Association of common infections with cognitive performance in the Baltimore Epidemiologic Catchment Area study follow-up.
Alzheimer's disease
cognition
herpes
infection
toxoplasma
virus
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
26
01
2023
received:
19
10
2022
accepted:
27
01
2023
pmc-release:
01
11
2024
medline:
16
11
2023
pubmed:
8
4
2023
entrez:
7
4
2023
Statut:
ppublish
Résumé
Growing evidence suggests that some common infections are causally associated with cognitive impairment; however, less is known about the burden of multiple infections. We investigated the cross-sectional association of positive antibody tests for herpes simplex virus, cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zoster virus (VZV), and Toxoplasma gondii (TOX) with Mini-Mental State Examination (MMSE) and delayed verbal recall performance in 575 adults aged 41-97 from the Baltimore Epidemiologic Catchment Area Study. In multivariable-adjusted zero-inflated Poisson (ZIP) regression models, positive antibody tests for CMV (p = .011) and herpes simplex virus (p = .018) were individually associated with poorer MMSE performance (p = .011). A greater number of positive antibody tests among the five tested was associated with worse MMSE performance (p = .001). CMV, herpes simplex virus, and the global burden of multiple common infections were independently associated with poorer cognitive performance. Additional research that investigates whether the global burden of infection predicts cognitive decline and Alzheimer's disease biomarker changes is needed to confirm these findings.
Identifiants
pubmed: 37027458
doi: 10.1002/alz.13070
pmc: PMC10558626
mid: NIHMS1888480
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4841-4851Subventions
Organisme : NIA NIH HHS
ID : R01AG075996
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG065171
Pays : United States
Organisme : NIMH NIH HHS
ID : MH 47447
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103538
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH047447
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052445
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG075996
Pays : United States
Organisme : NIA NIH HHS
ID : U01AG052445
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG065171
Pays : United States
Informations de copyright
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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