Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction.

Mice Animals Docosahexaenoic Acids / pharmacology Fatty Acids, Omega-3 / pharmacology Eicosapentaenoic Acid / pharmacology Diet Inflammation / metabolism Psoriasis / drug therapy Fatty Acids / metabolism
DHA EPA Psoriasis inflammation lipid mediators polyunsaturated fatty acids

Journal

The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081

Informations de publication

Date de publication:
07 2023
Historique:
received: 15 09 2022
revised: 27 03 2023
accepted: 03 04 2023
medline: 22 5 2023
pubmed: 13 4 2023
entrez: 12 4 2023
Statut: ppublish

Résumé

Persistent skin inflammation and impaired resolution are the main contributors to psoriasis and associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are known to exert beneficial effects on inflammatory response and lipid function. However, a specific role of omega-3 PUFAs in psoriasis and accompanied pathologies are still a matter of debate. Here, we carried out a direct comparison between EPA and DHA 12 weeks diet intervention treatment of psoriasis-like skin inflammation in the K14-Rac1V12 mouse model. By utilizing sensitive techniques, we targeted EPA- and DHA-derived specialized pro-resolving lipid mediators and identified tightly connected signaling pathways by RNA sequencing. Treatment with experimental diets significantly decreased circulating pro-inflammatory cytokines and bioactive lipid mediators, altered psoriasis macrophage phenotypes and genes of lipid oxidation. The superficial role of these changes was related to DHA treatment and included increased levels of resolvin D5, protectin DX and maresin 2 in the skin. EPA treated mice had less pronounced effects but demonstrated a decreased skin accumulation of prostaglandin E

Identifiants

DOI: 10.1016/j.jnutbio.2023.109348 PMID: 37044136
pubmed: 37044136
pii: S0955-2863(23)00081-5
doi: 10.1016/j.jnutbio.2023.109348
pii:
doi:

Substances chimiques

Docosahexaenoic Acids 25167-62-8
Fatty Acids, Omega-3 0
Eicosapentaenoic Acid AAN7QOV9EA
Fatty Acids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109348

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Alexander V Sorokin (AV)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: sorokinav2@nhlbi.nih.gov.

Hildur Arnardottir (H)

Division of Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institute, Sweden.

Maryia Svirydava (M)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Qimin Ng (Q)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Yvonne Baumer (Y)

Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Alexander Berg (A)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Carla J Pantoja (CJ)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Elizabeth M Florida (EM)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Heather L Teague (HL)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Zhi-Hong Yang (ZH)

Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Pradeep K Dagur (PK)

Flow Cytometry Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Tiffany M Powell-Wiley (TM)

Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Zu-Xi Yu (ZX)

Pathology Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Martin P Playford (MP)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Alan T Remaley (AT)

Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Nehal N Mehta (NN)

Section of Inflammation and Cardiometabolic Diseases, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Eucaryotes › Animaux › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide docosahexaénoïque › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide eicosapentanoïque › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Comparison of the dietary omega-3 fatty acids...
questionsmedicales.fr › Lipides › Acides gras › Comparison of the dietary omega-3 fatty acids...