Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis.
Cardiac sodium channel
Microtubules
Plus-end tracking proteins
Regulation
Subcellular
Journal
Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427
Informations de publication
Date de publication:
04 07 2023
04 07 2023
Historique:
received:
10
10
2022
revised:
12
12
2022
accepted:
20
12
2022
medline:
5
7
2023
pubmed:
12
4
2023
entrez:
11
4
2023
Statut:
ppublish
Résumé
The cardiac sodium channel NaV1.5 is an essential modulator of cardiac excitability, with decreased NaV1.5 levels at the plasma membrane and consequent reduction in sodium current (INa) leading to potentially lethal cardiac arrhythmias. NaV1.5 is distributed in a specific pattern at the plasma membrane of cardiomyocytes, with localization at the crests, grooves, and T-tubules of the lateral membrane and particularly high levels at the intercalated disc region. NaV1.5 forms a large macromolecular complex with and is regulated by interacting proteins, some of which are specifically localized at either the lateral membrane or intercalated disc. One of the NaV1.5 trafficking routes is via microtubules (MTs), which are regulated by MT plus-end tracking proteins (+TIPs). In our search for mechanisms involved in targeted delivery of NaV1.5, we here provide an overview of previously demonstrated interactions between NaV1.5 interacting proteins and +TIPs, which potentially (in)directly impact on NaV1.5 trafficking. Strikingly, +TIPs interact extensively with several intercalated disc- and lateral membrane-specific NaV1.5 interacting proteins. Recent work indicates that this interplay of +TIPs and NaV1.5 interacting proteins mediates the targeted delivery of NaV1.5 at specific cardiomyocyte subcellular domains, while also being potentially relevant for the trafficking of other ion channels. These observations are especially relevant for diseases associated with loss of NaV1.5 specifically at the lateral membrane (such as Duchenne muscular dystrophy), or at the intercalated disc (for example, arrhythmogenic cardiomyopathy), and open up potential avenues for development of new anti-arrhythmic therapies.
Identifiants
pubmed: 37040608
pii: 7115247
doi: 10.1093/cvr/cvad052
pmc: PMC10318397
doi:
Substances chimiques
NAV1.5 Voltage-Gated Sodium Channel
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1461-1479Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
Déclaration de conflit d'intérêts
Conflict of interest: The authors report no conflict of interest to declare.
Références
J Cell Biol. 1995 Jul;130(1):67-77
pubmed: 7790378
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H667-76
pubmed: 18552167
Mol Biol Cell. 2005 Nov;16(11):5334-45
pubmed: 16148041
Dev Cell. 2004 Dec;7(6):871-83
pubmed: 15572129
PLoS One. 2014 Sep 22;9(9):e107535
pubmed: 25244344
Cardiovasc Res. 2012 Sep 1;95(4):409-18
pubmed: 22764152
Traffic. 2014 Jun;15(6):684-99
pubmed: 24612377
Circulation. 2012 Oct 23;126(17):2084-94
pubmed: 23008441
Neuron. 2000 Apr;26(1):13-25
pubmed: 10798388
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8826-31
pubmed: 21551097
Sci Rep. 2017 Nov 14;7(1):15533
pubmed: 29138501
