Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Animals
Humans
Mice
Adenocarcinoma of Lung
/ immunology
Carcinoma, Non-Small-Cell Lung
/ immunology
Disease Models, Animal
Endogenous Retroviruses
/ immunology
Immunotherapy
/ methods
Lung
/ immunology
Lung Neoplasms
/ immunology
Tumor Microenvironment
B-Lymphocytes
/ immunology
Cohort Studies
Antibodies
/ immunology
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
07
03
2022
accepted:
30
01
2023
medline:
21
4
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)
Identifiants
pubmed: 37046094
doi: 10.1038/s41586-023-05771-9
pii: 10.1038/s41586-023-05771-9
pmc: PMC10115647
doi:
Substances chimiques
Hras protein, mouse
EC 3.6.5.2
Cxcl13 protein, mouse
0
Antibodies
0
Banques de données
ClinicalTrials.gov
['NCT01888601']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
563-573Subventions
Organisme : Cancer Research UK
ID : CTRNBC-2022/100001
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V033077/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29911
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 21999
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 24956
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 17786
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29569
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 30025
Pays : United Kingdom
Investigateurs
Andrew Rowan
(A)
Ariana Huebner
(A)
Brittany B Campbell
(BB)
Chris Bailey
(C)
Claudia Lee
(C)
Dhruva Biswas
(D)
Emma Colliver
(E)
Foteini Athanasopoulou
(F)
Haoran Zhai
(H)
Jayant K Rane
(JK)
Kristiana Grigoriadis
(K)
Michelle Dietzen
(M)
Michelle Leung
(M)
Mihaela Angelova
(M)
Olivia Lucas
(O)
Othman Al-Sawaf
(O)
Rachel Rosenthal
(R)
Jerome Nicod
(J)
Abigail Bunkum
(A)
Antonia Toncheva
(A)
Christopher Abbosh
(C)
Corentin Richard
(C)
Cristina Naceur-Lombardelli
(C)
Francisco Gimeno-Valiente
(F)
Jie Min Lam
(JM)
Kerstin Thol
(K)
Krupa Thakkar
(K)
Mariana Werner Sunderland
(M)
Martin D Forster
(MD)
Nnennaya Kanu
(N)
Paulina Prymas
(P)
Robert Bentham
(R)
Sadegh Saghafinia
(S)
Sergio A Quezada
(SA)
Sharon Vanloo
(S)
Simone Zaccaria
(S)
Siow Ming Lee
(SM)
Sonya Hessey
(S)
Wing Kin Liu
(WK)
Dionysis Papadatos-Pastos
(D)
James Wilson
(J)
Sarah Benafif
(S)
Tanya Ahmad
(T)
Elaine Borg
(E)
Mary Falzon
(M)
Reena Khiroya
(R)
Teresa Marafioti
(T)
Abigail Sharp
(A)
Camilla Pilotti
(C)
Harjot Kaur Dhanda
(HK)
Kitty Chan
(K)
Nicole Gower
(N)
Rachel Leslie
(R)
Sean Smith
(S)
Andrew G Nicholson
(AG)
Eric Lim
(E)
Javier Herrero
(J)
Carla Castignani
(C)
Elizabeth Larose Cadieux
(E)
Jonas Demeulemeester
(J)
Peter Van Loo
(P)
Karl S Peggs
(KS)
Catarina Veiga
(C)
Gary Royle
(G)
Charles-Antoine Collins-Fekete
(CA)
Alexander James Procter
(AJ)
Arjun Nair
(A)
Asia Ahmed
(A)
Magali N Taylor
(MN)
Neal Navani
(N)
Ricky M Thakrar
(RM)
David Lawrence
(D)
Davide Patrini
(D)
Emma Nye
(E)
Richard Kevin Stone
(RK)
David Chuter
(D)
Mairead MacKenzie
(M)
Francesco Fraioli
(F)
Paul Ashford
(P)
Sam M Janes
(SM)
Miljana Tanić
(M)
Stephan Beck
(S)
Alexandra Rice
(A)
Anand Devaraj
(A)
Chiara Proli
(C)
Daniel Kaniu
(D)
Harshil Bhayani
(H)
Hema Chavan
(H)
Hilgardt Raubenheimer
(H)
Lyn Ambrose
(L)
Mpho Malima
(M)
Nadia Fernandes
(N)
Paulo De Sousa
(P)
Pratibha Shah
(P)
Sarah Booth
(S)
Silviu I Buderi
(SI)
Simon Jordan
(S)
Sofina Begum
(S)
Ekaterini Boleti
(E)
Aengus Stewart
(A)
Alastair Magness
(A)
Clare E Weeden
(CE)
Dina Levi
(D)
Eva Grönroos
(E)
Jacki Goldman
(J)
Mickael Escudero
(M)
Philip Hobson
(P)
Roberto Vendramin
