The relationship between residential exposure to atmospheric pollution and circulating miRNA in adults living in an urban area in northern France.
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
12
12
2022
revised:
04
03
2023
accepted:
29
03
2023
medline:
28
4
2023
pubmed:
11
4
2023
entrez:
10
4
2023
Statut:
ppublish
Résumé
MicroRNAs are epigenetic regulatory factors capable of silencing the expression of target genes and might mediate the effects of air pollution on health. The objective of the present population-based study was to investigate the association between microRNA expression and long-term, residential exposure to atmospheric PM We included 998 non-smoking adult participants from the cross-sectional ELISABET survey (2010-2014) in the Lille urban area of France. The mean residential annual pollution levels were estimated with an atmospheric dispersion modelling system. Ten microRNAs were selected on the basis of the literature data, together with two housekeeping microRNAs (miR-93-5p and miR-191-5p) and were quantified with RT-qPCRs. Multivariate linear regression models were used to study the association between microRNAs and air pollution. The threshold for statistical significance (after correction for the FDR) was set to p < 0.1. The mean annual exposure between 2011 and the year of inclusion was 26.4 ± 2.0 µg/m Our results suggest that circulating miRNAs are potentially valuable biomarkers of the effects of air pollution.
Identifiants
pubmed: 37037173
pii: S0160-4120(23)00186-1
doi: 10.1016/j.envint.2023.107913
pii:
doi:
Substances chimiques
Nitrogen Dioxide
S7G510RUBH
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107913Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.