Dormancy in Breast Cancer.

Animals Mice Humans Female Breast Neoplasms / genetics Neoplasm Recurrence, Local

Journal

Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139

Informations de publication

Date de publication:
01 Nov 2023
Historique:
pmc-release: 10 10 2024
medline: 3 11 2023
pubmed: 11 4 2023
entrez: 10 4 2023
Statut: epublish

Résumé

The pattern of delayed recurrence in a subset of breast cancer patients has long been explained by a model that incorporates a variable period of cellular or tumor mass dormancy prior to disease relapse. In this review, we critically evaluate existing data to develop a framework for inferring the existence of dormancy in clinical contexts of breast cancer. We integrate these clinical data with rapidly evolving mechanistic insights into breast cancer dormancy derived from a broad array of genetically engineered mouse models as well as experimental models of metastasis. Finally, we propose actionable interventions and discuss ongoing clinical trials that translate the wealth of knowledge gained in the laboratory to the long-term clinical management of patients at a high risk of developing recurrence.

Identifiants

DOI: 10.1101/cshperspect.a041331 PMID: 37037598 PMC: PMC10562521
pubmed: 37037598
pii: cshperspect.a041331
doi: 10.1101/cshperspect.a041331
pmc: PMC10562521
mid: NIHMS1897327
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R03 CA259656
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218024
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA109182
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA253977
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA143296
Pays : United States

Informations de copyright

Copyright © 2023 Cold Spring Harbor Laboratory Press; all rights reserved.

Auteurs

Erica Dalla (E)

Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Department of Oncological Sciences, Black Family Stem Cell Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Amulya Sreekumar (A)

Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Julio A Aguirre-Ghiso (JA)

Department of Cell Biology, Department of Oncology, Cancer Dormancy and Tumor Microenvironment Institute, Montefiore Einstein Cancer Center, Gruss Lipper Biophotonics Center, Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA julio.aguirre-ghiso@einsteinmed.edu chodosh@pennmedicine.upenn.edu.

Lewis A Chodosh (LA)

Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA julio.aguirre-ghiso@einsteinmed.edu chodosh@pennmedicine.upenn.edu.
Department of Medicine, Abramson Cancer Center, and 2-PREVENT Translational Center of Excellence, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dormancy in Breast Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dormancy in Breast Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dormancy in Breast Cancer.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Dormancy in Breast Cancer.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Dormancy in Breast Cancer.