Biochim Biophys Acta. 2013 Apr;1833(4):886-94
pubmed: 23123192
Circulation. 2006 Apr 4;113(13):1650-8
pubmed: 16567567
Cell. 2015 Oct 22;163(3):712-23
pubmed: 26496610
Nat Cell Biol. 2009 Sep;11(9):1069-80
pubmed: 19701196
Circ Res. 2006 Aug 18;99(4):407-14
pubmed: 16857961
J Biol Chem. 2003 Sep 19;278(38):36430-4
pubmed: 12857735
Int J Mol Sci. 2018 Oct 23;19(11):
pubmed: 30360568
Circ Res. 2014 Nov 7;115(11):929-38
pubmed: 25239140
Trends Neurosci. 2018 Sep;41(9):555-556
pubmed: 30143179
Cold Spring Harb Perspect Biol. 2015 Sep 09;8(3):a020495
pubmed: 26354894
Cell Physiol Biochem. 2020 Mar 17;54(2):252-270
pubmed: 32176842
Physiol Rev. 2012 Jul;92(3):1317-58
pubmed: 22811429
J Neurosci. 2012 Oct 17;32(42):14722-8
pubmed: 23077057
Genomics. 2001 Jan 15;71(2):142-9
pubmed: 11161807
FASEB J. 2019 Aug;33(8):9434-9452
pubmed: 31112396
Circ Res. 2002 Mar 8;90(4):443-9
pubmed: 11884374
J Biol Chem. 2013 Nov 8;288(45):32302-32313
pubmed: 24072717
Cell. 2008 Oct 3;135(1):137-48
pubmed: 18854161
Science. 2015 Mar 27;347(6229):1441-1446
pubmed: 25814576
Mol Cell Neurosci. 2005 Apr;28(4):599-612
pubmed: 15797708
J Cell Sci. 2013 Sep 1;126(Pt 17):4000-14
pubmed: 23813963
Biochim Biophys Acta. 2015 Jun;1850(6):1215-23
pubmed: 25721215
J Cell Biol. 2009 Jul 27;186(2):219-28
pubmed: 19620634
Eur J Cell Biol. 2009 Feb;88(2):91-102
pubmed: 19004523
Circ Res. 2017 Sep 15;121(7):784-802
pubmed: 28912183
Exp Cell Res. 2010 Feb 1;316(3):297-313
pubmed: 19932097
J Cell Biol. 1994 Dec;127(6 Pt 2):2061-9
pubmed: 7806582
Mol Cell Biol. 2007 Dec;27(23):8215-27
pubmed: 17923693
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10687-E10696
pubmed: 29162697
PLoS One. 2010 Mar 01;5(3):e9465
pubmed: 20209123
Cardiovasc Res. 2020 Jul 15;116(9):1571-1584
pubmed: 32246823
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):554-8
pubmed: 1309946
Front Cell Neurosci. 2015 Jun 30;9:241
pubmed: 26175669
Channels (Austin). 2016 Sep 2;10(5):410-420
pubmed: 27246624
J Biol Chem. 2014 Jun 13;289(24):17043-53
pubmed: 24782306
Heart Rhythm. 2011 Dec;8(12):1923-30
pubmed: 21767519
J Cell Biol. 2007 Jun 4;177(5):857-70
pubmed: 17548513
Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1357-H1370
pubmed: 32196358
J Cell Biol. 2017 Oct 2;216(10):3179-3198
pubmed: 28814570
J Biol Chem. 2004 Sep 24;279(39):40748-54
pubmed: 15272007
JCI Insight. 2016 Apr 21;1(5):
pubmed: 27170944
J Am Coll Cardiol. 2014 Feb 18;63(6):549-59
pubmed: 24291282
Nature. 1995 Aug 24;376(6542):683-5
pubmed: 7651517
Circ Res. 2011 Sep 16;109(7):775-82
pubmed: 21817159
Neuron. 2012 Apr 26;74(2):331-43
pubmed: 22542186
Biochem Biophys Res Commun. 2009 Nov 6;389(1):172-6
pubmed: 19715666
J Mol Cell Cardiol. 2015 Dec;89(Pt B):287-96
pubmed: 26493106
J Cell Biol. 1992 Aug;118(3):671-9
pubmed: 1639850
Circ Res. 2004 Aug 6;95(3):284-91
pubmed: 15217910
Biochem J. 2014 Nov 1;463(3):339-49
pubmed: 25088759
Circ Res. 2009 Sep 11;105(6):523-6
pubmed: 19661460
J Mol Cell Cardiol. 2013 Aug;61:133-141
pubmed: 23702286
Exp Biol Med (Maywood). 2019 Nov;244(15):1255-1272
pubmed: 31398994
J Biol Chem. 2016 Sep 23;291(39):20692-706
pubmed: 27451391
PLoS Biol. 2010 Feb 16;8(2):e1000312
pubmed: 20169111
