SARS-CoV-2
CLCC1
COVID-19
SARS-CoV-2
Unfolded protein response
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
10
2022
accepted:
24
02
2023
medline:
11
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
epublish
Résumé
Understanding the interactions between SARS-CoV-2 and host cell machinery may reveal new targets to treat COVID-19. We focused on an interaction between the SARS-CoV-2 ORF3A accessory protein and the CLIC-like chloride channel-1 (CLCC1). We found that ORF3A partially co-localized with CLCC1 and that ORF3A and CLCC1 could be co-immunoprecipitated. Since CLCC1 plays a role in the unfolded protein response (UPR), we hypothesized that ORF3A may also play a role in the UPR. Indeed, ORF3A expression triggered a transcriptional UPR that was similar to knockdown of
Identifiants
pubmed: 37033725
doi: 10.7717/peerj.15077
pii: 15077
pmc: PMC10078464
doi:
Substances chimiques
Chloride Channels
0
CLCC1 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15077Subventions
Organisme : NIDDK NIH HHS
ID : U24 DK116214
Pays : United States
Informations de copyright
©2023 Gruner et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
Références
Biol Cell. 2021 Jul;113(7):311-328
pubmed: 33666950
J Comput Biol. 2013 Dec;20(12):970-8
pubmed: 23961961
J Neurosci. 2015 Feb 18;35(7):3001-9
pubmed: 25698737
Cell Metab. 2012 Aug 8;16(2):250-64
pubmed: 22883233
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Cell Metab. 2012 Aug 8;16(2):265-73
pubmed: 22883234
Hum Mol Genet. 2012 Mar 1;21(5):963-77
pubmed: 22045699
Int J Mol Sci. 2020 Sep 03;21(17):
pubmed: 32899231
Nat Commun. 2021 Sep 20;12(1):5536
pubmed: 34545074
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
PLoS One. 2009 Dec 17;4(12):e8342
pubmed: 20020050
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Nat Protoc. 2016 Sep;11(9):1650-67
pubmed: 27560171
Neurochem Res. 2018 Feb;43(2):340-350
pubmed: 29090408
J Biol Chem. 2012 Sep 14;287(38):31994-2005
pubmed: 22854956
J Gen Virol. 2005 Jul;86(Pt 7):1921-1930
pubmed: 15958670
Cell. 2001 Dec 28;107(7):881-91
pubmed: 11779464
Signal Transduct Target Ther. 2021 Mar 15;6(1):123
pubmed: 33723219
Cell. 2020 Aug 6;182(3):685-712.e19
pubmed: 32645325
Sci Rep. 2021 Aug 25;11(1):17146
pubmed: 34433867
PLoS Genet. 2018 Aug 29;14(8):e1007504
pubmed: 30157172
J Biol Chem. 2001 Jun 8;276(23):20413-8
pubmed: 11279057
IUBMB Life. 2022 Jan;74(1):93-100
pubmed: 34390301
Nucleic Acids Res. 2019 Jan 8;47(D1):D419-D426
pubmed: 30407594
FASEB J. 2019 Aug;33(8):8865-8877
pubmed: 31034780
Nucleic Acids Res. 2019 Jan 8;47(D1):D330-D338
pubmed: 30395331
Science. 2013 Feb 15;339(6121):823-6
pubmed: 23287722
Cell Mol Immunol. 2020 Aug;17(8):881-883
pubmed: 32555321
Dev Cell. 2021 Feb 22;56(4):427-442.e5
pubmed: 33422265
J Virol. 2010 Jan;84(2):1097-109
pubmed: 19889773
J Virol. 2021 Aug 10;95(17):e0040221
pubmed: 34133899
Mol Cell Biol. 2006 Dec;26(24):9220-31
pubmed: 17030611
J Biol Chem. 2017 Dec 8;292(49):19952-19958
pubmed: 29084849
Nature. 2002 Jan 3;415(6867):92-6
pubmed: 11780124
Annu Rev Pathol. 2015;10:173-94
pubmed: 25387057
FEBS Lett. 2015 Jun 4;589(13):1450-8
pubmed: 25957766