Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit.
Aging
Chaperone-mediated autophagy
Circadian clock
Neurodegeneration
Neurovascular unit
Oligodendrocyte precursor cells
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
05
02
2023
revised:
27
03
2023
accepted:
07
04
2023
medline:
17
5
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
The neurovascular unit is where two very distinct physiological systems meet: The central nervous system (CNS) and the blood. The permeability of the barriers separating these systems is regulated by time, including both the 24 h circadian clock and the longer processes of aging. An endogenous circadian rhythm regulates the transport of molecules across the blood-brain barrier and the circulation of the cerebrospinal fluid and the glymphatic system. These fluid dynamics change with time of day, and with age, and especially in the context of neurodegeneration. Factors may differ depending on brain region, as can be highlighted by consideration of circadian regulation of the neurovascular niche in white matter. As an example of a potential target for clinical applications, we highlight chaperone-mediated autophagy as one mechanism at the intersection of circadian dysregulation, aging and neurodegenerative disease. In this review we emphasize key areas for future research.
Identifiants
pubmed: 37044366
pii: S0969-9961(23)00134-1
doi: 10.1016/j.nbd.2023.106120
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106120Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM126545
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.