Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa?
Cancer stem cells
Dysplasia
Malignant transformation
Oral cancer
Precancerous stem cells
Journal
Cellular & molecular biology letters
ISSN: 1689-1392
Titre abrégé: Cell Mol Biol Lett
Pays: England
ID NLM: 9607427
Informations de publication
Date de publication:
07 Apr 2023
07 Apr 2023
Historique:
received:
24
10
2022
accepted:
20
03
2023
medline:
11
4
2023
entrez:
7
4
2023
pubmed:
8
4
2023
Statut:
epublish
Résumé
Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. This apparently contradictory feature may be the foundation of the reversible transformation of precancerous lesions. Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. Currently available clinical assays for chromosomal instability and DNA aneuploidy have several deficiencies. We hope that our study will increase attention to pCSC research and lead to the development of novel strategies for the prevention and treatment of oral cancer by identifying pCSC markers.
Identifiants
pubmed: 37029348
doi: 10.1186/s11658-023-00441-0
pii: 10.1186/s11658-023-00441-0
pmc: PMC10080963
doi:
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
30Informations de copyright
© 2023. The Author(s).
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