(R)
Stefan Boeing
(S)
Tamara Denner
(T)
Vittorio Barbè
(V)
Wei-Ting Lu
(WT)
William Hill
(W)
Yutaka Naito
(Y)
Zoe Ramsden
(Z)
Anca Grapa
(A)
Hanyun Zhang
(H)
Khalid AbdulJabbar
(K)
Xiaoxi Pan
(X)
Kayleigh Gilbert
(K)
Angeliki Karamani
(A)
Benny Chain
(B)
David R Pearce
(DR)
Despoina Karagianni
(D)
Elena Hoxha
(E)
Felip Gálvez-Cancino
(F)
Georgia Stavrou
(G)
Gerasimos Mastrokalos
(G)
Helen L Lowe
(HL)
Ignacio Matos
(I)
James L Reading
(JL)
John A Hartley
(JA)
Kayalvizhi Selvaraju
(K)
Kezhong Chen
(K)
Leah Ensell
(L)
Mansi Shah
(M)
Marcos Vasquez
(M)
Maria Litovchenko
(M)
Olga Chervova
(O)
Piotr Pawlik
(P)
Robert E Hynds
(RE)
Saioa López
(S)
Samuel Gamble
(S)
Seng Kuong Anakin Ung
(SKA)
Supreet Kaur Bola
(SK)
Thanos P Mourikis
(TP)
Victoria Spanswick
(V)
Yin Wu
(Y)
Emilie Martinoni Hoogenboom
(E)
Fleur Monk
(F)
James W Holding
(JW)
Junaid Choudhary
(J)
Kunal Bhakhri
(K)
Marco Scarci
(M)
Martin Hayward
(M)
Nikolaos Panagiotopoulos
(N)
Pat Gorman
(P)
Robert C M Stephens
(RCM)
Steve Bandula
(S)
Yien Ning Sophia Wong
(YNS)
Tristan Clark
(T)
Heather Cheyne
(H)
Mohammed Khalil
(M)
Shirley Richardson
(S)
Tracey Cruickshank
(T)
Babu Naidu
(B)
Gurdeep Matharu
(G)
Jacqui A Shaw
(JA)
Joan Riley
(J)
Lindsay Primrose
(L)
John Le Quesne
(J)
Kevin G Blyth
(KG)
Alastair Kerr
(A)
Alexandra Clipson
(A)
Anshuman Chaturvedi
(A)
Caroline Dive
(C)
Dominic G Rothwell
(DG)
Elaine Kilgour
(E)
Jonathan Tugwood
(J)
Lynsey Priest
(L)
Pedro Oliveira
(P)
Philip Crosbie
(P)
Gillian Price
(G)
Judith Cave
(J)
Keith M Kerr
(KM)
Colin R Lindsay
(CR)
Fiona H Blackhall
(FH)
Matthew G Krebs
(MG)
Yvonne Summers
(Y)
Alan Kirk
(A)
Mathew Thomas
(M)
Mo Asif
(M)
Nikos Kostoulas
(N)
Rocco Bilancia
(R)
Gary Middleton
(G)
Michael J Shackcloth
(MJ)
Angela Leek
(A)
Jack Davies Hodgkinson
(JD)
Nicola Totten
(N)
Craig Dick
(C)
Lily Robinson
(L)
Peter Russell
(P)
Madeleine Hewish
(M)
Sarah Danson
(S)
Jason F Lester
(JF)
Fabio Gomes
(F)
Kate Brown
(K)
Mathew Carter
(M)
Akshay J Patel
(AJ)
Aya Osman
(A)
Christer Lacson
(C)
Gerald Langman
(G)
Helen Shackleford
(H)
Madava Djearaman
(M)
Salma Kadiri
(S)
Aiman Alzetani
(A)
Jennifer Richards
(J)
Lydia Scarlett
(L)
Papawadee Ingram
(P)
Serena Chee
(S)
Silvia Austin
(S)
Amrita Bajaj
(A)
Apostolos Nakas
(A)
Azmina Sodha-Ramdeen
(A)
Dean A Fennell
(DA)
Keng Ang
(K)
Mohamad Tufail
(M)
Mohammed Fiyaz Chowdhry
(MF)
Molly Scotland
(M)
Rebecca Boyles
(R)
Sridhar Rathinam
(S)
Claire Wilson
(C)
Domenic Marrone
(D)
Sean Dulloo
(S)
Angeles Montero
(A)
Elaine Smith
(E)
Eustace Fontaine
(E)
Felice Granato
(F)
Helen Doran
(H)
Juliette Novasio
(J)
Kendadai Rammohan
(K)
Leena Joseph
(L)
Paul Bishop
(P)
Rajesh Shah
(R)
Stuart Moss
(S)
Vijay Joshi
(V)
Hugo J W L Aerts
(HJWL)
Tom L Kaufmann
(TL)
Roland F Schwarz
(RF)
Judit Kisistok
(J)
Mateo Sokac
(M)
Miklos Diossy
(M)
Zoltan Szallasi
(Z)
Krijn Dijkstra
(K)
Yinyin Yuan
(Y)
Fiona Byrne
(F)
Laura Amanda Boos
(LA)
Benjamin Shum
(B)
Camille L Gerard
(CL)
Andreas M Schmitt
(AM)
Christina Messiou
(C)
David Cunningham
(D)
Ian Chau
(I)
Naureen Starling
(N)
Nicholas Turner
(N)
Liam Welsh
(L)
Robin L Jones
(RL)
Joanne Droney
(J)
Susana Banerjee
(S)
Kate C Tatham
(KC)
Shaman Jhanji
(S)
Kevin Harrington
(K)
Alicia Okines
(A)
Alison Reid
(A)
Kate Young
(K)
Andrew J S Furness
(AJS)
Lisa Pickering
(L)
Emma Nicholson
(E)
Sacheen Kumar
(S)
Katalin A Wilkinson
(KA)
Anthony Swerdlow
(A)
Robert J Wilkinson
(RJ)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s).
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