Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder
PM2.5
adipose tissue
lipid metabolism
mitochondria
multiomics
young mice
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
12
2022
accepted:
02
03
2023
medline:
11
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
epublish
Résumé
Air pollution has become one of the most serious health risks as a result of industrialization, especially in developing countries. More attention has been drawn to the relationship between obesity/overweight and fine particulate matter (PM2.5). Especially for susceptible populations, the impact of air pollution on children and adolescents has attracted more public attentions. However, the detailed underlying mechanism influencing obesity or overweight under PM2.5 exposure is still unknown. Therefore, young mice were exposed to PM2.5 using the real-ambient exposure system that we previously established in Shijiazhuang city. Compared with the traditionally concentrated air particle (CAP) system, our real-ambient exposure system provides similar PM2.5 concentrations and characteristics as outdoor ambient air and minimizes the influence of external interfering factors. After 8 weeks of exposure to PM2.5, the weight of gonadal white adipose tissue (gWAT) and subcutaneous white adipose tissue (sWAT) was considerably increased, accompanied by a significantly enlarged size of adipocytes in sWAT. Importantly, multiomics analysis indicated altered metabolites involved in the lipid metabolism pathway, and transcriptomic analysis revealed notably changed signaling pathways related to fatty acid metabolism. Moreover, the mtDNA copy number, mitochondrial activity and fatty acid oxidation (FAO) were increased in the liver under PM2.5 exposure. Taken together, our research investigated the hypotrophy of adipose tissue in young mice, supported an imbalance in lipid metabolism based on multiomics analysis, and revealed disordered mitochondrial function under PM2.5 exposure. Our study provided new insight into the hazardous effects of air pollution, and extended our understanding on the underlying mechanism.
Identifiants
pubmed: 37033660
doi: 10.3389/fphar.2023.1122615
pii: 1122615
pmc: PMC10079078
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1122615Informations de copyright
Copyright © 2023 Si, Gao, Yang, Zhu, Han, Li, Wang, Li, Zhao, Chen, Zheng and Jiang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Environ Res. 2018 Oct;166:713-725
pubmed: 29880237
Rev Environ Health. 2008 Oct-Dec;23(4):243-97
pubmed: 19235364
FEBS J. 2015 Feb;282(4):647-72
pubmed: 25495651
Environ Int. 2019 Sep;130:104935
pubmed: 31238265
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2323-4
pubmed: 21084700
J Nat Med. 2021 Jun;75(3):540-552
pubmed: 33590347
Environ Res. 2020 Jun;185:109364
pubmed: 32247148
Oncotarget. 2016 May 17;7(20):29255-74
pubmed: 27081083
Endocrinology. 2020 Apr 1;161(4):
pubmed: 32060542
Annu Rev Food Sci Technol. 2018 Mar 25;9:345-381
pubmed: 29350557
Lancet Diabetes Endocrinol. 2021 Jun;9(6):373-392
pubmed: 34022156
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):
pubmed: 33836591
Environ Pollut. 2022 Jan 1;292(Pt B):118464
pubmed: 34763019
Part Fibre Toxicol. 2020 Jun 5;17(1):22
