Activity-dependent constraints on catecholamine signaling.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
31 Mar 2023
Historique:
pubmed: 11 4 2023
medline: 11 4 2023
entrez: 10 4 2023
Statut: epublish

Résumé

Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity

Identifiants

DOI: 10.1101/2023.03.30.534970 PMID: 37034631 PMC: PMC10081217
pubmed: 37034631
doi: 10.1101/2023.03.30.534970
pmc: PMC10081217
pii:
doi:

Types de publication

Preprint

Langues

eng

Auteurs

Li Li (L)

Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
Seattle Children's Hospital, Seattle WA 98145, USA.

Akshay Rana (A)

Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
Equal contribution.

Esther M Li (EM)

Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
Department of Psychology, University of Washington, Seattle WA 98105, USA.
Equal contribution.

Jiesi Feng (J)

State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.

Yulong Li (Y)

State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

Michael R Bruchas (MR)

Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
Department of Bioengineering, University of Washington, Seattle WA 98105, USA.
Department of Pharmacology, University of Washington, Seattle WA 98195, USA.

Classifications MeSH