Advances and innovations in living donor liver transplant techniques, matching and surgical training: Meeting report from the living donor liver transplant consensus conference.

ABO Incompatible living donor liver transplantation living paired exchanges surgical training

Journal

Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240

Informations de publication

Date de publication:
07 2023
Historique:
revised: 27 02 2023
received: 28 12 2022
accepted: 05 03 2023
medline: 14 7 2023
pubmed: 12 4 2023
entrez: 11 4 2023
Statut: ppublish

Résumé

The practice of LDLT currently delivers limited impact in western transplant centers. The American Society of Transplantation organized a virtual consensus conference in October 2021 to identify barriers and gaps to LDLT growth, and to provide evidence-based recommendations to foster safe expansion of LDLT in the United States. This article reports the findings and recommendations regarding innovations and advances in approaches to donor-recipient matching challenges, the technical aspects of the donor and recipient operations, and surgical training. Among these themes, the barriers deemed most influential/detrimental to LDLT expansion in the United States included: (1) prohibitive issues related to donor age, graft size, insufficient donor remnant, and ABO incompatibility; (2) lack of acknowledgment and awareness of the excellent outcomes and benefits of LDLT; (3) ambiguous messaging regarding LDLT to patients and hospital leadership; and (4) a limited number of proficient LDLT surgeons across the United States. Donor-recipient mismatching may be circumvented by way of liver paired exchange. The creation of a national registry to generate granular data on donor-recipient matching will guide the practice of liver paired exchange. The surgical challenges to LDLT are addressed herein and focuses on the development of robust training pathways resulting in proficiency in donor and recipient surgery. Utilizing strong mentorship/collaboration programs with novel training practices under the auspices of established training and certification bodies will add to the breadth and depth of training.

Identifiants

pubmed: 37039541
doi: 10.1111/ctr.14968
doi:

Types de publication

Consensus Development Conference Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14968

