Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
05
09
2022
accepted:
14
03
2023
revised:
10
03
2023
medline:
29
6
2023
pubmed:
8
4
2023
entrez:
7
4
2023
Statut:
ppublish
Résumé
Obesity in pregnancy associates with changes in the glucose-insulin axis. We hypothesized that these changes affect the maternal metabolome already in the first trimester of human pregnancy and, thus, aimed to identify these metabolites. We performed untargeted metabolomics (HPLC-MS/MS) on maternal serum (n = 181, gestational weeks 4 We detected 2449 serum features of which 277 were annotated. After stringent analysis, 15 metabolites associated with at least one exposure (BMI, leptin, glucose, C-peptide, IS We conclude that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy because of associated changes of C-peptide. Changes of palmitoleoyl ethanolamide concentration in pregnant women with obesity-associated hyperinsulinemia may reflect dysfunctional endocannabinoid-like signalling.
Sections du résumé
BACKGROUND/OBJECTIVES
Obesity in pregnancy associates with changes in the glucose-insulin axis. We hypothesized that these changes affect the maternal metabolome already in the first trimester of human pregnancy and, thus, aimed to identify these metabolites.
PATIENTS/METHODS
We performed untargeted metabolomics (HPLC-MS/MS) on maternal serum (n = 181, gestational weeks 4
RESULTS
We detected 2449 serum features of which 277 were annotated. After stringent analysis, 15 metabolites associated with at least one exposure (BMI, leptin, glucose, C-peptide, IS
CONCLUSIONS
We conclude that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy because of associated changes of C-peptide. Changes of palmitoleoyl ethanolamide concentration in pregnant women with obesity-associated hyperinsulinemia may reflect dysfunctional endocannabinoid-like signalling.
Identifiants
pubmed: 37029207
doi: 10.1038/s41366-023-01295-4
pii: 10.1038/s41366-023-01295-4
pmc: PMC10299907
doi:
Substances chimiques
Leptin
0
C-Peptide
0
Endocannabinoids
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529-537Informations de copyright
© 2023. The Author(s).
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