pubmed: 32503629
J Hepatol. 2016 May;64(5):1176-1186
pubmed: 26829204
Paediatr Perinat Epidemiol. 2012 Nov;26(6):561-71
pubmed: 23061692
Sci Total Environ. 2020 Aug 15;730:138652
pubmed: 32416500
Adv Exp Med Biol. 2017;982:465-520
pubmed: 28551803
Environ Int. 2019 Jan;122:193-200
pubmed: 30446244
Curr Environ Health Rep. 2014 Aug 8;1:258-274
pubmed: 25152864
Front Public Health. 2022 Mar 22;10:843622
pubmed: 35392463
Nat Rev Mol Cell Biol. 2019 Jun;20(6):353-367
pubmed: 30814649
J Hazard Mater. 2021 Jul 15;414:125504
pubmed: 33652219
Circ Res. 2011 Mar 18;108(6):686-94
pubmed: 21273556
Prostaglandins Leukot Essent Fatty Acids. 2011 Jul;85(1):37-41
pubmed: 21530211
Annu Rev Physiol. 2016;78:23-44
pubmed: 26474213
Front Pharmacol. 2020 Mar 31;11:199
pubmed: 32296328
Cell Mol Life Sci. 2018 Sep;75(18):3313-3327
pubmed: 29936596
Clin Chim Acta. 2021 Mar;514:29-33
pubmed: 33279503
Chemosphere. 2020 May;247:125881
pubmed: 31978653
Nanotoxicology. 2018 Nov;12(9):1045-1067
pubmed: 30257117
Exp Mol Med. 2016 Mar 11;48:e218
pubmed: 26964834
Free Radic Biol Med. 2016 Oct;99:259-272
pubmed: 27554971
Eur J Clin Nutr. 2013 Aug;67(8):855-62
pubmed: 23612517
J Clin Invest. 2016 Jan;126(1):12-22
pubmed: 26727229
Nat Rev Mol Cell Biol. 2019 Apr;20(4):242-258
pubmed: 30610207
Pharmacol Ther. 2021 Mar;219:107705
pubmed: 33039420
PLoS One. 2015 Aug 20;10(8):e0135749
pubmed: 26291610
Annu Rev Clin Psychol. 2020 May 7;16:351-378
pubmed: 32097572
Environ Pollut. 2019 May;248:874-887
pubmed: 30856503
Ann N Y Acad Sci. 2008 Oct;1140:163-83
pubmed: 18991915
Sci Total Environ. 2019 Aug 10;677:215-229
pubmed: 31055101
Int J Environ Res Public Health. 2021 Feb 17;18(4):
pubmed: 33671274
J Hazard Mater. 2020 Oct 5;397:122608
pubmed: 32387827
Environ Health Perspect. 2019 Dec;127(12):127008
pubmed: 31873044
Part Fibre Toxicol. 2022 Jun 23;19(1):42
pubmed: 35739565
Environ Health Perspect. 2020 Jun;128(6):67009
pubmed: 32579081
Front Pharmacol. 2021 Apr 23;12:662664
pubmed: 33967806
Sci Total Environ. 2022 May 15;821:153456
pubmed: 35093369
J Am Coll Cardiol. 2018 Oct 23;72(17):2054-2070
pubmed: 30336830
Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):160-174
pubmed: 30518830
Neuro Endocrinol Lett. 2020 Sep;41(3):146-153
pubmed: 33201649
J Hazard Mater. 2015 Apr 28;287:392-401
pubmed: 25677476
Circ Res. 2019 Dec 6;125(12):1103-1105
pubmed: 31804911
Toxicol Sci. 2011 Nov;124(1):88-98
pubmed: 21873646
Int J Mol Sci. 2014 May 15;15(5):8713-42
pubmed: 24837835
Semin Cell Dev Biol. 2020 Dec;108:65-71
pubmed: 32201132
J Pineal Res. 2021 Jan;70(1):e12686
pubmed: 32730639
Eur J Clin Nutr. 1999 Apr;53 Suppl 1:S53-65
pubmed: 10365981
Gastroenterology. 2018 Sep;155(3):629-647
pubmed: 30012333
Annu Rev Biochem. 2014;83:79-98
pubmed: 24606142
Compr Physiol. 2017 Dec 12;8(1):1-8
pubmed: 29357123
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Dec;31(12):1555-1558
pubmed: 32029051
Sci Transl Med. 2020 Dec 2;12(572):
pubmed: 33268508
Ecotoxicol Environ Saf. 2019 Jan 15;167:178-187
pubmed: 30336408
Environ Int. 2019 Dec;133(Pt A):105180
pubmed: 31622905
Hepatology. 2022 Jan;75(1):125-139
pubmed: 34387896
Environ Res. 2018 Jan;160:479-486
pubmed: 29078141
PLoS One. 2013;8(1):e51588
pubmed: 23359794