Fighting polymicrobial biofilms in bacterial vaginosis.
Journal
Microbial biotechnology
ISSN: 1751-7915
Titre abrégé: Microb Biotechnol
Pays: United States
ID NLM: 101316335
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
23
03
2023
received:
29
12
2022
accepted:
25
03
2023
medline:
22
6
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
Bacterial vaginosis (BV) is the most common cause of vaginal discharge and is often associated with other health consequences mainly in pregnant women. BV is described by an imbalance in the vaginal microbiota where strictly and facultative anaerobic bacteria outgrow the lactic acid- and hydrogen peroxide-producing Lactobacillus species. The species involved in BV are capable to grow and form a polymicrobial biofilm in the vaginal epithelium. The treatment of BV is usually performed using broad-spectrum antibiotics, including metronidazole and clindamycin. However, these conventional treatments are associated with high recurrence rates. The BV polymicrobial biofilm may have an important role on the treatment outcome and is accounted as one of the factors for treatment failure. Other possible reasons for treatment failure include the presence of species resistant to antibiotics or the chance of reinfection after treatment. Therefore, novel strategies to increase the rates of treatment have been studied namely the use of probiotics and prebiotics, acidifying agents, antiseptics, plant-based products, vaginal microbiota transplantation, and phage endolysins. Although some of them are still in an initial phase of development with very preliminary results, they show great perspectives for application. In this review, we aimed to study the role of the polymicrobial nature of BV in treatment failure and explore a few alternatives for treatment.
Identifiants
pubmed: 37042412
doi: 10.1111/1751-7915.14261
pmc: PMC10281382
doi:
Substances chimiques
Metronidazole
140QMO216E
Anti-Bacterial Agents
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1423-1437Informations de copyright
© 2023 The Authors. Microbial Biotechnology published by Applied Microbiology International and John Wiley & Sons Ltd.
Références
N Engl J Med. 2005 Nov 3;353(18):1899-911
pubmed: 16267321
Infect Immun. 2014 Nov;82(11):4718-28
pubmed: 25156721
Microb Biotechnol. 2022 Feb;15(2):590-602
pubmed: 34156757
Clin Infect Dis. 2013 Mar;56(6):777-86
pubmed: 23243173
Health Technol Assess. 2022 Jan;26(2):1-170
pubmed: 35057905
J Obstet Gynaecol. 2022 Jan;42(1):103-109
pubmed: 33629634
Int J Clin Pract. 2022 Apr 21;2022:4774783
pubmed: 35685517
Gynecol Obstet Invest. 2012;73(1):8-15
pubmed: 22205034
Microb Biotechnol. 2023 Jul;16(7):1423-1437
pubmed: 37042412
