Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239.
Alzheimer’s disease
Amyloid beta
Aspergillus
BACE1
Fungus
Naphto-γ-pyrone
Polyketide
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
06
01
2023
accepted:
17
03
2023
medline:
31
5
2023
pubmed:
11
4
2023
entrez:
10
4
2023
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is an important human disease that mainly causes cognitive impairments. Growing evidence has shown that amyloid-β (Aβ) peptide plays a key role in AD pathogenesis in what is known as the Aβ cascade hypothesis. This hypothesis suggests the importance of suppressing Aβ aggregation and Aβ production. The latter process is governed by β-site APP Cleaving Enzyme1 (BACE1) and γ-secretase. We, therefore, focused on Aβ aggregation inhibitory activity, initially assessing numerous extracts derived from our marine-derived fungus collections. One EtOAc extract derived from an Aspergillus sp. exhibited Aβ aggregation inhibitory activity. Eleven known compounds (1-11) were isolated from CHCl
Identifiants
pubmed: 37038034
doi: 10.1007/s11418-023-01696-9
pii: 10.1007/s11418-023-01696-9
pmc: PMC10088752
doi:
Substances chimiques
Amyloid Precursor Protein Secretases
EC 3.4.-
Pyrones
0
Aspartic Acid Endopeptidases
EC 3.4.23.-
Amyloid beta-Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
516-522Subventions
Organisme : JSPS KAKENHI Grants-in-Aid for Scientific Research (C)
ID : JP 17K08351
Organisme : JSPS KAKENHI Grants-in-Aid for Scientific Research (C)
ID : JP 19K07143
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.
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