Biochim Biophys Acta Mol Basis Dis. 2020 Nov 1;1866(11):165915
pubmed: 32768677
J Biol Chem. 2010 Jul 16;285(29):22658-65
pubmed: 20466722
Circulation. 2014 Jul 8;130(2):147-60
pubmed: 24895455
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17533-8
pubmed: 15579534
Cell Commun Adhes. 2014 Jun;21(3):169-79
pubmed: 24766605
J Physiol. 2013 Sep 1;591(17):4099-116
pubmed: 23818691
J Cell Sci. 2009 Aug 15;122(Pt 16):2969-79
pubmed: 19638411
Cardiovasc Res. 2017 Mar 1;113(3):259-275
pubmed: 28069669
Nat Cell Biol. 2002 Apr;4(4):323-7
pubmed: 11912492
Mol Biol Cell. 2001 Apr;12(4):795-808
pubmed: 11294887
Cardiovasc Res. 2019 May 1;115(6):1078-1091
pubmed: 30329023
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12413-8
pubmed: 9356463
Hum Mol Genet. 2005 Mar 1;14(5):667-77
pubmed: 15661756
J Biol Chem. 2003 Jan 10;278(2):1029-36
pubmed: 12401812
Oncogene. 2000 Apr 6;19(15):1950-8
pubmed: 10773885
Sci Rep. 2018 May 15;8(1):7546
pubmed: 29765066
J Cell Biol. 2010 Aug 9;190(3):443-60
pubmed: 20696710
J Cell Sci. 2003 Dec 1;116(Pt 23):4847-56
pubmed: 14600269
J Biol Chem. 2008 Mar 14;283(11):6968-78
pubmed: 18184654
Dev Cell. 2014 Jan 27;28(2):117-31
pubmed: 24412576
Cell. 2020 Jan 9;180(1):122-134.e10
pubmed: 31866066
Trends Cardiovasc Med. 2008 Apr;18(3):78-87
pubmed: 18436145
J Cell Sci. 2007 Jun 15;120(Pt 12):2126-36
pubmed: 17535849
Heart Rhythm. 2012 Apr;9(4):600-7
pubmed: 22100711
Cell. 2007 Feb 9;128(3):547-60
pubmed: 17289573
Cell. 2010 Apr 2;141(1):117-28
pubmed: 20371349
Curr Biol. 2014 Aug 4;24(15):1778-85
pubmed: 25065758
Front Physiol. 2018 Mar 12;9:178
pubmed: 29593552
J Cell Biol. 2011 Aug 22;194(4):631-42
pubmed: 21844209
J Neurosci. 2012 Oct 3;32(40):13906-16
pubmed: 23035100
Nat Cell Biol. 2010 Jun;12(6):583-90
pubmed: 20495555
Mol Biol Cell. 2009 Aug;20(16):3660-70
pubmed: 19553473
Circ Res. 2011 Jul 8;109(2):193-201
pubmed: 21617128
Circulation. 2001 Mar 6;103(9):1303-10
pubmed: 11238277
PLoS One. 2013 Sep 26;8(9):e73887
pubmed: 24086300
EMBO J. 2001 Nov 15;20(22):6203-12
pubmed: 11707392
J Cell Sci. 2006 Jul 1;119(Pt 13):2758-67
pubmed: 16772339
J Neurosci. 2013 Nov 6;33(45):17884-96
pubmed: 24198377
Curr Biol. 2012 Oct 9;22(19):1800-7
pubmed: 22885064
Nat Cell Biol. 2005 May;7(5):474-82
pubmed: 15834408
J Cell Sci. 2019 Oct 9;132(19):
pubmed: 31597743
Biol Open. 2013 Feb 15;2(2):238-50
pubmed: 23430395
J Cell Biol. 2013 Oct 28;203(2):205-13
pubmed: 24145165
J Cell Biol. 2015 Aug 31;210(5):737-51
pubmed: 26323690
Cardiovasc Res. 2020 Jul 15;116(9):1557-1570
pubmed: 32251506
J Cell Sci. 2013 Jun 1;126(Pt 11):2319-29
pubmed: 23729742
Proc Natl Acad Sci U S A. 2019 May 28;116(22):10763-10772
pubmed: 31072926
PLoS Biol. 2013 Jul;11(7):e1001611
pubmed: 23874158
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12528-33
pubmed: 26392562
J Mol Cell Cardiol. 2016 Apr;93:32-43
pubmed: 26902968
Cell. 2015 Apr 23;161(3):647-660
pubmed: 25910212
Circ Res. 2006 Jun 23;98(12):1538-46
pubmed: 16728661
Cardiovasc Res. 2010 Mar 1;85(4):691-700
pubmed: 19861310
Hum Mol Genet. 2018 Jun 15;27(12):2090-2100
pubmed: 29618008
Cell. 2008 Dec 26;135(7):1189-200
pubmed: 19109891
Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1502-9
pubmed: 26209461
Circ Res. 2021 Jul 23;129(3):349-365
pubmed: 34092082
Curr Biol. 2010 Jun 22;20(12):R528-37
pubmed: 20620909
EMBO Rep. 2009 Aug;10(8):857-65
pubmed: 19543227
Am J Physiol Cell Physiol. 2005 Mar;288(3):C692-701
pubmed: 15548568
Nat Cell Biol. 2001 Oct;3(10):913-7
pubmed: 11584273
Front Physiol. 2017 Nov 14;8:903
pubmed: 29184507
J Biol Chem. 2004 Jul 30;279(31):32046-54
pubmed: 15161933
Heart Rhythm. 2012 Jul;9(7):1133-1140.e6
pubmed: 22406144
Heart Rhythm. 2011 May;8(5):711-8
pubmed: 21220045
J Mol Cell Cardiol. 2001 Apr;33(4):599-613
pubmed: 11273715
EMBO Rep. 2021 Jan 7;22(1):e50949
pubmed: 33251722
J Biol Chem. 2002 Mar 22;277(12):10512-22
pubmed: 11790773
J Physiol. 2009 Oct 1;587(Pt 19):4565-74
pubmed: 19675065
Arch Biochem Biophys. 1999 May 15;365(2):216-22
pubmed: 10328815
Elife. 2018 Aug 14;7:
pubmed: 30106376
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2134-43
pubmed: 22509027
Nat Cell Biol. 2008 Jan;10(1):19-29
pubmed: 18066053
Front Physiol. 2020 Dec 17;11:609733
pubmed: 33391024
J Cell Biol. 2014 Sep 15;206(6):779-97
pubmed: 25225338
Mol Biol Cell. 2018 May 15;29(10):1168-1177
pubmed: 29540526
Mol Cell Biol. 2014 Sep 15;34(18):3546-58
pubmed: 25022754
FEBS Lett. 2002 Feb 20;513(1):119-23
pubmed: 11911890
J Biol Chem. 2006 Jan 6;281(1):365-73
pubmed: 16257958
J Cell Biol. 2019 Jan 7;218(1):299-316
pubmed: 30463880
J Biol Chem. 1995 Aug 25;270(34):20201-6
pubmed: 7650039
Mol Biol Cell. 2017 Sep 1;28(18):2400-2409
pubmed: 28701340
Dis Model Mech. 2012 Jul;5(4):468-80
pubmed: 22563055
EMBO Mol Med. 2017 Mar;9(3):319-336
pubmed: 28069640
J Cell Biol. 2002 Nov 25;159(4):589-99
pubmed: 12446741
J Cell Sci. 2014 Feb 15;127(Pt 4):727-39
pubmed: 24338362
Curr Biol. 2008 Feb 12;18(3):177-82
pubmed: 18249114
Nat Rev Cardiol. 2014 Feb;11(2):96-111
pubmed: 24322550
Circ Arrhythm Electrophysiol. 2019 Nov;12(11):e007382
pubmed: 31726860
Biochem Biophys Res Commun. 2009 Oct 16;388(2):290-6
pubmed: 19664597
J Biol Chem. 2018 Nov 23;293(47):18207-18217
pubmed: 30282806
J Biol Chem. 2009 Nov 13;284(46):31992-2001
pubmed: 19759393
J Cell Biol. 2005 Jan 3;168(1):141-53
pubmed: 15631994
Biochemistry. 2001 Dec 11;40(49):14898-906
pubmed: 11732910
Cardiovasc Res. 2017 Jan;113(1):102-111
pubmed: 28069705
Elife. 2020 Jan 14;9:
pubmed: 31934859
J Cell Biol. 1997 Jul 14;138(1):193-201
pubmed: 9214392
Int J Mol Sci. 2018 May 24;19(6):
pubmed: 29882937
J Mol Cell Cardiol. 2010 Jan;48(1):2-11
pubmed: 19744495
Cold Spring Harb Perspect Biol. 2016 Oct 3;8(10):
pubmed: 27698030
Circ Res. 2018 May 25;122(11):1501-1516
pubmed: 29514831
PLoS One. 2013 May 01;8(5):e62165
pubmed: 23658710
J Cell Biol. 2002 Jul 22;158(2):305-19
pubmed: 12119357
Nat Genet. 2022 Mar;54(3):232-239
pubmed: 35210625
Eur J Heart Fail. 2007 Mar;9(3):219-27
pubmed: 17067855
Cardiovasc Res. 2003 Nov 1;60(2):376-87
pubmed: 14613867
Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1446-52
pubmed: 19666841
Eur Heart J. 2007 Mar;28(5):581-8
pubmed: 17105751
Neuron. 2006 Dec 7;52(5):803-16
pubmed: 17145502
Dev Cell. 2021 Jul 26;56(14):2016-2028.e4
pubmed: 34022132
J Cell Biol. 2008 Jan 14;180(1):173-86