Nat Med. 2019 Oct;25(10):1500-1504
pubmed: 31591599
BMC Genomics. 2014 Dec 05;15:1070
pubmed: 25480015
J Adv Pharm Technol Res. 2018 Jan-Mar;9(1):15-19
pubmed: 29441319
Benef Microbes. 2019 Apr 19;10(4):385-393
pubmed: 30882242
Sex Transm Dis. 2009 Nov;36(11):732-4
pubmed: 19704395
Res Microbiol. 2017 Nov - Dec;168(9-10):865-874
pubmed: 28232119
mBio. 2021 Oct 26;12(5):e0232321
pubmed: 34663095
Clin Infect Dis. 2007 Jan 15;44(2):220-1
pubmed: 17173220
Expert Opin Pharmacother. 2021 Aug;22(12):1593-1600
pubmed: 33750246
ISME J. 2019 May;13(5):1306-1317
pubmed: 30670827
Int J Womens Health. 2011;3:295-305
pubmed: 21976983
Arzneimittelforschung. 2010;60(11):675-81
pubmed: 21175040
J Infect Dis. 2006 Jun 1;193(11):1478-86
pubmed: 16652274
Front Med (Lausanne). 2022 Feb 25;9:817957
pubmed: 35280911
Future Microbiol. 2019 Mar;14:365-368
pubmed: 30854891
Antimicrob Agents Chemother. 2022 May 17;66(5):e0231921
pubmed: 35416708
J Infect Dis. 2010 Dec 15;202(12):1907-15
pubmed: 21067371
Sci Rep. 2022 Mar 15;12(1):4417
pubmed: 35292704
Clin Infect Dis. 2007 Jan 15;44(2):213-9
pubmed: 17173219
Antibiotics (Basel). 2023 Feb 04;12(2):
pubmed: 36830238
Biochem Cell Biol. 2017 Feb;95(1):31-33
pubmed: 28140620
Clin Infect Dis. 2019 Feb 15;68(5):803-809
pubmed: 30184181
Ther Clin Risk Manag. 2009 Jun;5(3):485-9
pubmed: 19707258
Crit Rev Microbiol. 2017 Nov;43(6):651-667
pubmed: 28358585
BMC Infect Dis. 2019 Sep 18;19(1):824
pubmed: 31533663
Front Med (Lausanne). 2018 Jun 13;5:181
pubmed: 29951482
Pathog Dis. 2014 Apr;70(3):280-8
pubmed: 24391058
Curr Opin Infect Dis. 2020 Feb;33(1):59-65
pubmed: 31789672
Int J Med Microbiol. 2015 Dec;305(8):815-27
pubmed: 26372530
Front Cell Infect Microbiol. 2020 Mar 04;10:83
pubmed: 32195197
J Antimicrob Chemother. 2022 Jul 28;77(8):2183-2190
pubmed: 35578895
Antibiotics (Basel). 2021 Aug 13;10(8):
pubmed: 34439028
Viruses. 2018 Jun 07;10(6):
pubmed: 29875339
Anaerobe. 2015 Dec;36:56-9
pubmed: 26505928
J Clin Microbiol. 1991 Feb;29(2):297-301
pubmed: 1706728
Front Cell Infect Microbiol. 2019 Aug 28;9:306
pubmed: 31555606
Sex Transm Dis. 2010 Dec;37(12):745-50
pubmed: 20644497
Microbiome. 2021 Dec 10;9(1):239
pubmed: 34893070
Res Microbiol. 2017 Nov - Dec;168(9-10):859-864
pubmed: 28257809
Avicenna J Phytomed. 2017 Mar-Apr;7(2):129-136
pubmed: 28348968
Pathogens. 2021 Jan 08;10(1):
pubmed: 33435575
PeerJ. 2019 May 15;7:e6884
pubmed: 31143534
BMC Infect Dis. 2011 Jul 19;11:200
pubmed: 21771337
Microbiome. 2017 Sep 13;5(1):119
pubmed: 28903767
Microbiology (Reading). 2010 Feb;156(Pt 2):392-399
pubmed: 19910411
Anaerobe. 2021 Jun;69:102343
pubmed: 33582302
J Infect Dis. 2016 Aug 15;214 Suppl 1:S14-20
pubmed: 27449869
