APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
29 Mar 2023
Historique:
medline: 11 4 2023
entrez: 10 4 2023
pubmed: 11 4 2023
Statut: epublish

Résumé

HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4 HIV-1 Vif neutralizes the HIV-1 restriction activity of A3 proteins. However, it is currently unclear whether Vif has additional essential cellular targets. To address this question, we disrupted

Identifiants

pubmed: 37034786
doi: 10.1101/2023.03.28.534666
pmc: PMC10081227
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R37 AI064046
Pays : United States

Commentaires et corrections

Type : UpdateIn

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Auteurs

Terumasa Ikeda (T)

Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto 8600811, Japan.

Ryo Shimizu (R)

Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto 8600811, Japan.
Graduate School of Medical Sciences, Kumamoto University, Kumamoto 8600811, Japan.

Hesham Nasser (H)

Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto 8600811, Japan.
Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia 41511, Egypt.

Michael A Carpenter (MA)

Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, USA.
Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas 78229, USA.

Adam Z Cheng (AZ)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA.

William L Brown (WL)

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Daniel Sauter (D)

Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen 72076, Germany.

Reuben S Harris (RS)

Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229, USA.
Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas 78229, USA.

Classifications MeSH