Ageing-associated changes in transcriptional elongation influence longevity.

Animals Humans Mice Rats Aging / genetics Insulin / metabolism Longevity / genetics RNA Polymerase II / genetics Signal Transduction Transcription Elongation, Genetic Drosophila melanogaster / genetics Caenorhabditis elegans / genetics RNA, Circular Somatomedins Nucleosomes Histones Cell Division Caloric Restriction

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 2023
Historique:
received: 10 09 2019
accepted: 07 03 2023
medline: 28 4 2023
pubmed: 13 4 2023
entrez: 12 4 2023
Statut: ppublish

Résumé

Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing

Identifiants

DOI: 10.1038/s41586-023-05922-y PMID: 37046086 PMC: PMC10132977
pubmed: 37046086
doi: 10.1038/s41586-023-05922-y
pii: 10.1038/s41586-023-05922-y
pmc: PMC10132977
doi:

Substances chimiques

Insulin 0
RNA Polymerase II EC 2.7.7.-
RNA, Circular 0
Somatomedins 0
Nucleosomes 0
Histones 0

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

814-821

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Cédric Debès (C)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Antonios Papadakis (A)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Sebastian Grönke (S)

Max Planck Institute for Biology of Ageing, Cologne, Germany.
ORCID: 0000-0002-1539-5346

Özlem Karalay (Ö)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Luke S Tain (LS)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Athanasia Mizi (A)

Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.

Shuhei Nakamura (S)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Oliver Hahn (O)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Max Planck Institute for Biology of Ageing, Cologne, Germany.

Carina Weigelt (C)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Natasa Josipovic (N)

Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Anne Zirkel (A)

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Isabell Brusius (I)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
ORCID: 0000-0003-2568-1351

Konstantinos Sofiadis (K)

Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Mantha Lamprousi (M)

Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.

Yu-Xuan Lu (YX)

Max Planck Institute for Biology of Ageing, Cologne, Germany.
ORCID: 0000-0001-6751-5250

Wenming Huang (W)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Reza Esmaillie (R)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Torsten Kubacki (T)

Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
ORCID: 0000-0001-7723-9659

Martin R Späth (MR)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
ORCID: 0000-0002-1624-0055

Bernhard Schermer (B)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
ORCID: 0000-0002-5194-9000

Thomas Benzing (T)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
ORCID: 0000-0003-0512-1066

Roman-Ulrich Müller (RU)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
ORCID: 0000-0001-6910-0745

Adam Antebi (A)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. aantebi@age.mpg.de.
Max Planck Institute for Biology of Ageing, Cologne, Germany. aantebi@age.mpg.de.
ORCID: 0000-0002-7241-3029

Linda Partridge (L)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. partridge@age.mpg.de.
Max Planck Institute for Biology of Ageing, Cologne, Germany. partridge@age.mpg.de.
Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, UCL, London, UK. partridge@age.mpg.de.
ORCID: 0000-0001-9615-0094

Argyris Papantonis (A)

Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany. argyris.papantonis@med.uni-goettingen.de.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. argyris.papantonis@med.uni-goettingen.de.
ORCID: 0000-0001-7551-1073

Andreas Beyer (A)

Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. andreas.beyer@uni-koeln.de.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. andreas.beyer@uni-koeln.de.
Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. andreas.beyer@uni-koeln.de.
ORCID: 0000-0002-3891-2123

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Élongation de la transcription › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN circulaire › Ageing-associated changes in transcriptional...
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questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Ageing-associated changes in transcriptional...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Ration calorique › Restriction calorique › Ageing-associated changes in transcriptional...