Front Cell Infect Microbiol. 2022 May 04;12:824860
pubmed: 35601098
Front Microbiol. 2022 Sep 08;13:1000822
pubmed: 36419418
Appl Environ Microbiol. 2018 Feb 14;84(5):
pubmed: 29269494
Int J Womens Health. 2010 Aug 09;1:59-65
pubmed: 21072275
BMC Infect Dis. 2006 Mar 16;6:51
pubmed: 16542416
PLoS One. 2017 Feb 27;12(2):e0172522
pubmed: 28241058
Sex Transm Dis. 2007 Nov;34(11):864-9
pubmed: 17621244
J Infect Dis. 2006 Sep 15;194(6):828-36
pubmed: 16941351
PLoS One. 2018 Jan 2;13(1):e0190199
pubmed: 29293559
Antibiotics (Basel). 2021 Oct 20;10(11):
pubmed: 34827215
Am J Obstet Gynecol. 2011 Mar;204(3):211.e1-6
pubmed: 21167471
FEMS Microbiol Lett. 2010 Mar;304(1):29-38
pubmed: 20082639
J Med Life. 2021 Mar-Apr;14(2):250-256
pubmed: 34104249
Lancet. 1991 Feb 2;337(8736):300
pubmed: 1671134
Sex Transm Dis. 2021 Oct 1;48(10):761-765
pubmed: 34110746
MMWR Recomm Rep. 2021 Jul 23;70(4):1-187
pubmed: 34292926
Am J Obstet Gynecol. 2013 Dec;209(6):505-23
pubmed: 23659989
BMC Med. 2021 Sep 2;19(1):194
pubmed: 34470644
ISRN Obstet Gynecol. 2012;2012:183403
pubmed: 23209922
Front Microbiol. 2020 Nov 06;11:594065
pubmed: 33240248
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4680-7
pubmed: 20534435
Microb Biotechnol. 2020 Mar;13(2):423-434
pubmed: 31448542
Front Cell Infect Microbiol. 2020 Feb 28;10:71
pubmed: 32257961
Pathogens. 2021 Jan 20;10(2):
pubmed: 33498226
Am J Obstet Gynecol. 2001 Nov;185(5):1186-90
pubmed: 11717655
Future Microbiol. 2018 Sep;13:1215-1223
pubmed: 30238774
Front Microbiol. 2022 Jan 04;12:757327
pubmed: 35058893
J Law Med Ethics. 2019 Dec;47(4):555-567
pubmed: 31957577
Sex Transm Dis. 1992 May-Jun;19(3):146-8
pubmed: 1523530
Curr Med Chem. 2013;20(23):2914-28
pubmed: 23651308
J Matern Fetal Neonatal Med. 2012 Jul;25(7):1021-4
pubmed: 21854132
J Obstet Gynaecol. 2022 Aug;42(6):2105-2114
pubmed: 35166152
Am J Obstet Gynecol. 2004 Oct;191(4):1124-9
pubmed: 15507930
Biotechnol Adv. 2022 May-Jun;56:107915
pubmed: 35101567
J Clin Diagn Res. 2016 Mar;10(3):QC04-7
pubmed: 27134945
J Infect Dis. 1997 Feb;175(2):406-13
pubmed: 9203662
Nat Rev Microbiol. 2016 Aug 11;14(9):563-75
pubmed: 27510863
Front Cell Infect Microbiol. 2020 Aug 11;10:354
pubmed: 32850469
BMC Infect Dis. 2013 Oct 16;13:480
pubmed: 24131550
J Low Genit Tract Dis. 2022 Jan 1;26(1):79-84
pubmed: 34928257
Arch Gynecol Obstet. 2022 Oct 17;:
pubmed: 36251068
Skin Pharmacol Physiol. 2012;25(6):298-304
pubmed: 22907313
Arch Gynecol Obstet. 2014 Mar;289(3):479-89
pubmed: 24170161
J Midwifery Womens Health. 2019 Sep;64(5):578-591
pubmed: 31368667
Antibiotics (Basel). 2022 Apr 09;11(4):
pubmed: 35453251
J Infect Dis. 2019 Aug 30;220(7):1099-1108
pubmed: 30715405
Diagn Microbiol Infect Dis. 2016 Jan;84(1):1-3
