Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19.
Humans
Cell Line
Cellular Senescence
/ drug effects
Circadian Clocks
/ drug effects
Circadian Rhythm
/ drug effects
CLOCK Proteins
/ genetics
Dexamethasone
/ pharmacology
Hydrogen Peroxide
/ pharmacology
Phagocytosis
/ drug effects
Retinal Degeneration
/ metabolism
Retinal Pigment Epithelium
/ cytology
Time Factors
ARPE-19
Age-related retinal degeneration
Circadian rhythm
Phagocytosis
RPE
Retinal pigment epithelium
Senescence
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
28 05 2023
28 05 2023
Historique:
received:
05
03
2023
accepted:
29
03
2023
medline:
21
4
2023
pubmed:
8
4
2023
entrez:
7
4
2023
Statut:
ppublish
Résumé
Renewal of retinal photoreceptor outer segments is conducted through daily shedding of distal photoreceptor outer segment tips and subsequent their phagocytosis by the adjacent retinal pigment epithelium (RPE) monolayer. Dysregulation of the diurnal clearance of photoreceptor outer segment tips has been implicated in age-related retinal degeneration, but it remains to be clarified how the circadian phagocytic activity of RPE cells is modulated by senescence. In this study, we used the human RPE cell line ARPE-19 to investigate whether hydrogen peroxide (H
Identifiants
pubmed: 37027909
pii: S0006-291X(23)00370-4
doi: 10.1016/j.bbrc.2023.03.070
pii:
doi:
Substances chimiques
CLOCK Proteins
EC 2.3.1.48
Dexamethasone
7S5I7G3JQL
Hydrogen Peroxide
BBX060AN9V
NR1D1 protein, human
0
SR9009
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-96Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflicts of interest with the contents of this article.