Clinical and Cytokine Profile of Children With COVID-19: A Report From Turkey.
covid-19
inflammatory cytokines
pediatric patient
pro-bnp
severe cases
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
accepted:
04
04
2023
medline:
11
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
epublish
Résumé
Background We aimed to analyze the expression of infection-related biomarkers and inflammatory cytokines in laboratory-confirmed cases and compare the differences between clinically severe and non-severe ones. Method We randomly selected 35 patients who were hospitalized with the diagnosis of coronavirus disease 2019 (COVID-19). Blood serum was obtained at the time of admission to the hospital, on the third to the fifth day, and at the time of discharge. Result The median age of our patients was 56.5±69.7 months (range: 1-205 months). The mean pro-B-type natriuretic peptide (pro-BNP) was significantly higher at the time of admission than on the third to the fifth day of illness. The mean pro-B-type natriuretic peptide levels at three time points were significantly higher in patients with severe cases than in mild-moderate cases. However, there was no significant difference between the clinical severity with regard to the cytokine levels at disease onset and recovery. Conclusion In the study, it was shown that cytokines play an important role in the pathogenesis of COVID-19. Therefore, it may be beneficial to use agents such as tocilizumab in the treatment.
Identifiants
pubmed: 37034144
doi: 10.7759/cureus.37139
pmc: PMC10078166
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e37139Informations de copyright
Copyright © 2023, Dalkıran et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Clin Chem Lab Med. 2020 Jun 25;58(7):1135-1138
pubmed: 32172227
JAMA Cardiol. 2020 Jul 1;5(7):811-818
pubmed: 32219356
Clin Infect Dis. 2020 Sep 12;71(6):1547-1551
pubmed: 32112072
Int J Antimicrob Agents. 2020 Mar;55(3):105924
pubmed: 32081636
Pediatrics. 2020 Jun;145(6):
pubmed: 32179660
N Engl J Med. 2020 Apr 23;382(17):1663-1665
pubmed: 32187458
J Microbiol Immunol Infect. 2020 Jun;53(3):371-372
pubmed: 32147409
Respirology. 2013 Aug;18(6):889-90
pubmed: 23714366
N Engl J Med. 2020 Mar 19;382(12):1177-1179
pubmed: 32074444
J Infect Dis. 2020 May 11;221(11):1775-1781
pubmed: 32179908
J Rheumatol. 1993 May;20(5):803-8
pubmed: 8336306
JAMA. 2020 Apr 7;323(13):1313-1314
pubmed: 32058570
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Turk J Med Sci. 2020 Apr 18;50(SI-1):592-603
pubmed: 32304191
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Lancet Child Adolesc Health. 2020 Jun;4(6):414-416
pubmed: 32458804
Emerg Med J. 2011 Feb;28(2):122-7
pubmed: 20511643
J Bras Pneumol. 2019 Aug 12;45(4):e20180417
pubmed: 31411279
Zhonghua Er Ke Za Zhi. 2020 Mar 2;58(3):169-174
pubmed: 32135584
Respir Res. 2020 Apr 15;21(1):83
pubmed: 32293449
Cureus. 2022 Jun 21;14(6):e26141
pubmed: 35747110
Zhonghua Er Ke Za Zhi. 2020 Mar 2;58(3):179-182
pubmed: 32135586
Pediatr Res. 2020 Sep;88(3):340-341
pubmed: 32244248
World J Pediatr. 2020 Jun;16(3):223-231
pubmed: 32034659
J Infect. 2020 Aug;81(2):e11-e15
pubmed: 32360500
Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L217-30
pubmed: 24318116