Impact of antioxidants in improving semen parameters like count, motility and DNA fragmentation in sub-fertile males: a randomized, double-blind, placebo-controlled clinical trial.
Antioxidant
Asthenoteratozoospermia
DNA Fragmentation
Oligospermia
Subfertility
Journal
Translational and clinical pharmacology
ISSN: 2289-0882
Titre abrégé: Transl Clin Pharmacol
Pays: Korea (South)
ID NLM: 101639331
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
04
01
2023
revised:
24
02
2023
accepted:
12
03
2023
medline:
11
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
ppublish
Résumé
Male infertility is solely responsible for 20-30% of infertility cases. Oxidative damage of sperm DNA is positively linked with oligoasthenoteratozoospermia (OAT), and male infertility. The antioxidants are being explored worldwide to combat OAT, sperm DNA fragmentation and reactive oxygen species. The objective of the study was to assess the effectiveness of an antioxidant blend in improving sperm count, semen parameters and reducing DNA fragmentation index (DFI) in sub-fertile males. A prospective, double-blind, randomized, placebo-controlled trial was conducted in 300 sub-fertile males (25-45 years) from ten study sites in India. Subjects were randomized in either the antioxidant blend treatment group or placebo group. We assessed changes in sperm count, motility, normal morphology, semen volume, and percent DFI before and after treatment (90 days). To further stratify data on different criteria Clinical Trials Registry-India Identifier: CTRI/2020/12/029590.
Identifiants
pubmed: 37034126
doi: 10.12793/tcp.2023.31.e6
pmc: PMC10079508
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28-39Informations de copyright
Copyright © 2023 Translational and Clinical Pharmacology.
Déclaration de conflit d'intérêts
Conflict of Interest: - Authors: Rohit Shelatkar is a part of Vitabiotics UK. Meyer Organics Pvt. Ltd. is a group company of Vitabiotics. Other authors declare no conflict of interest - Reviewers: Nothing to declare - Editors: Nothing to declare
Références
Fertil Steril. 2005 Sep;84(3):662-71
pubmed: 16169400
J Med Food. 2006 Fall;9(3):440-2
pubmed: 17004914
Andrologia. 2020 Jul;52(6):e13570
pubmed: 32271472
Cochrane Database Syst Rev. 2011 Jan 19;(1):CD007411
pubmed: 21249690
Andrologia. 2019 Jul;51(6):e13267
pubmed: 30873633
Reprod Biol Endocrinol. 2015 Apr 26;13:37
pubmed: 25928197
Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4
pubmed: 3666872
J Clin Endocrinol Metab. 2018 Mar 1;103(3):870-881
pubmed: 29126319
Int J Reprod Biomed. 2016 Dec;14(12):729-736
pubmed: 28066832
Asian J Androl. 2022 Jan-Feb;24(1):40-44
pubmed: 34121749
Hum Reprod Update. 2015 Jul-Aug;21(4):455-85
pubmed: 25888788
Syst Biol Reprod Med. 2009 Mar-Apr;55(2):109-15
pubmed: 19462290
Indian J Community Med. 2019 Oct-Dec;44(4):337-341
pubmed: 31802796
Reprod Biomed Online. 2013 Oct;27(4):325-37
pubmed: 23948450
Transl Androl Urol. 2017 Sep;6(Suppl 4):S649-S653
pubmed: 29082954
Rev Urol. 2011;13(4):e184-90
pubmed: 22232567
Nutr Rev. 2016 Feb;74(2):118-30
pubmed: 26705308
Andrologia. 2017 Dec;49(10):
pubmed: 28124476
J Clin Med. 2021 Jul 23;10(15):
pubmed: 34362038
Indian J Urol. 2017 Jul-Sep;33(3):207-214
pubmed: 28717270
Andrologia. 2018 Apr;50(3):
pubmed: 29315686
J Assist Reprod Genet. 2015 Apr;32(4):509-20
pubmed: 25646893
Reprod Biomed Online. 2007 Apr;14(4):418-21
pubmed: 17425820