Viral and Host Mediators of Non-Suppressible HIV-1 Viremia.

CD8 immune response HIV integration non-suppressible viremia persistent low-level viremia producer provirus

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
31 Mar 2023
Historique:
pubmed: 11 4 2023
medline: 11 4 2023
entrez: 10 4 2023
Statut: epublish

Résumé

Non-suppressible HIV-1 viremia (NSV) can occur in persons with HIV despite adherence to combination antiretroviral therapy (ART) and in the absence of significant drug resistance. Here, we show that plasma NSV sequences are comprised primarily of large clones without evidence of viral evolution over time. We defined proviruses that contribute to plasma viremia as "producer", and those that did not as "non-producer". Compared to ART-suppressed individuals, NSV participants had a significantly larger producer reservoir. Producer proviruses were enriched in chromosome 19 and in proximity to the activating H3K36me3 epigenetic mark. CD4

Identifiants

DOI: 10.1101/2023.03.30.23287124 PMID: 37034605 PMC: PMC10081408
pubmed: 37034605
doi: 10.1101/2023.03.30.23287124
pmc: PMC10081408
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R37 AI039394
Pays : United States
Organisme : NIAID NIH HHS
ID : U54 AI170791
Pays : United States

Commentaires et corrections

Type : UpdateIn

Auteurs

Abbas Mohammadi (A)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Behzad Etemad (B)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Xin Zhang (X)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Yijia Li (Y)

University of Pittsburgh, Pittsburgh, PA, USA.

Gregory J Bedwell (GJ)

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Radwa Sharaf (R)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Autumn Kittilson (A)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Meghan Melberg (M)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Colline Wong (C)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Jesse Fajnzylber (J)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Daniel P Worrall (DP)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Alex Rosenthal (A)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Hannah Jordan (H)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Nikolaus Jilg (N)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Clarety Kaseke (C)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Francoise Giguel (F)

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Xiaodong Lian (X)

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Rinki Deo (R)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Elisabeth Gillespie (E)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Rida Chishti (R)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Sara Abrha (S)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Taylor Adams (T)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abigail Siagian (A)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Peter L Anderson (PL)

Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Steven G Deeks (SG)

Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.

Michael M Lederman (MM)

Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Sigal Yawetz (S)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Daniel R Kuritzkes (DR)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Mathias D Lichterfeld (MD)

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Athe Tsibris (A)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Mary Carrington (M)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Zabrina L Brumme (ZL)

Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.

Jose R Castillo-Mancilla (JR)

Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Alan N Engelman (AN)

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Gaurav D Gaiha (GD)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

Jonathan Z Li (JZ)

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Classifications MeSH