Informations de copyright

© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Références

Barbetta A, Aljehani M, Kim M, et al. Meta-analysis and meta-regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation. Am J Transplant. 2021;21:2399-2412.
Barbetta A, Butler C, Barhouma S, et al. Living donor versus deceased donor pediatric liver transplantation: a systematic review and meta-analysis. Transplant Direct. 2021;7:e767.
Humar A, Ganesh S, Jorgensen D, et al. Adult living donor versus deceased donor liver transplant (LDLT versus DDLT) at a single center: time to change our paradigm for liver transplant. Ann Surg. 2019;270:444-451.
Trotter JF, Adam R, Lo CM, Kenison J. Documented deaths of hepatic lobe donors for living donor liver transplantation. Liver Transpl. 2006;12:1485-1488.
Kwong AJ, Ebel NH, Kim WR, et al. OPTN/SRTR 2020 annual data report: liver. Am J Transplant. 2022;22(2):204-309.
Marsh JW, Gray E, Ness R, Starzl TE. Complications of right lobe living donor liver transplantation. J Hepatol. 2009;51:715-724.
Tran L, Humar A. Expanding living donor liver transplantation in the Western world: changing the paradigm. Dig Med Res. 2020;3:52.
Trotter JF, Wisniewski KA, Terrault NA, et al. Outcomes of donor evaluation in adult-to-adult living donor liver transplantation. Hepatology. 2007;46:1476-1484.
Hwang S, Lee SG, Moon DB, et al. Exchange living donor liver transplantation to overcome ABO incompatibility in adult patients. Liver Transpl. 2010;16:482-490.
Oh J, Kim JM. Immunologic strategies and outcomes in ABO-incompatible living donor liver transplantation. Clin Mol Hepatol. 2020;26:1-6.
Pamecha V, Mahansaria SS, Bharathy KG, et al. Selection and outcome of the potential live liver donor. Hepatol Int. 2016;10:657-664.
Al-Hamoudi W, Abaalkhail F, Bendahmash A, et al. The impact of metabolic syndrome and prevalent liver disease on living donor liver transplantation: a pressing need to expand the pool. Hepatol Int. 2016;10:347-354.
Sharma A, Ashworth A, Behnke M, Cotterell A, Posner M, Fisher RA. Donor selection for adult-to-adult living donor liver transplantation: well begun is half done. Transplantation. 2013;95:501-506.
Abecassis MM, Fisher RA, Olthoff KM, et al. Complications of living donor hepatic lobectomy-a comprehensive report. Am J Transplant. 2012;12:1208-1217.
Miller CM, Durand F, Heimbach JK, et al. The international liver transplant society guideline on living liver donation. Transplantation. 2016;100:1238-1243.
Miller C, Florman S, Kim-Schluger L, et al. Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor. Liver Transpl. 2004;10:1315-1319.
Olthoff KM, Smith AR, Abecassis M, et al. Defining long-term outcomes with living donor liver transplantation in North America. Ann Surg. 2015;262:465-475. discussion 473-465.
Liapakis A, Jesse MT, Pillai A et al. Living donor liver transplantation: a multi-disciplinary collaboration towards growth and consensus, and a change in culture. Clin Transplant. 2023;8:e14953. doi: 10.1111/ctr.14953. Epub ahead of print.
Yoshizumi T, Taketomi A, Uchiyama H, et al. Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation. Liver Transpl. 2008;14:1007-1013.
Goldberg DS, French B, Abt PL, Olthoff K, Shaked A. Superior survival using living donors and donor-recipient matching using a novel living donor risk index. Hepatology. 2014;60:1717-1726.
Ikegami T, Yoshizumi T, Sakata K, et al. Left lobe living donor liver transplantation in adults: what is the safety limit. Liver Transpl. 2016;22:1666-1675.
Halazun KJ, Przybyszewski EM, Griesemer AD, et al. Leaning to the left: increasing the donor pool by using the left lobe, outcomes of the largest single-center North American experience of left lobe adult-to-adult living donor liver transplantation. Ann Surg. 2016;264:448-456.
Pomposelli JJ, Goodrich NP, Emond JC, et al. Patterns of early allograft dysfunction in adult live donor liver transplantation: the A2ALL Experience. Transplantation. 2016;100:1490-1499.
Soin AS, Pahari H, Pomfret EA. A worldwide survey of live liver donor selection policies at 24 centers with a combined experience of 19 009 adult living donor liver transplants. Transplantation. 2019:;103:e39-e47.
Goldaracena N, Sapisochin G, Spetzler V, et al. Live donor liver transplantation with older (>/= 50 years) versus younger (<50 years) donors: does age matter. Ann Surg. 2016;263:979-985.
Kadohisa M, Inomata Y, Uto K, et al. Impact of donor age on the outcome of living-donor liver transplantation: special consideration to the feasibility of using elderly donors. Transplantation. 2021;105:328-337.
Tanemura A, Mizuno S, Kato H, et al. D-MELD, the product of donor age and preoperative MELD, predicts surgical outcomes after living donor liver transplantation, especially in the recipients with HCV-positive and smaller grafts. Transplant Proc. 2016;48:1025-1031.
Soin AS, Goja S, Yadav SK, et al. D+10) MELD as a novel predictor of patient and graft survival after adult to adult living donor liver transplantation. Clin Transplant. 2017;31:e12939.
Egawa H, Teramukai S, Haga H, et al. Impact of rituximab desensitization on blood-type-incompatible adult living donor liver transplantation: a Japanese multicenter study. Am J Transplant. 2014;14:102-114.
Kim JM, Kwon CH, Joh JW, et al. ABO-incompatible living donor liver transplantation is suitable in patients without ABO-matched donor. J Hepatol. 2013;59:1215-1222.
Musat AI, Agni RM, Wai PY, et al. The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation. Am J Transplant. 2011;11:500-510.
Castillo-Rama M, Sebagh M, Sasatomi E, et al. “Plasma cell hepatitis” in liver allografts: identification and characterization of an IgG4-rich cohort. Am J Transplant. 2013;13:2966-2977.
O'Leary JG, Demetris AJ, Friedman LS, et al. The role of donor-specific HLA alloantibodies in liver transplantation. Am J Transplant. 2014;14:779-787.
Legaz I, Boix F, Lopez M, et al. Influence of preformed antibodies in liver transplantation. J Clin Med. 2020;9(3):708.
Tamura K, Tohyama T, Watanabe J, et al. Preformed donor-specific antibodies are associated with 90-day mortality in living-donor liver transplantation. Hepatol Res. 2019;49:929-941.
den Dulk AC, Shi X, Verhoeven CJ, et al. Donor-specific anti-HLA antibodies are not associated with nonanastomotic biliary strictures but both are independent risk factors for graft loss after liver transplantation. Clin Transplant. 2018:32(2):e13163.
Braun HJ, Torres AM, Louie F, et al. Expanding living donor liver transplantation: report of first US living donor liver transplant chain. Am J Transplant. 2021;21:1633-1636.
Broering DC, Berardi G, El Sheikh Y, Spagnoli A, Troisi RI. Learning curve under proctorship of pure laparoscopic living donor left lateral sectionectomy for pediatric transplantation. Ann Surg. 2020;271:542-548.
Broering D, Sturdevant ML, Zidan A. Robotic donor hepatectomy: a major breakthrough in living donor liver transplantation. Am J Transplant. 2022;22:14-23.
Liu W, Wang K, Xiao YL, Liu C, Gao W, Li DH. Clinical relevance of donor-specific human leukocyte antigen antibodies after pediatric liver transplantation. Exp Ther Med. 2021;22:867.
Del Bello A, Congy-Jolivet N, Danjoux M, et al. De novo donor-specific anti-HLA antibodies mediated rejection in liver-transplant patients. Transpl Int. 2015;28:1371-1382.
Grabhorn E, Binder TM, Obrecht D, et al. Long-term clinical relevance of de novo donor-specific antibodies after pediatric liver transplantation. Transplantation. 2015;99:1876-1881.
Levitsky J, Kaneku H, Jie C, Walsh RC, Abecassis M, Tambur AR. Donor-specific HLA antibodies in living versus deceased donor liver transplant recipients. Am J Transplant. 2016;16:2437-2444.
Mishra A, Lo A, Lee GS, et al. Liver paired exchange: can the liver emulate the kidney. Liver Transpl. 2018;24:677-686.
Jung DH, Hwang S, Ahn CS, et al. Section 16. Update on experience in paired-exchange donors in living donor liver transplantation for adult patients at ASAN Medical Center. Transplantation. 2014;97(Suppl 8):S66-S69.
Samstein B, Cherqui D, Rotellar F, et al. Totally laparoscopic full left hepatectomy for living donor liver transplantation in adolescents and adults. Am J Transplant. 2013;13:2462-2466.
Samstein B, Griesemer A, Cherqui D, et al. Fully laparoscopic left-sided donor hepatectomy is safe and associated with shorter hospital stay and earlier return to work: a comparative study. Liver Transpl. 2015;21:768-773.
Sturdevant M, Zidan A, Broering D. Robotic donor hepatectomy: a niche advancement or the way forward? A perspective from the world's largest center. Hepatoma Res. 2022;8(1)2394-5079. doi:10.20517/2394-5079.2021.111
Sturdevant ML, Zidan A, Broering D. Minimally-invasive donor hepatectomy at the dawn of a decade: can we pick up the pace. Dig Med Res. 2020;3:58..
Barbas AS, Goldaracena N, Dib MJ, et al. Early intervention with live donor liver transplantation reduces resource utilization in NASH: the Toronto experience. Transplant Direct. 2017;3:e158.

