Paraglottic Space Invasion in Glottic Laryngeal Cancer: A Clinical-Pathological Study.
CT scan
endoscopy
glottis
head and neck neoplasms
imaging
laryngeal neoplasms
laryngectomy
laryngoscopy
squamous cell carcinoma of head and neck
x-ray
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
18
07
2022
received:
11
03
2022
accepted:
25
07
2022
medline:
14
4
2023
entrez:
12
4
2023
pubmed:
13
4
2023
Statut:
ppublish
Résumé
This study aims to prospectively compare endoscopic, radiological, and pathological features of a cohort of patients with glottic laryngeal squamous cell carcinoma (LSCC) undergoing open partial horizontal laryngectomy (OPHL) type II/III or total laryngectomy to better understand the reliability of preoperative endoscopy and computed tomography (CT) to predict the inferior paraglottic space (iPGS) involvement. We prospectively compared the endoscopic, radiological, and pathological findings in patients with glottic LSCC who underwent OPHL II/III, or total laryngectomy. Endoscopy achieved a diagnostic accuracy of 87.2% for the anterior iPGS (iPGSa) and 86.1% for the posterior iPGS (iPGSp). There was no statistically significant difference in terms of histopathologic iPGSa involvement between reduced (85%-17/20 pts) and absent (92%-24/26 pts) vocal cord mobility (p = 0.39). CT alone did not improve the diagnostic performance of the endoscopy, reaching a diagnostic accuracy of 62.9% and 73.7% for the iPGSa and iPGSp, respectively. When endoscopy and CT were combined, the diagnostic performance improved for the iPGSp, achieving a sensitivity (Se), specificity (Spe), positive predictive value (PPV), and negative predictive value (NPV) of 100%, 89.8%, 68.7%, and 100%, respectively. On the contrary, the combination of CT and endoscopy improved only the Se and NPV for the iPGSa with respect to the sole endoscopic assessment. Whenever motility impairment is present, a histopathologic invasion of the iPGS should be suspected. Endoscopic assessment of laryngeal motility achieved a satisfactory value of Se, Spe, PPV, and NPV in predicting the involvement of the iPGS. CT scan is still the mainstay imaging technique in the clinical staging of patients with LSCC. 4 Laryngoscope, 133:1184-1190, 2023.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1184-1190Informations de copyright
© 2022 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.
Références
Tucker GF, Smith HR. A histological demonstration of the development of laryngeal connective tissue compartments. Trans Am Acad Ophthalmol Otolaryngol. 1962;66:308-318.
Succo G, Crosetti E, Bertolin A, et al. Treatment for T3 to T4a laryngeal cancer by open partial horizontal laryngectomies: prognostic impact of different pathologic tumor subcategories. Head Neck. 2018;40(9):1897-1908. https://doi.org/10.1002/hed.25176.
Ravanelli M, Paderno A, Del Bon F, et al. Prediction of posterior paraglottic space and cricoarytenoid unit involvement in endoscopically T3 glottic cancer with arytenoid fixation by magnetic resonance with surface coils. Cancer. 2019;11(1):67. https://doi.org/10.3390/cancers11010067.
Amin MB, Edge SB, Greene FL, et al. AJCC Cancer Staging Manual. 8th ed. Springer-Verlag; 2017.
Succo G, Peretti G, Piazza C, et al. Open partial horizontal laryngectomies: a proposal for classification by the working committee on nomenclature of the European Laryngological Society. Eur Arch Otorhinolaryngol. 2014;271(9):2489-2496.
Peretti G, Piazza C, Cocco D, et al. Transoral CO2 laser treatment for Tis-T3 glottic cancer: the University of Brescia experience on 595 patients. Head Neck. 2009;32(8):977-983. https://doi.org/10.1002/hed.21278.
Remacle M, Eckel HE, Antonelli A, et al. Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society. Eur Arch Otorhinolaryngol. 2000;257(4):227-231. https://doi.org/10.1007/s004050050228.
