Neonatal exposure to hypoxia induces early arterial stiffening via activation of lysyl oxidases.
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
02
03
2023
received:
28
11
2022
accepted:
03
03
2023
medline:
12
4
2023
entrez:
11
4
2023
pubmed:
12
4
2023
Statut:
ppublish
Résumé
Hypoxia in the neonatal period is associated with early manifestations of adverse cardiovascular health in adulthood including higher risk of hypertension and atherosclerosis. We hypothesize that this occurs due to activation of lysyl oxidases (LOXs) and the remodeling of the large conduit vessels, leading to early arterial stiffening. Newborn C57Bl/6 mice were exposed to hypoxia (FiO
Identifiants
pubmed: 37038896
doi: 10.14814/phy2.15656
pmc: PMC10086679
doi:
Substances chimiques
Protein-Lysine 6-Oxidase
EC 1.4.3.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15656Subventions
Organisme : NHLBI NIH HHS
ID : K08HL145132
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL148112
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS099461
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS110808
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS111230
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS125653
Pays : United States
Informations de copyright
© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
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