Nonylphenol Exposure-Induced Oocyte Quality Deterioration Could be Reversed by Boric Acid Supplementation in Rats.
Animals
Female
Rats
Dietary Supplements
Oocytes
/ drug effects
Oxidative Stress
/ drug effects
Sirtuin 1
/ genetics
Superoxide Dismutase
/ metabolism
Boric Acids
/ pharmacology
Phenols
/ toxicity
Environmental Exposure
/ prevention & control
Gene Expression Regulation
/ drug effects
TOR Serine-Threonine Kinases
/ genetics
Boric acid
DNA damage
Nonylphenol
oxidative stress
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
03
03
2023
accepted:
31
03
2023
medline:
18
7
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
In this study, we reported boric acid's protective effects on the quality of nonylphenol (NP)-exposed oocytes. Female rats were classified into 4 groups: control, boric acid, NP, and NP+boric acid. Histopathological studies and immunohistochemical analysis of anti-müllerian hormone (AMH), mechanistic target of rapamycin (mTOR), Sirtuin1 (SIRT1), stem cell factor (SCF) studies were done. The comet assay technique was utilized for DNA damage. The ELISA method was used to determine the concentrations of oxidative stress indicators (SOD, CAT, and MDA), ovarian hormone (INH-B), and inflammation indicators (IL-6 and TNF-α). Boric acid significantly reduced the histopathological alterations and nearly preserved the ovarian reserve. With the restoration of AMH and SCF, boric acid significantly improved the ovarian injury. It downregulated SIRT1 and upregulated the mTOR signaling pathway. It provided DNA damage protection. Ovarian SOD, CAT levels were decreased by boric acid. Boric acid co-administration significantly reduced NP's MDA, IL-6, and TNF-activities. This results imply that boric acid has a protective role in ovarian tissue against NP-mediated infertility.
Identifiants
pubmed: 37043110
doi: 10.1007/s12011-023-03657-5
pii: 10.1007/s12011-023-03657-5
doi:
Substances chimiques
boric acid
R57ZHV85D4
nonylphenol
79F6A2ILP5
Sirtuin 1
EC 3.5.1.-
Superoxide Dismutase
EC 1.15.1.1
Boric Acids
0
Phenols
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4518-4529Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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