Dagan R, Morris CG, Bennett JA, et al. Prognostic significance of paraglottic space invasion in T2N0 glottic carcinoma. Am J Clin Oncol. 2007;30(2):186-190. https://doi.org/10.1097/01.coc.0000251403.54180.df.
Murakami R, Nishimura R, Baba Y, et al. Prognostic factors of glottic carcinomas treated with radiation therapy: value of the adjacent sign on radiological examinations in the sixth edition of the UICC TNM staging system. Int J Radiat Oncol Biol Phys. 2005;61(2):471-475. https://doi.org/10.1016/j.ijrobp.2004.05.024.
Katilmiş H, Oztürkcan S, Ozdemir I, et al. A clinico-pathological study of laryngeal and hypopharyngeal carcinoma: correlation of cord-arytenoid mobility with histopathologic involvement. Otolaryngol Head Neck Surg. 2007;136(2):291-295. https://doi.org/10.1016/j.otohns.2006.08.022.
Becker M, Monnier Y, de Vito C. MR imaging of laryngeal and hypopharyngeal cancer. Magn Reson Imaging Clin N Am. 2022;30(1):53-72. https://doi.org/10.1016/j.mric.2021.08.002.
Zbären P, Nuyens M, Curschmann J, Stauffer E. Histologic characteristics and tumor spread of recurrent glottic carcinoma: analysis on whole-organ sections and comparison with tumor spread of primary glottic carcinomas. Head Neck. 2007;29(1):26-32. https://doi.org/10.1002/hed.20502.
Rosen CA, Mau T, Remacle M, et al. Nomenclature proposal to describe vocal fold motion impairment. Eur Arch Otorhinolaryngol. 2016;273(8):1995-1999. https://doi.org/10.1007/s00405-015-3663-0.
Helliwell T, Chernock R, Dahlstrom JE, et al. Data set for the reporting of carcinomas of the hypopharynx, larynx, and trachea: explanations and recommendations of the guidelines from the international collaboration on cancer reporting. Arch Pathol Lab Med. 2019;143(4):432-438. https://doi.org/10.5858/arpa.2018-0419-SA.
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159-174. https://doi.org/10.2307/2529310.
Bertrand M, Tollard E, François A, et al. CT scan, MR imaging and anatomopathologic correlation in the glottic carcinoma T1-T2. Rev Laryngol Otol Rhinol. 2010;131(1):51-57.
Maroldi R, Ravanelli M, Farina D. Magnetic resonance for laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2014;22(2):131-139. https://doi.org/10.1097/MOO.0000000000000036.
Lucioni M, Lionello M, Machin P, et al. Sclerosis of the arytenoid cartilage and glottic carcinoma: a clinical-pathological study. Head Neck. 2018;41(1):72-78. https://doi.org/10.1002/hed.25372.
Benazzo M, Sovardi F, Preda L, et al. Imaging accuracy in preoperative staging of T3-T4 laryngeal cancers. Cancer. 2020;12(5):1074. https://doi.org/10.3390/cancers12051074.
Jaipuria B, Dosemane D, Kamath PM, Sreedharan SS, Shenoy VS. Staging of laryngeal and hypopharyngeal cancer: computed tomography versus histopathology. Iran J Otorhinolaryngol. 2018;30(99):189-194.
Mattioli F, Fermi M, Molinari G, et al. pT3 N0 laryngeal squamous cell carcinoma: oncologic outcomes and prognostic factors of surgically treated patients. Laryngoscope. 2021;131(10):2262-2268. https://doi.org/10.1002/lary.29528.
Peretti G, Piazza C, Mora F, Garofolo S, Guastini L. Reasonable limits for transoral laser microsurgery in laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2016;24(2):135-139. https://doi.org/10.1097/MOO.0000000000000240.
Adamian N, Naunheim MR, Jowett N. An open-source computer vision tool for automated vocal fold tracking from videoendoscopy. Laryngoscope. 2021;131(1):E219-E225. https://doi.org/10.1002/lary.28669.