Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
31 Mar 2023
Historique:
pubmed: 11 4 2023
medline: 11 4 2023
entrez: 10 4 2023
Statut: epublish

Résumé

Development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. Current strategies for developing pan-coronavirus countermeasures have largely focused on the receptor binding domain (

Identifiants

DOI: 10.1101/2023.03.28.534602 PMID: 37034676 PMC: PMC10081229
pubmed: 37034676
doi: 10.1101/2023.03.28.534602
pmc: PMC10081229
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI144462
Pays : United States

Déclaration de conflit d'intérêts

Competing interests D.B.J., B.A.A., M.J.T.S., and W.J.M. were employees and shareholders of 10x Genomics, Inc. at the time this work was performed. D.B.J., B.A.A., M.J.T.S., and W.J.M. are inventors on patents in relation to algorithms, therapeutic candidates, and other components of this work.

Auteurs

Jonathan Hurtado (J)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Thomas F Rogers (TF)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

David B Jaffe (DB)

10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.

Bruce A Adams (BA)

10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.

Sandhya Bangaru (S)

Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.

Elijah Garcia (E)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Tazio Capozzola (T)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Terrence Messmer (T)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Pragati Sharma (P)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Ge Song (G)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Nathan Beutler (N)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Wanting He (W)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Katharina Dueker (K)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Rami Musharrafieh (R)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Michael J T Stubbington (MJT)

10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.

Dennis R Burton (DR)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ragon Institute of MGH, Harvard and MIT, Cambridge, MA 02139, USA.

Raiees Andrabi (R)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Andrew B Ward (AB)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.
IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

Wyatt J McDonnell (WJ)

10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.

Bryan Briney (B)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Classifications MeSH