Positive selection in cytochrome P450 genes is associated with gonad phenotype and mating strategy in social bees.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 04 2023
11 04 2023
Historique:
received:
04
10
2022
accepted:
04
04
2023
medline:
13
4
2023
entrez:
11
4
2023
pubmed:
12
4
2023
Statut:
epublish
Résumé
The honey bee, Apis mellifera differs from all other social bees in its gonad phenotype and mating strategy. Honey bee queens and drones have tremendously enlarged gonads, and virgin queens mate with several males. In contrast, in all the other bees, the male and female gonads are small, and the females mate with only one or very few males, thus, suggesting an evolutionary and developmental link between gonad phenotype and mating strategy. RNA-seq comparisons of A. mellifera larval gonads revealed 870 genes as differentially expressed in queens versus workers and drones. Based on Gene Ontology enrichment we selected 45 genes for comparing the expression levels of their orthologs in the larval gonads of the bumble bee Bombus terrestris and the stingless bee, Melipona quadrifasciata, which revealed 24 genes as differentially represented. An evolutionary analysis of their orthologs in 13 solitary and social bee genomes revealed four genes with evidence of positive selection. Two of these encode cytochrome P450 proteins, and their gene trees indicated a lineage-specific evolution in the genus Apis, indicating that cytochrome P450 genes may be involved in the evolutionary association of polyandry and the exaggerated gonad phenotype in social bees.
Identifiants
pubmed: 37041178
doi: 10.1038/s41598-023-32898-6
pii: 10.1038/s41598-023-32898-6
pmc: PMC10090045
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5921Informations de copyright
© 2023. The Author(s).
Références
Bioinformatics. 2012 Aug 15;28(16):2184-5
pubmed: 22743226
J Insect Physiol. 2000 Nov 1;46(11):1433-1439
pubmed: 10891571
Science. 2015 Jun 5;348(6239):1139-43
pubmed: 25977371
BMC Ecol Evol. 2021 Oct 20;21(1):189
pubmed: 34670487
Genome Biol Evol. 2021 Dec 1;13(12):
pubmed: 34850870
Curr Top Dev Biol. 1998;40:45-77
pubmed: 9673848
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Nucleic Acids Res. 2022 Jan 7;50(D1):D1032-D1039
pubmed: 34747465
Protein Eng. 2003 Aug;16(8):577-87
pubmed: 12968075
Genetics. 2009 Oct;183(2):693-707, 1SI-13SI
pubmed: 19620393
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18172-7
pubmed: 17079492
BMC Evol Biol. 2013 Jul 03;13:138
pubmed: 23822725
Bioinformatics. 2014 Nov 15;30(22):3276-8
pubmed: 25095880
Nucleic Acids Res. 2016 Jan 4;44(D1):D793-800
pubmed: 26578564
Ecol Evol. 2012 Dec;2(12):3098-109
pubmed: 23301175
G3 (Bethesda). 2017 Feb 9;7(2):467-479
pubmed: 27974438
PLoS One. 2014 Jan 08;9(1):e84879
pubmed: 24416303
J Insect Physiol. 2017 Aug;101:185-194
pubmed: 28800885
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5731-6
pubmed: 19289821
BMC Genomics. 2014 Jan 30;15:86
pubmed: 24479613
Sci Rep. 2017 Sep 12;7(1):11338
pubmed: 28900129
Curr Opin Insect Sci. 2015 Aug;10:51-58
pubmed: 29588014
Science. 2008 May 30;320(5880):1213-6
pubmed: 18511689
Chem Res Toxicol. 1997 Feb;10(2):156-64
pubmed: 9049426
Horm Behav. 2020 Nov;126:104844
pubmed: 32860832
Annu Rev Entomol. 2016;61:297-316
pubmed: 26667274
Annu Rev Entomol. 2005;50:395-420
pubmed: 15822204
Mol Biol Evol. 2015 May;32(5):1365-71
pubmed: 25701167
Annu Rev Entomol. 2006;51:581-608
pubmed: 16332224
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
J Evol Biol. 2011 Sep;24(9):1939-48
pubmed: 21696476
Mol Biol Evol. 2018 Sep 1;35(9):2097-2109
pubmed: 29924339
Sci Rep. 2019 Jun 4;9(1):8159
pubmed: 31164662
Genome Biol. 2015 Apr 24;16:76
pubmed: 25908251
Evolution. 2012 Dec;66(12):3778-88
pubmed: 23206136
Mol Genet Genomics. 2001 Dec;266(4):556-63
pubmed: 11810226
Nat Methods. 2008 Jul;5(7):621-8
pubmed: 18516045
Mol Biol Evol. 2016 Mar;33(3):670-8
pubmed: 26576851
BMC Genomics. 2019 Dec 30;20(1):1029
pubmed: 31888487
PLoS Genet. 2008 Dec;4(12):e1000304
pubmed: 19081788
J Chem Ecol. 2010 Nov;36(11):1241-3
pubmed: 20882325
Insect Mol Biol. 2022 Oct;31(5):593-608
pubmed: 35524973
Mol Biol Evol. 2016 Jul;33(7):1870-4
pubmed: 27004904
Insect Mol Biol. 2006 Oct;15(5):615-36
pubmed: 17069637
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2538-2543
pubmed: 28193870
Mol Phylogenet Evol. 2019 Jan;130:121-131
pubmed: 30326287