Population screening for 15q11-q13 duplications: corroboration of the difference in impact between maternally and paternally inherited alleles.


Journal

European journal of human genetics : EJHG
ISSN: 1476-5438
Titre abrégé: Eur J Hum Genet
Pays: England
ID NLM: 9302235

Informations de publication

Date de publication:
07 Apr 2023
Historique:
received: 21 12 2022
accepted: 09 03 2023
revised: 28 02 2023
entrez: 7 4 2023
pubmed: 8 4 2023
medline: 8 4 2023
Statut: aheadofprint

Résumé

Maternally inherited 15q11-q13 duplications are generally found to cause more severe neurodevelopmental anomalies compared to paternally inherited duplications. However, this assessment is mainly inferred from the study of patient populations, causing an ascertainment bias towards patients at the more severe end of the phenotypic spectrum. Here, we analyze the low coverage genome-wide cell-free DNA sequencing data obtained from pregnant women during non-invasive prenatal screening (NIPS). We detect 23 15q11-q13 duplications in 333,187 pregnant women (0.0069%), with an approximately equal distribution between maternal and paternal duplications. Maternally inherited duplications are always associated with a clinical phenotype (ranging from learning difficulties to intellectual impairment, epilepsy and psychiatric disorders), while paternal duplications are normal or associated with milder phenotypes (mild learning difficulties and dyslexia). This data corroborates the difference in impact between paternally and maternally inherited 15q11-q13 duplications, contributing to the improvement of genetic counselling. We recommend reporting 15q11-q13 duplications identified during genome-wide NIPS with appropriate genetic counselling for these pregnant women in the interest of both mothers and future children.

Identifiants

pubmed: 37029316
doi: 10.1038/s41431-023-01336-6
pii: 10.1038/s41431-023-01336-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to European Society of Human Genetics.

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Auteurs

Ilse Parijs (I)

Center for Human Genetics, University Hospitals Leuven-KU Leuven, Leuven, Belgium.

Nathalie Brison (N)

Center for Human Genetics, University Hospitals Leuven-KU Leuven, Leuven, Belgium.

Leen Vancoillie (L)

Center for Human Genetics, University Hospitals Leuven-KU Leuven, Leuven, Belgium.

Machteld Baetens (M)

Center of Medical Genetics, University Hospital Ghent, Ghent, Belgium.

Bettina Blaumeiser (B)

Center of Medical Genetics, University and University Hospital Antwerp, Antwerp, Belgium.

Sébastien Boulanger (S)

Center for Medical Genetics, Institut de Pathologie et de Génétique Gosselies, Charleroi, Belgium.

Julie Désir (J)

Center for Medical Genetics, Institut de Pathologie et de Génétique Gosselies, Charleroi, Belgium.

Boyan Dimitrov (B)

Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Clinical Sciences, research group Reproduction and Genetics, Center for Medical Genetics, Brussels, Belgium.

Nathalie Fieremans (N)

Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Clinical Sciences, research group Reproduction and Genetics, Center for Medical Genetics, Brussels, Belgium.

Katrien Janssens (K)

Center of Medical Genetics, University and University Hospital Antwerp, Antwerp, Belgium.

Sandra Janssens (S)

Center of Medical Genetics, University Hospital Ghent, Ghent, Belgium.

Axel Marichal (A)

Center for Medical Genetics, Institut de Pathologie et de Génétique Gosselies, Charleroi, Belgium.

Björn Menten (B)

Center of Medical Genetics, University Hospital Ghent, Ghent, Belgium.

Colombine Meunier (C)

Center for Medical Genetics, Institut de Pathologie et de Génétique Gosselies, Charleroi, Belgium.

Kim Van Berkel (K)

Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Clinical Sciences, research group Reproduction and Genetics, Center for Medical Genetics, Brussels, Belgium.

Ann Van Den Bogaert (A)

Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Clinical Sciences, research group Reproduction and Genetics, Center for Medical Genetics, Brussels, Belgium.

Koenraad Devriendt (K)

Center for Human Genetics, University Hospitals Leuven-KU Leuven, Leuven, Belgium.

Kris Van Den Bogaert (K)

Center for Human Genetics, University Hospitals Leuven-KU Leuven, Leuven, Belgium.

Joris Robert Vermeesch (JR)

Center for Human Genetics, University Hospitals Leuven-KU Leuven, Leuven, Belgium. Joris.Vermeesch@uzleuven.be.

Classifications MeSH