Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination.
3C-like protease inhibitors
COVID-19
Crystal structure
Peptidomimetics
Reversible covalent inhibitors
SARS-CoV-2
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 May 2023
05 May 2023
Historique:
received:
13
12
2022
revised:
23
03
2023
accepted:
26
03
2023
medline:
25
4
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
Despite the approval of vaccines, monoclonal antibodies and restrictions during the pandemic, the demand for new efficacious and safe antivirals is compelling to boost the therapeutic arsenal against the COVID-19. The viral 3-chymotrypsin-like protease (3CL
Identifiants
pubmed: 37043904
pii: S0223-5234(23)00277-5
doi: 10.1016/j.ejmech.2023.115311
pmc: PMC10068823
pii:
doi:
Substances chimiques
Protease Inhibitors
0
Peptidomimetics
0
Peptide Hydrolases
EC 3.4.-
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115311Informations de copyright
Copyright © 2023 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
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