Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension.
hypertension
immunity
inflammation
lymphocytes
mass cytometry
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
25
05
2022
revised:
12
09
2022
accepted:
12
09
2022
medline:
11
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
epublish
Résumé
Evidence from nonhuman animal models demonstrates an important role for immune cells in hypertension, but immune cell changes in human hypertension are less clear. Using mass cytometry, we demonstrate novel and selective reductions in CCR10
Identifiants
pubmed: 37034287
doi: 10.1016/j.jacbts.2022.09.007
pii: S2452-302X(22)00365-5
pmc: PMC10077123
doi:
Types de publication
Journal Article
Langues
eng
Pagination
319-336Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL153786
Pays : United States
Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
This work was supported in part by VICTR grant VR54365, funded by Vanderbilt Clinical and Translational Science Award (CTSA) grant UL1TR002243 from the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). Support was provided to Dr Irish by VANTAGE at Vanderbilt, funded by CTSA grant 5UL1 RR024975-03), the Vanderbilt Ingram Cancer Center (grant P30 CA68485), the Vanderbilt Vision Center (grant P30 EY08126), the National Center for Research Resources, NIH (grant G20 RR030956), and grants for single-cell analysis (R01CA226833, U01AI125056, and U54CA217450). Support was also provided by the National Heart, Lung, and Blood Institute, NIH (grants 1F32HL144048 and K08HL153786 to Dr Alexander and DP2HL137166 to Dr Madhur) and the American Heart Association (grant EIA34480023 to Dr Madhur). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Références
Hypertension. 2010 Feb;55(2):500-7
pubmed: 20038749
Nat Immunol. 2021 Jun;22(6):746-756
pubmed: 34031618
Clin Cancer Res. 2018 Sep 1;24(17):4175-4186
pubmed: 29437767
Genome Biol. 2014;15(12):550
pubmed: 25516281
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14470-5
pubmed: 10588729
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Immunol Rev. 2011 May;241(1):260-8
pubmed: 21488902
Stem Cells. 2006 Dec;24(12):2810-6
pubmed: 16931770
J Immunol. 1997 May 15;158(10):4642-53
pubmed: 9144476
Circulation. 2011 Sep 20;124(12):1370-81
pubmed: 21875910
N Engl J Med. 2019 Dec 26;381(26):2497-2505
pubmed: 31733140
PLoS One. 2018 May 14;13(5):e0197178
pubmed: 29758052
J Am Coll Cardiol. 2018 May 15;71(19):2199-2269
pubmed: 29146533
Nucleic Acids Res. 2019 Jul 2;47(W1):W199-W205
pubmed: 31114916
Lancet. 2020 Oct 17;396(10258):1223-1249
pubmed: 33069327
Nat Methods. 2017 Sep;14(9):865-868
pubmed: 28759029
Blood. 2007 Mar 1;109(5):2058-65
pubmed: 17110462
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
J Hypertens. 2016 Jan;34(1):97-108
pubmed: 26630215
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13439-44
pubmed: 19666573
Clin Transl Immunology. 2017 Jan 20;6(1):e126
pubmed: 28197337
J Clin Invest. 2020 Dec 1;130(12):6261-6277
pubmed: 32817592
Nat Immunol. 2021 Aug;22(8):1008-1019
pubmed: 34312545
J Clin Invest. 2014 Oct;124(10):4642-56
pubmed: 25244096
Nat Rev Nephrol. 2020 Apr;16(4):223-237
pubmed: 32024986
Nat Rev Immunol. 2010 Jan;10(1):36-46
pubmed: 19960040
Circ Res. 2021 Apr 2;128(7):908-933
pubmed: 33793336
Immunity. 2007 Oct;27(4):670-84
pubmed: 17950003
Hypertension. 2013 Jul;62(1):126-33
pubmed: 23716586
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17570-5
pubmed: 24101470
Hypertension. 2011 Mar;57(3):469-76
pubmed: 21263125
Nat Med. 2002 Feb;8(2):157-65
pubmed: 11821900
Protein Cell. 2012 Aug;3(8):571-80
pubmed: 22684736
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Nucleic Acids Res. 2021 Jan 8;49(D1):D545-D551
pubmed: 33125081
J Allergy Clin Immunol. 2014 Sep;134(3):634-644.e10
pubmed: 24767879
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
Cell. 2015 Jul 2;162(1):184-97
pubmed: 26095251
Curr Opin Immunol. 2018 Apr;51:187-196
pubmed: 29655022
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Cytometry A. 2013 May;83(5):483-94
pubmed: 23512433
JCI Insight. 2019 Apr 23;5:
pubmed: 31013256
Hypertension. 2001 Jan;37(1):77-83
pubmed: 11208760
J Hypertens. 2020 Apr;38(4):692-700
pubmed: 31834124
J Virol. 2011 May;85(9):4184-97
pubmed: 21307196
Immunity. 2016 Aug 16;45(2):389-401
pubmed: 27521269
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Curr Hypertens Rep. 2021 Mar 5;23(3):13
pubmed: 33666761
Trends Mol Med. 2010 Jun;16(6):247-56
pubmed: 20493774
Front Immunol. 2018 Mar 23;9:585
pubmed: 29662491
Methods Mol Biol. 2015;1346:99-113
pubmed: 26542718
N Engl J Med. 2019 Feb 21;380(8):752-762
pubmed: 30415610
Circulation. 2009 Jun 9;119(22):2904-12
pubmed: 19470887
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Cancer Immunol Res. 2016 Jan;4(1):61-71
pubmed: 26464015
Hypertension. 2016 Jul;68(1):123-32
pubmed: 27217403
Front Immunol. 2018 Nov 09;9:2569
pubmed: 30473697
J Am Heart Assoc. 2015 Nov 20;4(11):
pubmed: 26588944
Circulation. 2020 Apr 21;141(16):1307-1317
pubmed: 32148083
Eur Heart J. 2019 Nov 1;40(42):3459-3470
pubmed: 31504461
Hypertension. 2014 Nov;64(5):1108-15
pubmed: 25259750
Semin Immunopathol. 2019 May;41(3):327-337
pubmed: 30989321
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4571-6
pubmed: 17360565
PLoS Comput Biol. 2016 Sep 23;12(9):e1005112
pubmed: 27662185
JAMA. 2020 Sep 22;324(12):1190-1200
pubmed: 32902588