Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2).

Adult Female Humans Young Adult Life Change Events Obesity / complications Weight Gain Body Mass Index Risk Factors Weight Loss Endometrial Neoplasms / epidemiology
BMI BMI change Endometrial cancer epidemiology gynaecology life course exposures obesity uterine cancer weight change weight loss

Journal

International journal of epidemiology
ISSN: 1464-3685
Titre abrégé: Int J Epidemiol
Pays: England
ID NLM: 7802871

Informations de publication

Date de publication:
02 08 2023
Historique:
received: 04 08 2022
accepted: 04 04 2023
medline: 4 8 2023
pubmed: 9 4 2023
entrez: 8 4 2023
Statut: ppublish

Résumé

Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18-21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR = 2.85, 95% CI = 2.47-3.29) and young adulthood (OR = 1.26, 95% CI = 1.06-1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

Sections du résumé

BACKGROUND
Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18-21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2).
METHODS
We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes.
RESULTS
We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR = 2.85, 95% CI = 2.47-3.29) and young adulthood (OR = 1.26, 95% CI = 1.06-1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics.
CONCLUSIONS
Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

Identifiants

DOI: 10.1093/ije/dyad046 PMID: 37029916 PMC: PMC10396409
pubmed: 37029916
pii: 7111259
doi: 10.1093/ije/dyad046
pmc: PMC10396409
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1086-1099

Subventions

Organisme : NCI NIH HHS
ID : U01 CA250476
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA169888
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058420
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164974
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA199277
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA164917
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA077398
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : NU58DP006344
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201800032I
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201800015I
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201800009I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA105212
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA082838
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010126
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA092585
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA202979
Pays : United States

Informations de copyright

Published by Oxford University Press on behalf of the International Epidemiological Association 2023.

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Auteurs

Summer V Harvey (SV)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
ORCID: 0000-0001-7829-7842

Nicolas Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Kimberly Bertrand (K)

Slone Epidemiology Center, at Boston University, Boston, MA, USA.
ORCID: 0000-0002-4565-7618

Amanda Black (A)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Louise A Brinton (LA)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Chu Chen (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Laura Costas (L)

Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Luigino Dal Maso (L)

Cancer Epidemiology Unit, Centro di Riferimento Oncologico, Aviano, Italy.
ORCID: 0000-0001-6163-200X

Immaculata De Vivo (I)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Mengmeng Du (M)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Montserrat Garcia-Closas (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Marc T Goodman (MT)

Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jessica Gorzelitz (J)

Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA.

Lisa Johnson (L)

Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.

James V Lacey (JV)

Division of Health Analytics, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

Linda Liao (L)

Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA.

Loren Lipworth (L)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Jolanta Lissowska (J)

Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Anthony B Miller (AB)

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

Kelli O'Connell (K)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tracy A O'Mara (TA)

Cancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Xiao Ou (X)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Julie R Palmer (JR)

Slone Epidemiology Center, at Boston University, Boston, MA, USA.

Alpa V Patel (AV)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Sonia Paytubi (S)

Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.

Beatriz Pelegrina (B)

Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Stacey Petruzella (S)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Anna Prizment (A)

Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.

Thomas Rohan (T)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Sven Sandin (S)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-6994-4884

Veronica Wendy Setiawan (VW)

Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Rashmi Sinha (R)

Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA.

Britton Trabert (B)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
ORCID: 0000-0002-1539-6090

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
ORCID: 0000-0003-0733-5930

Lynne R Wilkens (LR)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Wanghong Xu (W)

Department of Epidemiology, Fudan University School of Public Health, Shanghai, China.
ORCID: 0000-0003-2045-2218

Hannah P Yang (HP)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0003-1226-070X

Megan A Clarke (MA)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Associations of life course obesity with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations of life course obesity with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Associations of life course obesity with...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Événements de vie › Associations of life course obesity with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Associations of life course obesity with...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Prise de poids › Associations of life course obesity with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Associations of life course obesity with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Associations of life course obesity with...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Perte de poids › Associations of life course obesity with...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs de l'endomètre › Associations of life course obesity with...