Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization.
Mendelian randomization
genetics
genomics
head and neck cancer
human
metabolic traits
obesity
oral cancer
oropharyngeal cancer
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 04 2023
12 04 2023
Historique:
received:
12
08
2022
accepted:
11
04
2023
medline:
1
5
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
epublish
Résumé
A recent World Health Organization report states that at least 40% of all cancer cases may be preventable, with smoking, alcohol consumption, and obesity identified as three of the most important modifiable lifestyle factors. Given the significant decline in smoking rates, particularly within developed countries, other potentially modifiable risk factors for head and neck cancer warrant investigation. Obesity and related metabolic disorders such as type 2 diabetes (T2D) and hypertension have been associated with head and neck cancer risk in multiple observational studies. However, adiposity has also been correlated with smoking, with bias, confounding or reverse causality possibly explaining these findings. To overcome the challenges of observational studies, we conducted two-sample Mendelian randomization (inverse variance weighted [IVW] method) using genetic variants which were robustly associated with adiposity, glycaemic and blood pressure traits in genome-wide association studies (GWAS). Outcome data were taken from the largest available GWAS of 6034 oral and oropharyngeal cases, with 6585 controls. We found limited evidence of a causal effect of genetically proxied body mass index (BMI; OR IVW = 0.89, 95% CI 0.72-1.09, p = 0.26 per 1 standard deviation in BMI [4.81kg/m
Identifiants
pubmed: 37042641
doi: 10.7554/eLife.82674
pii: 82674
pmc: PMC10147379
doi:
pii:
Banques de données
dbGaP
['phs001202.v1.p1', 'phs000585.v2.p1']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/7
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : R01 DE025712
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Informations de copyright
© 2023, Gormley et al.
Déclaration de conflit d'intérêts
MG, TD, ST, JT, AN, MP, DL, GD, RR, EV, CB No competing interests declared
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