pubmed: 18180363
Genes Dev. 2011 Sep 15;25(18):1968-81
pubmed: 21937714
Circ Arrhythm Electrophysiol. 2020 Jul;13(7):e008241
pubmed: 32536203
J Cell Biol. 2005 Sep 12;170(6):895-901
pubmed: 16157700
Circ Res. 2016 Aug 5;119(4):544-56
pubmed: 27364017
Biochem Biophys Res Commun. 2006 Oct 6;348(4):1455-62
pubmed: 16930557
J Cell Biol. 2009 Mar 9;184(5):691-706
pubmed: 19255245
J Cell Biol. 2011 Jun 13;193(6):1083-99
pubmed: 21646404
Cardiovasc Res. 2017 Oct 1;113(12):1521-1531
pubmed: 28957532
Card Electrophysiol Clin. 2014 Dec 1;6(4):797-809
pubmed: 25395996
J Cell Biol. 2013 Dec 23;203(6):1043-61
pubmed: 24368809
ACS Chem Neurosci. 2015 Apr 15;6(4):615-31
pubmed: 25650780
Cell. 2002 Jun 28;109(7):873-85
pubmed: 12110184
J Biol Chem. 2019 Nov 1;294(44):16123-16140
pubmed: 31511323
Sci Rep. 2016 May 06;6:25372
pubmed: 27150728
Cell. 2003 Oct 31;115(3):343-54
pubmed: 14636561
Trends Biochem Sci. 2020 May;45(5):440-453
pubmed: 32311337
Curr Opin Neurobiol. 2014 Aug;27:96-102
pubmed: 24705243
J Mol Biol. 2011 Feb 11;406(1):106-19
pubmed: 21167176
J Cell Sci. 2008 Oct 15;121(Pt 20):3413-21
pubmed: 18827011
J Clin Invest. 2010 Jan;120(1):266-79
pubmed: 20038810
J Cell Biol. 2021 Dec 6;220(12):
pubmed: 34705028
Nat Commun. 2016 Mar 31;7:11117
pubmed: 27030108
J Cell Sci. 2000 May;113 ( Pt 10):1737-45
pubmed: 10769205
J Cell Biol. 2008 Dec 29;183(7):1223-33
pubmed: 19103809
Circulation. 2004 Mar 23;109(11):1421-7
pubmed: 15007009
Circ Arrhythm Electrophysiol. 2012 Oct;5(5):1017-26
pubmed: 22929165
J Biol Chem. 2011 Jun 10;286(23):20478-89
pubmed: 21507952
J Clin Invest. 2010 Oct;120(10):3508-19
pubmed: 20877009
J Clin Invest. 2013 Jan;123(1):75-83
pubmed: 23281413
Genes Dev. 2013 Nov 15;27(22):2473-88
pubmed: 24240237
J Cell Biol. 2011 Dec 26;195(7):1185-203
pubmed: 22184201
Curr Biol. 1999 Apr 22;9(8):425-8
pubmed: 10226031
Channels (Austin). 2014;8(1):20-8
pubmed: 24366036
Nature. 2017 May 25;545(7655):505-509
pubmed: 28514442
J Cell Sci. 2020 Apr 24;133(8):
pubmed: 32332092
J Biol Chem. 2008 Jun 13;283(24):16537-44
pubmed: 18408010
J Neurosci. 2016 Apr 20;36(16):4421-33
pubmed: 27098687
Circ Res. 2011 Feb 4;108(3):294-304
pubmed: 21164104
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5723-8
pubmed: 24706788
Cells. 2020 Jun 03;9(6):
pubmed: 32503326
Nat Commun. 2016 Jan 20;7:10342
pubmed: 26787348
Circ Cardiovasc Genet. 2012 Aug 1;5(4):400-11
pubmed: 22781308
Biochemistry. 2010 Jan 12;49(1):166-78
pubmed: 19943616
EMBO J. 1996 Jun 17;15(12):2997-3005
pubmed: 8670801
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81
pubmed: 25691752
Cell Mol Life Sci. 2016 May;73(10):2053-77
pubmed: 26969328
J Cell Sci. 2014 Nov 15;127(Pt 22):4904-17
pubmed: 25217626
Cardiovasc Res. 2014 Nov 1;104(2):371-81
pubmed: 25139742
J Cell Sci. 2000 Jun;113 ( Pt 12):2285-97
pubmed: 10825300
Circulation. 2014 Mar 11;129(10):1092-103
pubmed: 24352520
Circ Arrhythm Electrophysiol. 2018 Jan;11(1):e005800
pubmed: 29326130
Int J Mol Sci. 2021 Mar 26;22(7):
pubmed: 33810249
Curr Cardiol Rep. 2015 Jul;17(7):606
pubmed: 26026997
J Biol Chem. 1999 Jun 25;274(26):18597-604
pubmed: 10373470
Circ Res. 2007 Sep 28;101(7):703-11
pubmed: 17673670