pubmed: 26514076
Microb Biotechnol. 2017 Sep;10(5):1054-1056
pubmed: 28696066
Dermatology. 2002;204 Suppl 1:79-85
pubmed: 12011527
Eur J Obstet Gynecol Reprod Biol. 2020 Feb;245:143-148
pubmed: 31901667
3 Biotech. 2021 Apr;11(4):169
pubmed: 33816046
Arch Gynecol Obstet. 2016 Mar;293(3):469-84
pubmed: 26506926
Antibiotics (Basel). 2021 Jun 15;10(6):
pubmed: 34203908
Front Cell Infect Microbiol. 2021 Feb 19;11:568178
pubmed: 33680986
Obstet Gynecol. 2005 Nov;106(5 Pt 1):1013-23
pubmed: 16260520
Eur J Obstet Gynecol Reprod Biol. 2008 Dec;141(2):158-62
pubmed: 18775597
Pathogens. 2021 Feb 20;10(2):
pubmed: 33672647
Environ Microbiol. 2013 Oct;15(10):2865-78
pubmed: 23751003
PLoS One. 2013;8(1):e53997
pubmed: 23320114
PLoS One. 2012;7(4):e34540
pubmed: 22509319
Arch Gynecol Obstet. 2010 Jul;282(1):43-7
pubmed: 19809829
Clin Infect Dis. 2008 Jul 1;47(1):33-43
pubmed: 18513147
Front Microbiol. 2018 Aug 22;9:2007
pubmed: 30186281
Microb Pathog. 2019 Feb;127:21-30
pubmed: 30502515
PLoS One. 2013 Sep 11;8(9):e74378
pubmed: 24040236
J Infect Dis. 2019 Sep 26;220(9):1399-1405
pubmed: 31369673
Sex Transm Infect. 2016 Nov;92(7):487-491
pubmed: 26965870
Antibiotics (Basel). 2022 Apr 22;11(5):
pubmed: 35625202
Am J Med. 1983 Jan;74(1):14-22
pubmed: 6600371
J Infect Dis. 2018 Aug 14;218(6):966-978
pubmed: 29718358
Sci Rep. 2015 Jun 26;5:11640
pubmed: 26113465
J Clin Microbiol. 2007 Oct;45(10):3270-6
pubmed: 17687006
Arch Gynecol Obstet. 2018 Jan;297(1):109-116
pubmed: 28983665
Sex Transm Dis. 2019 May;46(5):304-311
pubmed: 30624309
PLoS One. 2021 Feb 11;16(2):e0246953
pubmed: 33571286
Sex Transm Dis. 2020 May;47(5):344-346
pubmed: 32149953
J Infect Dis. 2015 Dec 15;212(12):1856-61
pubmed: 26080369
Can J Infect Dis Med Microbiol. 2020 Jun 16;2020:1361825
pubmed: 32612729
FEMS Microbiol Rev. 2020 Jan 1;44(1):73-105
pubmed: 31697363
Pathogens. 2021 Feb 25;10(3):
pubmed: 33668706
Am J Obstet Gynecol. 2008 Jan;198(1):97.e1-6
pubmed: 18005928
J Low Genit Tract Dis. 2022 Jan 1;26(1):99-104
pubmed: 34928260
Planta Med. 2011 Dec;77(18):1996-2002
pubmed: 21830186
Front Cell Infect Microbiol. 2022 May 27;12:905739
pubmed: 35719334
BJOG. 2021 Mar;128(4):756-767
pubmed: 33480468
J Infect Dis. 2014 Aug 15;210(4):593-6
pubmed: 24596283
J Obstet Gynaecol Res. 2006 Apr;32(2):243-51
pubmed: 16594932
Antibiotics (Basel). 2020 Feb 03;9(2):
pubmed: 32028684
Sci Rep. 2022 Oct 26;12(1):17948
pubmed: 36289360
Front Cell Infect Microbiol. 2021 Apr 07;11:631972
pubmed: 33898328
Arch Gynecol Obstet. 2015 Mar;291(3):605-9
pubmed: 25245669
Microbiome. 2013 Dec 02;1(1):29
pubmed: 24451163
Sex Transm Dis. 2019 Dec;46(12):810-812
pubmed: 31663976
J Infect Dev Ctries. 2016 Sep 30;10(9):913-919
pubmed: 27694723