Auteurs

Mark Sturdevant (M)

University of Washington Medical Center, Seattle, Washington, USA.

Swaytha Ganesh (S)

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Benjamin Samstein (B)

Weill Cornell Medicine, New York, New York, USA.

Elizabeth C Verna (EC)

Center for Liver Disease and Transplantation, Columbia University, New York City, New York, USA.

Manuel Rodriguez-Davalos (M)

Intermountain Healthcare, Salt Lake City, Utah, USA.

Vineeta Kumar (V)

Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Marwan Abouljoud (M)

Henry Ford Transplant Institute, Detroit, Michigan, USA.

Oya Andacoglu (O)

University of Oklahoma, Oklahoma, Oklahoma, USA.

Medhat Askar (M)

Baylor University Medical Center, Dallas, Texas, USA.

Dieter Broering (D)

King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Juliet Emamaullee (J)

University of Southern California, Los Angeles, California, USA.

Jean C Emond (JC)

Center for Liver Disease and Transplantation, Columbia University, New York City, New York, USA.

Christine E Haugen (CE)

Center for Liver Disease and Transplantation, Columbia University, New York City, New York, USA.

Michelle T Jesse (MT)

Henry Ford Transplant Institute, Detroit, Michigan, USA.

Mureo Kasahara (M)

National Center for Child Health and Development, Tokyo, Japan.

AnnMarie Liapakis (A)

Yale School of Medicine and Yale New Haven Transplant Center, New Haven, Connecticut, USA.

Didier Mandelbrot (D)

Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.

Anjana Pillai (A)

University of Chicago Medicine, Chicago, Illinois, USA.

Garrett R Roll (GR)

Department of Surgery, University of California San Francisco, San Francisco, California, USA.

Nazia Selzner (N)

Ajmera Transplant Center, University of Toronto, Toronto, Canada.

Sukru Emre (S)

University School of Medicine, Izmir, Turkey.

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