The Association of Circulating L-Carnitine, γ-Butyrobetaine and Trimethylamine N-Oxide Levels with Gastric Cancer.
L-carnitine
biomarker
diagnostic
gastric cancer
metabolite
trimethylamine N-oxide
γ-butyrobetaine
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
04 Apr 2023
04 Apr 2023
Historique:
received:
14
03
2023
revised:
28
03
2023
accepted:
31
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Our study aimed to evaluate the association between gastric cancer (GC) and higher concentrations of the metabolites L-carnitine, γ-butyrobetaine (GBB) and gut microbiota-mediated trimethylamine N-oxide (TMAO) in the circulation. There is evidence suggesting that higher levels of TMAO and its precursors in blood can be indicative of either a higher risk of malignancy or indeed its presence; however, GC has not been studied in this regard until now. Our study included 83 controls without high-risk stomach lesions and 105 GC cases. Blood serum L-carnitine, GBB and TMAO levels were measured by ultra-high-performance liquid chromatography-mass spectrometry (UPLC/MS/MS). Although there were no significant differences between female control and GC groups, we found a significant difference in circulating levels of metabolites between the male control group and the male GC group, with median levels of L-carnitine reaching 30.22 (25.78-37.57) nmol/mL vs. 37.38 (32.73-42.61) nmol/mL (
Identifiants
pubmed: 37046558
pii: diagnostics13071341
doi: 10.3390/diagnostics13071341
pmc: PMC10093028
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : State Research programme project in biomedical, medical technologies and pharmaceuti-cals
ID : VPP-EM-BIOMEDICĪNA-2022/1-0001
Références
Sci Rep. 2019 Aug 26;9(1):12370
pubmed: 31451722
PLoS One. 2013 Aug 14;8(8):e70955
pubmed: 23967140
Cancer Res. 2014 Dec 15;74(24):7442-52
pubmed: 25336191
Front Pharmacol. 2021 Oct 26;12:760581
pubmed: 34764874
Curr Pharm Des. 2017;23(25):3699-3712
pubmed: 28641532
Med Hypotheses. 2017 Jan;98:35-37
pubmed: 28012600
Nutr Cancer. 2023;75(2):402-414
pubmed: 36217110
Front Oncol. 2022 Jul 07;12:891619
pubmed: 35875107
EClinicalMedicine. 2022 Apr 21;47:101404
pubmed: 35497064
J Gastrointest Cancer. 2013 Sep;44(3):362-5
pubmed: 23609166
J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):287-295
pubmed: 34939358
PLoS One. 2016 May 26;11(5):e0154090
pubmed: 27228093
BMJ Open. 2017 Aug 11;7(8):e016999
pubmed: 28801429
Front Immunol. 2022 Dec 22;13:955476
pubmed: 36618350
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 27377678
Gut Microbes. 2021 Jan-Dec;13(1):1-22
pubmed: 33938378
Nutr Metab (Lond). 2018 Nov 20;15:81
pubmed: 30479648
J Clin Invest. 2019 Jan 2;129(1):373-387
pubmed: 30530985
Nutrition. 2019 Oct;66:29-37
pubmed: 31202134
JAMA. 2019 Jun 11;321(22):2149-2151
pubmed: 31116376
Hum Mol Genet. 1998 May;7(5):839-45
pubmed: 9536088
Cell Death Dis. 2018 Feb 14;9(2):228
pubmed: 29445084
Clin Chim Acta. 1976 Mar 1;67(2):207-12
pubmed: 1248154
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Aliment Pharmacol Ther. 2020 Mar;51(6):582-602
pubmed: 32056247
J Clin Pharmacol. 2013 Oct;53(10):1095-8
pubmed: 23893520
Biomark Med. 2017 May;11(5):443-447
pubmed: 28621609
Mediators Inflamm. 2020 Feb 17;2020:4634172
pubmed: 32148438
J Pharm Pharmacol. 2011 Sep;63(9):1195-201
pubmed: 21827492
J Clin Med. 2022 Mar 04;11(5):
pubmed: 35268516
J Gastrointest Oncol. 2020 Aug;11(4):695-707
pubmed: 32953153
Br Med J. 1904 Nov 26;2(2291):1457-60
pubmed: 20761788
J Ren Nutr. 2015 Jul;25(4):351-6
pubmed: 25802017
Int J Cancer. 2020 Oct 1;147(7):1917-1927
pubmed: 32222976
Helicobacter. 2018 Aug;23(4):e12498
pubmed: 29897654
Biomed Chromatogr. 2015 Nov;29(11):1670-4
pubmed: 25873316
Int J Mol Sci. 2020 Aug 26;21(17):
pubmed: 32859047
Cell Metab. 2014 Nov 4;20(5):799-812
pubmed: 25440057
Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):945-952
pubmed: 28077427
Gastroenterology. 2021 Jun;160(7):2395-2408
pubmed: 33581124
Prz Gastroenterol. 2019;14(1):26-38
pubmed: 30944675
Nutrients. 2022 Nov 24;14(23):
pubmed: 36501029
BMC Genomics. 2015;16 Suppl 7:S4
pubmed: 26100814
J Cancer. 2019 Oct 8;10(23):5874-5882
pubmed: 31737123
Int J Mol Sci. 2018 Oct 19;19(10):
pubmed: 30347638
J Am Heart Assoc. 2017 Jun 29;6(7):
pubmed: 28663251
Front Cell Dev Biol. 2020 Sep 18;8:583850
pubmed: 33072764
Ann Nutr Metab. 2017;71(3-4):261-265
pubmed: 29237151
Sci Immunol. 2022 Sep 9;7(75):eabn0704
pubmed: 36083892
Nutrients. 2020 May 07;12(5):
pubmed: 32392758
Gut. 2007 May;56(5):631-6
pubmed: 17142647
Am J Clin Nutr. 2014 Sep;100(3):778-86
pubmed: 24944063
Eur J Epidemiol. 2021 Sep;36(9):937-951
pubmed: 34455534
Front Cardiovasc Med. 2021 Nov 23;8:723886
pubmed: 34888358
Gut. 2019 Aug;68(8):1439-1449
pubmed: 30377191