez
(V)
Informations de copyright
© 2023. The Author(s).
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